DDRGK1 - DDRGK domain containing 1 Gene

中文名称：含 DDRGK 域 1

种属: Homo sapiens

同用名: UFBP1; SEMDSH; C20orf116; dJ1187M17.3

基因 ID: 65992 | 基因类型: protein coding

关于 DDRGK1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,190,350-3,204,682 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 23.3), kidney (RPKM 21.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质与泛素折叠修饰符 1 结合通路的成分相互作用，有助于防止 ER 应激分泌组织的细胞凋亡。此外，编码的蛋白质调节核因子-#B 活性。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent Apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015]

DDRGK1 基因产物(1)

mRNA	Protein	Name
NM_023935.3	NP_076424.1	DDRGK domain-containing protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: 通过直接分析推断	23675531	GOA
enables UFM1-modified protein reader activity	IDA IDA: 通过直接分析推断	36121123	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20018847	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: 通过物理相互作用推断	25219498	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cartilage development	IMP IMP: 通过突变表型推断	28263186	GOA
involved in negative regulation of IRE1-mediated unfolded protein response	IDA IDA: 通过直接分析推断	28128204	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	23675531	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	28263186	GOA
involved in positive regulation of I-kappaB phosphorylation	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of metallopeptidase activity	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	23675531	GOA
involved in positive regulation of proteolysis involved in protein catabolic process	IDA IDA: 通过直接分析推断	36543799	GOA
involved in positive regulation of reticulophagy	IDA IDA: 通过直接分析推断	36543799	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23675531	GOA
involved in protein K69-linked ufmylation	IDA IDA: 通过直接分析推断	25219498	GOA
involved in protein localization to endoplasmic reticulum	IDA IDA: 通过直接分析推断	32160526	GOA
involved in protein ufmylation	IDA IDA: 通过直接分析推断	32160526	GOA
involved in protein ufmylation	IMP IMP: 通过突变表型推断	30626644	GOA
involved in regulation of intracellular estrogen receptor signaling pathway	IDA IDA: 通过直接分析推断	25219498	GOA
involved in regulation of protein stability	IDA IDA: 通过直接分析推断	28128204	GOA
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	37595036	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	28128204	GOA
involved in reticulophagy	IDA IDA: 通过直接分析推断	32160526	GOA
involved in ribosome disassembly	IDA IDA: 通过直接分析推断	38383785	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	20018847	GOA
is active in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	36543799	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	20228063	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDRGK1 蛋白结构

DDRGK

0
100
200
314 a.a.

蛋白主名

其他名称

DDRGK domain-containing protein 1

Dashurin

DDRGK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DDRGK1	Q96HY6	UFL1	Homo sapiens	O94874	Anti Tag CoIP	33961781
种属内	DDRGK1	Q96HY6	UFL1	Homo sapiens	O94874	Anti Tag CoIP	37595036
种属内	DDRGK1	Q96HY6	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spondyloepimetaphyseal Dysplasia, Shohat Type

Semd, Shohat Type	SEMDSH
Spondyloepimetaphyseal Dysplasia Shohat Type	Semd Shohat Type

Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal

Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type	Beukes Familial Hip Dysplasia
BFHD	Cilliers-Beighton Syndrome
Osteoarthropathy, Premature Degenerative, Of Hip	Premature Degenerative Osteoarthropathy Of The Hip
BHD	Beukes Type Hip Dysplasia
Hip Dysplasia Beukes Type	Premature Degenerative Osteoarthropathy
Dysplasia, Hip, Beukes Type

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Developmental And Epileptic Encephalopathy 44

DEE44	Epileptic Encephalopathy, Early Infantile, 44
Eiee44	Developmental And Epileptic Encephalopathy, 44
Early Infantile Epileptic Encephalopathy 44	Encephalopathy, Epileptic, Early Infantile, Type 44

Metachondromatosis

METCDS

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03626	DDRGK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DDRGK1	MGD	MGI:1924256
Bos taurus	DDRGK1	VGNC	VGNC:27954
Rattus norvegicus	DDRGK1	RGD	RGD:1309979
Canis familiaris	DDRGK1	VGNC	VGNC:39843
Macaca mulatta	DDRGK1	VGNC	VGNC:107785
Felis catus	DDRGK1	VGNC	VGNC:80081

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DDRGK1 - DDRGK domain containing 1 Gene

关于 DDRGK1

功能概要

DDRGK1 基因产物(1)

DDRGK1 蛋白结构

DDRGK1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DDRGK1 - DDRGK domain containing 1 Gene

关于 DDRGK1

功能概要

DDRGK1 基因产物(1)

DDRGK1 蛋白结构

DDRGK1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z