CRACR2A - calcium release activated channel regulator 2A Gene

中文名称：钙释放激活通道调节因子 2A

种属: Homo sapiens

同用名: RAB46; EFCAB4B

基因 ID: 84766 | 基因类型: protein coding

关于 CRACR2A

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,615,328-3,753,109 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 1 paralogue. Broad expression in salivary gland (RPKM 9.7), colon (RPKM 7.2) and 16 other tissues.

功能概要

启用 GTPase 活性和钙离子结合活性。涉及多个过程，包括激活钙通道活动； JNK 级联的正调控；和商店经营的钙入口。位于多种细胞成分中，包括高尔基体； Weibel-Palade 体；和免疫突触。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated Calcium Channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

CRACR2A 基因产物(2)

mRNA	Protein	Name
NM_001144958.2	NP_001138430.1	EF-hand calcium-binding domain-containing protein 4B isoform a
NM_032680.4	NP_116069.1	EF-hand calcium-binding domain-containing protein 4B isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activity	IMP IMP: 通过突变表型推断	27016526	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	20418871	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20418871	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in T-helper 1 cell differentiation	IMP IMP: 通过突变表型推断	29987160	GOA
involved in activation of store-operated calcium channel activity	IMP IMP: 通过突变表型推断	20418871	GOA
involved in endosomal transport	IDA IDA: 通过直接分析推断	30814157	GOA
involved in positive regulation of JNK cascade	IMP IMP: 通过突变表型推断	27016526	GOA
involved in positive regulation of calcium ion transport	IMP IMP: 通过突变表型推断	20418871	GOA
involved in protein localization	IMP IMP: 通过突变表型推断	20418871	GOA
involved in response to histamine	IDA IDA: 通过直接分析推断	31092558	GOA
involved in store-operated calcium entry	IMP IMP: 通过突变表型推断	20418871	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	27016526	GOA
located in Weibel-Palade body	IDA IDA: 通过直接分析推断	31092558	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	20418871	GOA
located in immunological synapse	IDA IDA: 通过直接分析推断	27016526	GOA
located in microtubule organizing center	IDA IDA: 通过直接分析推断	30814157	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	30814157	GOA
located in trans-Golgi network membrane	IDA IDA: 通过直接分析推断	27016526	GOA
located in vesicle	IDA IDA: 通过直接分析推断	27016526	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRACR2A 蛋白结构

EF-hand_8

0
100
200
300
395 a.a.

蛋白主名

其他名称

EF-hand calcium-binding domain-containing protein 4B

CRAC channel regulator 2A

CRACR2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CRACR2A	Q9BSW2	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	PNMA5	Homo sapiens	Q96PV4	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	CRACR2A	Q9BSW2	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	SLAIN1	Homo sapiens	Q8ND83	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	SLAIN1	Homo sapiens	Q8ND83	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	CRACR2A	Q9BSW2	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	CRACR2A	Q9BSW2	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	CRACR2A	Q9BSW2	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	RBAK	Homo sapiens	Q9NYW8	Validated Y2H	32296183
种属内	CRACR2A	Q9BSW2	RBAK	Homo sapiens	Q9NYW8	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	RBAK	Homo sapiens	Q9NYW8	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
种属内	CRACR2A	Q9BSW2	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	ASB3	Homo sapiens	Q9Y575-3	Validated Y2H	32296183
种属内	CRACR2A	Q9BSW2	ASB3	Homo sapiens	Q9Y575-3	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	ASB3	Homo sapiens	Q9Y575-3	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	MCPH1	Homo sapiens	Q8NEM0	Anti Tag CoIP	28514442
种属内	CRACR2A	Q9BSW2	MCPH1	Homo sapiens	Q8NEM0	Anti Tag CoIP	33961781
种属内	CRACR2A	Q9BSW2	ANKRD29	Homo sapiens	Q8N6D5	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	ANKRD29	Homo sapiens	Q8N6D5	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	RORB	Homo sapiens	Q92753-1	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	RORB	Homo sapiens	Q92753-1	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	ORAI1	Homo sapiens	Q96D31	Pull Down	20418871
种属内	CRACR2A	Q9BSW2	ORAI1	Homo sapiens	Q96D31	Anti Tag CoIP	20418871
种属内	CRACR2A	Q9BSW2	MKRN3	Homo sapiens	Q13064	Validated Y2H	25416956
种属内	CRACR2A	Q9BSW2	KRT75	Homo sapiens	O95678	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
种属间	CRACR2A	Q9BSW2	Hoxa1	Mus musculus	P09022	Y2H	23088713
种属间	CRACR2A	Q9BSW2	Hoxa1	Mus musculus	P09022	BiFC	23088713
种属间	CRACR2A	Q9BSW2	Hoxa1	Mus musculus	P09022	Pull Down	23088713
种属内	CRACR2A	Q9BSW2	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	20418871
种属内	CRACR2A	Q9BSW2	STIM1	Homo sapiens	Q13586	Pull Down	20418871
种属内	CRACR2A	Q9BSW2	STIM1	Homo sapiens	Q13586	IF	20418871
种属内	CRACR2A	Q9BSW2	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	CRACR2A	Q9BSW2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	CRACR2A	Q9BSW2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	CRACR2A	Q9BSW2	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	OIP5	Homo sapiens	O43482	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	ZNF20	Homo sapiens	P17024	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	ZNF20	Homo sapiens	P17024	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
种属内	CRACR2A	Q9BSW2	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	DDIT3	Homo sapiens	P35638	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	DDIT3	Homo sapiens	P35638	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	FKBP6	Homo sapiens	O75344	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	FKBP6	Homo sapiens	O75344	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	FAM156B	Homo sapiens	Q8NDB6	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	FAM156B	Homo sapiens	Q8NDB6	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
种属内	CRACR2A	Q9BSW2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
种属内	CRACR2A	Q9BSW2	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
种属内	CRACR2A	Q9BSW2	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	CRACR2A	Q9BSW2	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03137	CRACR2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CRACR2A	RGD	RGD:1563719
Felis catus	CRACR2A	VGNC	VGNC:61157
Mus musculus	CRACR2A	MGD	MGI:2685919
Canis familiaris	CRACR2A	VGNC	VGNC:39589

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