CDK5RAP3 - CDK5 regulatory subunit associated protein 3 Gene

中文名称：CDK5 调节亚基相关蛋白 3

种属: Homo sapiens

同用名: C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114

基因 ID: 80279 | 基因类型: protein coding

关于 CDK5RAP3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,967,904-47,981,781 (from NCBI)

This gene has 37 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in spleen (RPKM 44.2), lymph node (RPKM 40.3) and 25 other tissues.

功能概要

该基因编码一种蛋白质，据报道该蛋白质在控制转录调节和细胞周期进程的信号通路中发挥作用。它可能在肿瘤发生和转移中发挥作用。该基因的一个假基因位于 20 号染色体的长臂上。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 5 月]

This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

CDK5RAP3 基因产物(5)

mRNA	Protein	Name
NM_001278197.2	NP_001265126.1	CDK5 regulatory subunit-associated protein 3 isoform c
NM_001278198.2	NP_001265127.1	CDK5 regulatory subunit-associated protein 3 isoform d
NM_001278216.2	NP_001265145.1	CDK5 regulatory subunit-associated protein 3 isoform e
NM_001278217.2	NP_001265146.1	CDK5 regulatory subunit-associated protein 3 isoform f
NM_176096.3	NP_788276.1	CDK5 regulatory subunit-associated protein 3 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MDM2/MDM4 family protein binding	IPI IPI: 通过物理相互作用推断	16173922	GOA
enables NF-kappaB binding	IPI IPI: 通过物理相互作用推断	17785205	GOA
enables cyclin binding	IPI IPI: 通过物理相互作用推断	15790566	GOA
enables mitogen-activated protein kinase binding	IPI IPI: 通过物理相互作用推断	21283629	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16173922	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	19223857	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	36121123	GOA
enables ubiquitin-like protein ligase binding	IDA IDA: 通过直接分析推断	20531390	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apoptotic nuclear changes	IMP IMP: 通过突变表型推断	23478299	GOA
involved in cell population proliferation	IDA IDA: 通过直接分析推断	12054757	GOA
involved in endoplasmic reticulum unfolded protein response	IMP IMP: 通过突变表型推断	23152784	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	15790566	GOA
involved in mitotic G2/M transition checkpoint	IMP IMP: 通过突变表型推断	19223857	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: 通过突变表型推断	21283629	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	17785205	GOA
involved in negative regulation of protein catabolic process	IDA IDA: 通过直接分析推断	16173922	GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	21283629	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	17785205	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	19223857	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: 通过直接分析推断	16173922	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	16173922	GOA
involved in positive regulation of reticulophagy	IDA IDA: 通过直接分析推断	36543799	GOA
involved in positive regulation of reticulophagy	IMP IMP: 通过突变表型推断	32851973	GOA
involved in positive regulation of signal transduction by p53 class mediator	IDA IDA: 通过直接分析推断	16173922	GOA
NOT involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	16173922	GOA
acts upstream of or within protein ufmylation	IDA IDA: 通过直接分析推断	23152784	GOA
involved in protein ufmylation	IDA IDA: 通过直接分析推断	36121123	GOA
involved in protein ufmylation	IMP IMP: 通过突变表型推断	30635284	GOA
involved in regulation of phosphatase activity	IMP IMP: 通过突变表型推断	21283629	GOA
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	37595036	GOA
involved in rescue of stalled ribosome	IMP IMP: 通过突变表型推断	32851973	GOA
involved in ribosome disassembly	IDA IDA: 通过直接分析推断	38383785	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	19223857	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15790566	GOA
is active in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	36543799	GOA
colocalizes with microtubule	IDA IDA: 通过直接分析推断	23478299	GOA
NOT located in nucleolus	IDA IDA: 通过直接分析推断	16173922	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16173922	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	20531390	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK5RAP3 蛋白结构

DUF773

0
100
200
300
400
506 a.a.

蛋白主名

其他名称

CDK5 regulatory subunit-associated protein 3

CDK5 regulatory subunit associated protein IC53-2

CDK5RAP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CDK5RAP3	Q96JB5	UFC1	Homo sapiens	Q9Y3C8	Anti Bait CoIP	17353931
Intra	CDK5RAP3	Q96JB5	UFC1	Homo sapiens	Q9Y3C8	Pull Down	37595036
Intra	CDK5RAP3	Q96JB5	UFC1	Homo sapiens	Q9Y3C8	Anti Tag CoIP	37595036
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Anti Tag CoIP	37595036
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Pull Down	37595036
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Anti Tag CoIP	33961781
Intra	CDK5RAP3	Q96JB5	UFL1	Homo sapiens	O94874	Anti Bait CoIP	17353931
Intra	CDK5RAP3	Q96JB5	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	32296183
Intra	CDK5RAP3	Q96JB5	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	25416956
Intra	CDK5RAP3	Q96JB5	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17785205
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	Y2H Array	31515488
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	Y2H Prey Pooling	25416956
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	Y2H Array	25416956
Intra	CDK5RAP3	Q96JB5	FKBP6	Homo sapiens	O75344	MAPPIT	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type	Beukes Familial Hip Dysplasia
BFHD	Cilliers-Beighton Syndrome
Osteoarthropathy, Premature Degenerative, Of Hip	Premature Degenerative Osteoarthropathy Of The Hip
BHD	Beukes Type Hip Dysplasia
Hip Dysplasia Beukes Type	Premature Degenerative Osteoarthropathy
Dysplasia, Hip, Beukes Type

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02391	CDK5RAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CDK5RAP3	RGD	RGD:620002
Bos taurus	CDK5RAP3	VGNC	VGNC:27132
Macaca mulatta	CDK5RAP3	VGNC	VGNC:71015
Felis catus	CDK5RAP3	VGNC	VGNC:60704
Canis familiaris	CDK5RAP3	VGNC	VGNC:39059
Mus musculus	CDK5RAP3	MGD	MGI:1933126

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