RBAK - RB associated KRAB zinc finger Gene

中文名称：RB 相关的 KRAB 锌指

种属: Homo sapiens

同用名: ZNF769

关于 RBAK

功能概要

该基因编码一种与肿瘤抑制因子视网膜母细胞瘤 1 相互作用的核蛋白。这两种相互作用的蛋白质被认为充当由 E2F1 转录因子激活的启动子的转录抑制因子。这种蛋白质包含一个 Kruppel 相关框 (KRAB) ，它是一种转录抑制基序。包含来自下游基因 LOC389458 的外显子的通读转录本从该基因座表达。[RefSeq 提供，2011 年 3 月]

This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]