2. Gene
  3. CRACR2A - calcium release activated channel regulator 2A Gene

CRACR2A - calcium release activated channel regulator 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙释放激活通道调节因子 2A

种属: Homo sapiens

同用名: RAB46; EFCAB4B

基因 ID: 84766 | 基因类型: protein coding

关于 CRACR2A

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,615,328-3,753,109 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 1 paralogue. Broad expression in salivary gland (RPKM 9.7), colon (RPKM 7.2) and 16 other tissues.

功能概要

启用 GTPase 活性和钙离子结合活性。涉及多个过程，包括激活钙通道活动； JNK 级联的正调控；和商店经营的钙入口。位于多种细胞成分中，包括高尔基体； Weibel-Palade 体；和免疫突触。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated Calcium Channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

CRACR2A 基因产物(2)

mRNA Protein Name
NM_001144958.2 NP_001138430.1 EF-hand calcium-binding domain-containing protein 4B isoform a
NM_032680.4 NP_116069.1 EF-hand calcium-binding domain-containing protein 4B isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IMP
IMP: 通过突变表型推断
27016526 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
20418871 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20418871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper 1 cell differentiation IMP
IMP: 通过突变表型推断
29987160 GOA
involved in activation of store-operated calcium channel activity IMP
IMP: 通过突变表型推断
20418871 GOA
involved in endosomal transport IDA
IDA: 通过直接分析推断
30814157 GOA
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
27016526 GOA
involved in positive regulation of calcium ion transport IMP
IMP: 通过突变表型推断
20418871 GOA
involved in protein localization IMP
IMP: 通过突变表型推断
20418871 GOA
involved in response to histamine IDA
IDA: 通过直接分析推断
31092558 GOA
involved in store-operated calcium entry IMP
IMP: 通过突变表型推断
20418871 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
27016526 GOA
located in Weibel-Palade body IDA
IDA: 通过直接分析推断
31092558 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
20418871 GOA
located in immunological synapse IDA
IDA: 通过直接分析推断
27016526 GOA
located in microtubule organizing center IDA
IDA: 通过直接分析推断
30814157 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
30814157 GOA
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
27016526 GOA
located in vesicle IDA
IDA: 通过直接分析推断
27016526 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRACR2A 蛋白结构

EF-hand_8

EF-hand_8: EF-hand domain pair (67 - 113)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
蛋白主名 其他名称

EF-hand calcium-binding domain-containing protein 4B

CRAC channel regulator 2A

CRACR2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CRACR2A Q9BSW2 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 PNMA5 Homo sapiens Q96PV4
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
种属内
CRACR2A Q9BSW2 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 SLAIN1 Homo sapiens Q8ND83
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 SLAIN1 Homo sapiens Q8ND83
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
种属内
CRACR2A Q9BSW2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
种属内
CRACR2A Q9BSW2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
种属内
CRACR2A Q9BSW2 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 RBAK Homo sapiens Q9NYW8
Validated Y2H
32296183
种属内
CRACR2A Q9BSW2 RBAK Homo sapiens Q9NYW8
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 RBAK Homo sapiens Q9NYW8
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
种属内
CRACR2A Q9BSW2 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 ASB3 Homo sapiens Q9Y575-3
Validated Y2H
32296183
种属内
CRACR2A Q9BSW2 ASB3 Homo sapiens Q9Y575-3
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 ASB3 Homo sapiens Q9Y575-3
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 MCPH1 Homo sapiens Q8NEM0
Anti Tag CoIP
28514442
种属内
CRACR2A Q9BSW2 MCPH1 Homo sapiens Q8NEM0
Anti Tag CoIP
33961781
种属内
CRACR2A Q9BSW2 ANKRD29 Homo sapiens Q8N6D5
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 ANKRD29 Homo sapiens Q8N6D5
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 RORB Homo sapiens Q92753-1
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 RORB Homo sapiens Q92753-1
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 ORAI1 Homo sapiens Q96D31
Pull Down
20418871
种属内
CRACR2A Q9BSW2 ORAI1 Homo sapiens Q96D31
Anti Tag CoIP
20418871
种属内
CRACR2A Q9BSW2 MKRN3 Homo sapiens Q13064
Validated Y2H
25416956
种属内
CRACR2A Q9BSW2 KRT75 Homo sapiens O95678
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
种属间
CRACR2A Q9BSW2 Hoxa1 Mus musculus P09022
Y2H
23088713
种属间
CRACR2A Q9BSW2 Hoxa1 Mus musculus P09022
BiFC
23088713
种属间
CRACR2A Q9BSW2 Hoxa1 Mus musculus P09022
Pull Down
23088713
种属内
CRACR2A Q9BSW2 STIM1 Homo sapiens Q13586
Anti Tag CoIP
20418871
种属内
CRACR2A Q9BSW2 STIM1 Homo sapiens Q13586
Pull Down
20418871
种属内
CRACR2A Q9BSW2 STIM1 Homo sapiens Q13586
IF
20418871
种属内
CRACR2A Q9BSW2 LRIF1 Homo sapiens Q5T3J3
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 LRIF1 Homo sapiens Q5T3J3
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
CRACR2A Q9BSW2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
CRACR2A Q9BSW2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
CRACR2A Q9BSW2 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 OIP5 Homo sapiens O43482
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 ZNF20 Homo sapiens P17024
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 ZNF20 Homo sapiens P17024
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
种属内
CRACR2A Q9BSW2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 SORBS3 Homo sapiens O60504
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 DDIT3 Homo sapiens P35638
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 FKBP6 Homo sapiens O75344
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 FKBP6 Homo sapiens O75344
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 FAM156B Homo sapiens Q8NDB6
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 FAM156B Homo sapiens Q8NDB6
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
种属内
CRACR2A Q9BSW2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
种属内
CRACR2A Q9BSW2 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
种属内
CRACR2A Q9BSW2 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属内
CRACR2A Q9BSW2 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma
Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis

Stormorken-Sjaastad-Langslet Syndrome

STRMK

York Platelet Syndrome

Yps

Thrombocytopathy, Asplenia And Miosis

Thrombocytopathy Asplenia Miosis

Thrombocytopathy-Asplenia-Miosis Syndrome

Miosis Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03137 CRACR2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CRACR2A RGD RGD:1563719
Felis catus CRACR2A VGNC VGNC:61157
Mus musculus CRACR2A MGD MGI:2685919
Canis familiaris CRACR2A VGNC VGNC:39589
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