ORAI1 - ORAI calcium release-activated calcium modulator 1 Gene

中文名称：ORAI 钙释放激活钙调节因子 1

种属: Homo sapiens

同用名: IMD9; TAM2; ORAT1; CRACM1; TMEM142A

基因 ID: 84876 | 基因类型: protein coding

关于 ORAI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,626,550-121,642,040 (from NCBI)

功能概要

由该基因编码的蛋白质是一种膜钙通道亚基，当钙储备耗尽时，它会被钙传感器 STIM1 激活。这种类型的通道是钙流入 T 细胞的主要途径。该基因的缺陷是由于 1 型钙进入缺陷 (IDTICED1) 导致的 T 细胞失活导致免疫功能障碍的原因。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene is a membrane Calcium Channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

ORAI1 基因产物(1)

mRNA	Protein	Name
NM_032790.3	NP_116179.2	calcium release-activated calcium channel protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium channel activity	IDA IDA: 通过直接分析推断	31009446	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18757751	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17360584	GOA
enables store-operated calcium channel activity	IDA IDA: 通过直接分析推断	16645049	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcineurin-NFAT signaling cascade	IMP IMP: 通过突变表型推断	33941685	GOA
involved in calcium ion transmembrane transport	IDA IDA: 通过直接分析推断	31009446	GOA
involved in positive regulation of adenylate cyclase activity	IDA IDA: 通过直接分析推断	19171672	GOA
involved in positive regulation of calcium ion transport	IDA IDA: 通过直接分析推断	16645049	GOA
involved in regulation of calcium ion transport	IMP IMP: 通过突变表型推断	16921383	GOA
involved in store-operated calcium entry	IDA IDA: 通过直接分析推断	16921383	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane raft	IDA IDA: 通过直接分析推断	22494970	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16645049	GOA
located in plasma membrane raft	IDA IDA: 通过直接分析推断	19171672	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ORAI1 蛋白结构

Orai-1

0
100
200
303 a.a.

蛋白主名

其他名称

calcium release-activated calcium channel protein 1

calcium release-activated calcium modulator 1

ORAI1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Cross	ORAI1	Q96D31	Trpc6	Mus musculus	Q61143	Anti Tag CoIP	17360584
Cross	ORAI1	Q96D31	Trpc6	Mus musculus	Q61143	Pull Down	17360584
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Pull Down	19249086
Intra	ORAI1	Q96D31	ORAI1	Homo sapiens	Q96D31	Crosslink	20018736
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Ub Reconstruction	19249086
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	19249086
Intra	ORAI1	Q96D31	ORAI1	Homo sapiens	Q96D31	GMS	19249086
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	19706554
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	AFM	24996186
Intra	ORAI1	Q96D31	ORAI1	Homo sapiens	Q96D31	FRET	18757751
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	GMS	19249086
Intra	ORAI1	Q96D31	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	20418871
Intra	ORAI1	Q96D31	EFHB	Homo sapiens	Q8N7U6	Anti Bait CoIP	30481768
Intra	ORAI1	Q96D31	ATP2C2	Homo sapiens	O75185	Confocal	20887894
Intra	ORAI1	Q96D31	ATP2C2	Homo sapiens	O75185	Anti Bait CoIP	20887894
Intra	ORAI1	Q96D31	ATP2C2	Homo sapiens	O75185	Pull Down	20887894
Intra	ORAI1	Q96D31	ORAI3	Homo sapiens	Q9BRQ5	Confocal	24954132
Intra	ORAI1	Q96D31	ORAI3	Homo sapiens	Q9BRQ5	FRET	19887627
Intra	ORAI1	Q96D31	CRACR2A	Homo sapiens	Q9BSW2	Anti Tag CoIP	20418871
Intra	ORAI1	Q96D31	CRACR2A	Homo sapiens	Q9BSW2	Pull Down	20418871
Intra	ORAI1	Q96D31	TRPC1	Homo sapiens	P48995	Anti Bait CoIP	21408196

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 9

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1	Combined Immunodeficiency Due To Orai1 Deficiency
IMD9	Cid Due To Orai1 Deficiency
Severe Combined Immunodeficiency Due To Crac Channel Dysfunction	Immunodeficiency, Type 9

Myopathy, Tubular Aggregate, 2

TAM2	Tubular Aggregate Myopathy 2

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Anhidrosis

Hypohidrosis	Absence Of Sweating
Adiaphoresis	Impaired Sweating
Oligohidrosis

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Urolithiasis

Myopathy

Muscular Diseases

Myopathies

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-101942	Zegocractin	Inhibitor	99.96%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19408	Pyr10	Inhibitor	99.42%	否
HY-103310	MRS1845	Inhibitor	99.69%	否
HY-113618B	RO2959 monohydrochloride	Inhibitor	98.21%	否
HY-113618A	RO2959 hydrochloride	Inhibitor	/	否
HY-12521	GSK-5498A	Inhibitor	97.45%	否
HY-103071	GSK-5503A	Inhibitor	/	否
HY-RS09822	ORAI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ORAI1	VGNC	VGNC:44137
Rattus norvegicus	ORAI1	RGD	RGD:1311873
Mus musculus	ORAI1	MGD	MGI:1925542
Bos taurus	ORAI1	VGNC	VGNC:32443
Macaca mulatta	ORAI1	VGNC	VGNC:75464
Felis catus	ORAI1	VGNC	VGNC:63971

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ORAI1 - ORAI calcium release-activated calcium modulator 1 Gene

关于 ORAI1

功能概要

ORAI1 基因产物(1)

ORAI1 蛋白结构

ORAI1 蛋白互作信息

关联疾病

直系同源

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ORAI1 - ORAI calcium release-activated calcium modulator 1 Gene

关于 ORAI1

功能概要

ORAI1 基因产物(1)

ORAI1 蛋白结构

ORAI1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z