2. Gene
  3. ATP2C2 - ATPase secretory pathway Ca2+ transporting 2 Gene

ATP2C2 - ATPase secretory pathway Ca2+ transporting 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ATPase 分泌途径 Ca2+ 转运 2

种属: Homo sapiens

同用名: SPCA2

基因 ID: 9914 | 基因类型: protein coding

关于 ATP2C2

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,368,538-84,464,187 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 21 paralogues. Biased expression in colon (RPKM 16.5), skin (RPKM 9.9) and 12 other tissues.

功能概要

启用 P 型钙转运蛋白活性和 P 型锰转运蛋白活性。预计参与钙离子跨膜转运；细胞钙离子稳态；和锰离子传输。预测作用于乳腺上皮细胞发育的上游或内部；正调节钙离子输入；和蛋白质定位到质膜。预测位于跨高尔基网络膜。预计活跃于高尔基体膜；内质网；和质膜。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATP2C2 基因产物(3)

mRNA Protein Name
NM_001286527.3 NP_001273456.2 calcium-transporting ATPase type 2C member 2 isoform 1
NM_001291454.2 NP_001278383.1 calcium-transporting ATPase type 2C member 2 isoform 3
NM_014861.4 NP_055676.3 calcium-transporting ATPase type 2C member 2 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables P-type calcium transporter activity IDA
IDA: 通过直接分析推断
15677451 GOA
enables P-type manganese transporter activity IDA
IDA: 通过直接分析推断
15831496 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20887894 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATP2C2 蛋白结构

Cation_ATPase_N

Cation_ATPase_N: Cation transporter/ATPase, N-terminus (62 - 125)

E1-E2_ATPase

E1-E2_ATPase: E1-E2 ATPase (136 - 369)

Hydrolase

Hydrolase: haloacid dehalogenase-like hydrolase (374 - 686)

Cation_ATPase_C

Cation_ATPase_C: Cation transporting ATPase, C-terminus (756 - 928)

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  • 946 a.a.
蛋白主名 其他名称

calcium-transporting ATPase type 2C member 2

ATPase 2C2

ATP2C2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ATP2C2 O75185 ORAI1 Homo sapiens Q96D31
Anti Tag CoIP
20887894
种属内
ATP2C2 O75185 ORAI1 Homo sapiens Q96D31
Anti Bait CoIP
20887894
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyslexia
Benign Chronic Pemphigus

Hailey-Hailey Disease

Pemphigus, Benign Familial

Familial Benign Pemphigus

Benign Familial Pemphigus

Familial Benign Chronic Pemphigus

BCPM

HHD

Benign Chronic Familial Pemphigus Of Hailey-Hailey

Pemphigus, Chronic, Benign
Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder
Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder
Triple-Receptor Negative Breast Cancer
Expressive Language Disorder

Developmental Expressive Language Disorder
Specific Language Impairment

Language Impairment, Specific
Developmental Coordination Disorder

Motor Skills Disorders
Mixed Receptive-Expressive Language Disorder
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder
Speech Disorder

Speech Disorders
Stuttering

Stammering

Familial Persistent Stuttering

Stuttering, Familial Persistent 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01199 ATP2C2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ATP2C2 RGD RGD:620647
Macaca mulatta ATP2C2 VGNC VGNC:70149
Bos taurus ATP2C2 VGNC VGNC:26297
Canis familiaris ATP2C2 VGNC VGNC:38261
Mus musculus ATP2C2 MGD MGI:1916297
Felis catus ATP2C2 VGNC VGNC:60020
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