2. Gene
  3. FKBP6 - FKBP prolyl isomerase family member 6 (inactive) Gene

FKBP6 - FKBP prolyl isomerase family member 6 (inactive) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：FKBP 脯氨酰异构酶家族成员 6 (无活性)

种属: Homo sapiens

同用名: FKBP36; SPGF77

基因 ID: 8468 | 基因类型: protein coding

关于 FKBP6

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,328,161-73,358,625 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 18 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 29.4).

功能概要

该基因编码的蛋白质是一种顺反式肽基-脯氨酰异构酶，可能在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。该基因位于 Williams-Beuren 综合征中缺失的染色体区域。该基因的缺陷可能导致男性不育。该基因有多个假基因位于 7 号染色体附近。可变剪接导致多个转录本变异。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

FKBP6 基因产物(4)

mRNA Protein Name
NM_001135211.3 NP_001128683.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform b
NM_001281304.2 NP_001268233.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform c
NM_001362789.2 NP_001349718.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform d
NM_003602.5 NP_003593.3 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
26567527 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of viral genome replication IMP
IMP: 通过突变表型推断
26567527 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FKBP6 蛋白结构

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (53 - 140)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
蛋白主名 其他名称

inactive peptidyl-prolyl cis-trans isomerase FKBP6

36 kDa FKBP

FKBP6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra FKBP6 O75344 SUMO1P1 Homo sapiens G2XKQ0
Validated Y2H
25910212
Intra FKBP6 O75344 SUMO1P1 Homo sapiens G2XKQ0
Y2H Array
25910212
Intra FKBP6 O75344 SUMO1P1 Homo sapiens G2XKQ0
Validated Y2H
25416956
Intra FKBP6 O75344 SUMO1P1 Homo sapiens G2XKQ0
Y2H Bait-Prey Pool
25910212
Intra FKBP6 O75344 RAB11FIP2 Homo sapiens Q7L804
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 RAB11FIP2 Homo sapiens Q7L804
Validated Y2H
32296183
Intra FKBP6 O75344 RAB11FIP2 Homo sapiens Q7L804
Y2H Array
32296183
Intra FKBP6 O75344 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra FKBP6 O75344 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra FKBP6 O75344 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra FKBP6 O75344 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Array
32296183
Intra FKBP6 O75344 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra FKBP6 O75344 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Array
32296183
Intra FKBP6 O75344 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra FKBP6 O75344 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra FKBP6 O75344 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra FKBP6 O75344 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra FKBP6 O75344 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra FKBP6 O75344 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra FKBP6 O75344 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra FKBP6 O75344 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra FKBP6 O75344 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 RNF4 Homo sapiens P78317
Validated Y2H
32296183
Intra FKBP6 O75344 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra FKBP6 O75344 OSBP Homo sapiens P22059
Anti Tag CoIP
33961781
Intra FKBP6 O75344 OSBP Homo sapiens P22059
Anti Tag CoIP
28514442
Intra FKBP6 O75344 OSBP Homo sapiens P22059
Anti Tag CoIP
25036637
Intra FKBP6 O75344 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra FKBP6 O75344 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra FKBP6 O75344 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra FKBP6 O75344 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 PIAS2 Homo sapiens O75928-2
Validated Y2H
32296183
Intra FKBP6 O75344 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra FKBP6 O75344 GAPDH Homo sapiens P04406
Y2H Pooling
32814053
Intra FKBP6 O75344 GAPDH Homo sapiens P04406
Validated Y2H
32814053
Intra FKBP6 O75344 GAPDH Homo sapiens P04406
Y2H Array
32814053
Intra FKBP6 O75344 STUB1 Homo sapiens Q9UNE7
Validated Y2H
32814053
Intra FKBP6 O75344 STUB1 Homo sapiens Q9UNE7
Y2H Array
32814053
Intra FKBP6 O75344 STUB1 Homo sapiens Q9UNE7
Y2H Pooling
32814053
Intra FKBP6 O75344 ALDH3A1 Homo sapiens P30838
Validated Y2H
32296183
Intra FKBP6 O75344 ALDH3A1 Homo sapiens P30838
Y2H Array
32296183
Intra FKBP6 O75344 ALDH3A1 Homo sapiens P30838
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 EEF1D Homo sapiens P29692-2
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 EEF1D Homo sapiens P29692-2
Validated Y2H
32296183
Intra FKBP6 O75344 EEF1D Homo sapiens P29692-2
Y2H Array
32296183
Intra FKBP6 O75344 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra FKBP6 O75344 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra FKBP6 O75344 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Y2H Array
32296183
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Validated Y2H
32296183
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Validated Y2H
25910212
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Y2H Array
31515488
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Y2H Bait-Prey Pool
25910212
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Y2H Array
25910212
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Validated Y2H
25416956
Intra FKBP6 O75344 CDK5RAP3 Homo sapiens Q96JB5
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 TMEM9B Homo sapiens Q9NQ34
Validated Y2H
32296183
Intra FKBP6 O75344 FKBP8 Homo sapiens Q14318
Anti Tag CoIP
26567527
Intra FKBP6 O75344 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra FKBP6 O75344 CBS Homo sapiens P35520
Validated Y2H
32814053
Intra FKBP6 O75344 CBS Homo sapiens P35520
Y2H Pooling
32814053
Intra FKBP6 O75344 CBS Homo sapiens P35520
Y2H Array
32814053
Intra FKBP6 O75344 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25910212
Intra FKBP6 O75344 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25910212
Intra FKBP6 O75344 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra FKBP6 O75344 LZTS2 Homo sapiens Q9BRK4
Y2H Bait-Prey Pool
25910212
Intra FKBP6 O75344 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra FKBP6 O75344 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra FKBP6 O75344 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra FKBP6 O75344 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra FKBP6 O75344 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25910212
Intra FKBP6 O75344 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra FKBP6 O75344 IHO1 Homo sapiens Q8IYA8
Y2H Bait-Prey Pool
25910212
Intra FKBP6 O75344 IHO1 Homo sapiens Q8IYA8
Y2H Array
25910212
Intra FKBP6 O75344 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra FKBP6 O75344 NME7 Homo sapiens Q9Y5B8
Y2H Pooling
16189514
Intra FKBP6 O75344 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra FKBP6 O75344 MEOX2 Homo sapiens P50222
Y2H Bait-Prey Pool
25910212
Intra FKBP6 O75344 MEOX2 Homo sapiens P50222
Validated Y2H
25910212
Intra FKBP6 O75344 MEOX2 Homo sapiens P50222
Y2H Array
25910212
Intra FKBP6 O75344 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra FKBP6 O75344 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra FKBP6 O75344 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 CFP Homo sapiens P27918
Y2H Array
32296183
Intra FKBP6 O75344 CFP Homo sapiens P27918
Y2H Prey Pooling
32296183
Intra FKBP6 O75344 CFP Homo sapiens P27918
Validated Y2H
32296183
Cross FKBP6 O75344 Usp19 Mus musculus Q3UJD6-2
Lumier
25036637
Intra FKBP6 O75344 ECM1 Homo sapiens Q16610
Validated Y2H
32296183
Intra FKBP6 O75344 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra FKBP6 O75344 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2

Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss

EDSKSCL2

Edskmh

Ehlers-Danlos Syndrome Kyphoscoliotic Type 2

Kyphoscoliotic Ehlers-Danlos Syndrome Due To Fkbp22 Deficiency

Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Deafness

Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Hearing Loss

Fkbp14-Related Eds

Fkbp22-Deficient Eds

Kyphoscoliotic Eds Due To Fkbp22 Deficiency

Keds-Fkbp14

Ehlers-Danlos Syndrome, With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss

Ehlers-Danlos Syndrome, Kyphoscoliotic, Type 2
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Supravalvular Aortic Stenosis

SVAS

Supravalvar Aortic Stenosis

Supravalvar Aortic Stenosis, Eisenberg Type

Aortic Supravalvular Stenosis

Aortic Stenosis, Supravalvular

Supra-Valvular Aortic Stenosis

Stenosis, Aortic Supravalvular

Stenosis, Supravalvular Aortic

Supravalvular Stenosis, Aortic

Aortic Stenosis Supravalvular
Williams-Beuren Region Duplication Syndrome

7q11.23 Duplication Syndrome

7q11.23 Microduplication Syndrome

Chromosome 7q11.23 Duplication Syndrome

Wbs Duplication Syndrome

Somerville-Van Der Aa Syndrome

Dup(7)(Q11.23)

Trisomy 7q11.23

William-Beuren Region Duplication Syndrome

Chromosome 7q11.23 Duplication
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome

Del(17)(Q12)

Monosomy 17q12
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04966 FKBP6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FKBP6 RGD RGD:1308926
Macaca mulatta FKBP6 VGNC VGNC:72666
Mus musculus FKBP6 MGD MGI:2137612
Felis catus FKBP6 VGNC VGNC:62282
Bos taurus FKBP6 VGNC VGNC:29025
Canis familiaris FKBP6 VGNC VGNC:40892
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