2. Gene
  3. TAP1 - transporter 1, ATP binding cassette subfamily B member Gene

TAP1 - transporter 1, ATP binding cassette subfamily B member Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转运蛋白 1，ATP 结合盒亚家族 B 成员

种属: Homo sapiens

同用名: APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*0102N

基因 ID: 6890 | 基因类型: protein coding

关于 TAP1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,845,209-32,853,704 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 217 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 57.6), appendix (RPKM 54.1) and 24 other tissues.

功能概要

由该基因编码的膜相关蛋白是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。该蛋白是 MDR/TAP 亚家族的成员。 MDR/TAP 亚家族的成员参与了多药耐药性。由该基因编码的蛋白质参与将降解的胞质肽泵送穿过内质网进入 I 类分子组装的膜结合区室。该基因的突变可能与强直性脊柱炎、胰岛素依赖型糖尿病和乳糜泻有关。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 5 月]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic Peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

TAP1 基因产物(2)

mRNA Protein Name
NM_000593.6 NP_000584.3 antigen peptide transporter 1 isoform 1
NM_001292022.2 NP_001278951.1 antigen peptide transporter 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ABC-type peptide antigen transporter activity IDA
IDA: 通过直接分析推断
11133832 GOA
enables ABC-type peptide antigen transporter activity IMP
IMP: 通过突变表型推断
25656091 GOA
enables ADP binding IDA
IDA: 通过直接分析推断
11532960 GOA
enables ATP binding IDA
IDA: 通过直接分析推断
7673167 GOA
enables ATP binding IMP
IMP: 通过突变表型推断
15793001 GOA
enables MHC class Ib protein binding IPI
IPI: 通过物理相互作用推断
10605026 GOA
enables TAP2 binding IPI
IPI: 通过物理相互作用推断
1538751 GOA
enables peptide antigen binding IDA
IDA: 通过直接分析推断
7500034 GOA
contributes to peptide transmembrane transporter activity IGI
IGI: 通过遗传相互作用推断
7673167 GOA
enables peptide transmembrane transporter activity IMP
IMP: 通过突变表型推断
17418234 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12213826 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I IDA
IDA: 通过直接分析推断
11133832 GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I IMP
IMP: 通过突变表型推断
11133832 GOA
involved in cytosol to endoplasmic reticulum transport IMP
IMP: 通过突变表型推断
7538543 GOA
involved in peptide transport IMP
IMP: 通过突变表型推断
11133832 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MHC class I peptide loading complex IDA
IDA: 通过直接分析推断
17947644 GOA
part of TAP complex IDA
IDA: 通过直接分析推断
11133832 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
7673167 GOA
located in membrane IDA
IDA: 通过直接分析推断
8955196 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAP1 蛋白结构

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (249 - 518)

ABC_tran

ABC_tran: ABC transporter (581 - 731)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
蛋白主名 其他名称

antigen peptide transporter 1

ABC transporter, MHC 1

TAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAP1 Q03518 CALR Homo sapiens P27797
Anti Bait CoIP
17055437
种属内
TAP1 Q03518 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
种属内
TAP1 Q03518 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
种属内
TAP1 Q03518 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
种属内
TAP1 Q03518 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
TAP1 Q03518 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
TAP1 Q03518 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
种属内
TAP1 Q03518 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
种属内
TAP1 Q03518 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
种属内
TAP1 Q03518 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
种属内
TAP1 Q03518 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
种属内
TAP1 Q03518 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
种属内
TAP1 Q03518 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
种属内
TAP1 Q03518 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
种属内
TAP1 Q03518 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
种属内
TAP1 Q03518 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
种属内
TAP1 Q03518 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
种属内
TAP1 Q03518 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
种属内
TAP1 Q03518 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
种属内
TAP1 Q03518 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 P4HB Homo sapiens P07237
Anti Bait CoIP
17055437
种属内
TAP1 Q03518 THOC5 Homo sapiens Q13769
Y2H
19165146
种属内
TAP1 Q03518 THOC5 Homo sapiens Q13769
Pull Down
19165146
种属内
TAP1 Q03518 TAP2 Homo sapiens Q03519
Anti Bait CoIP
19201886
种属内
TAP1 Q03518 TAP2 Homo sapiens Q03519
Crosslink
19297616
种属内
TAP1 Q03518 TAP2 Homo sapiens Q03519
Anti Bait CoIP
17055437
种属内
TAP1 Q03518 TAP2 Homo sapiens Q03519
Anti Tag CoIP
18802093
种属内
TAP1 Q03518 TAP2 Homo sapiens Q03519
Pull Down
26789246
种属内
TAP1 Q03518 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属内
TAP1 Q03518 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
TAP1 Q03518 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属内
TAP1 Q03518 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
种属内
TAP1 Q03518 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属内
TAP1 Q03518 TAPBP Homo sapiens O15533
Anti Tag CoIP
18802093
种属内
TAP1 Q03518 TAPBP Homo sapiens O15533
Anti Bait CoIP
19201886
种属内
TAP1 Q03518 TAPBP Homo sapiens O15533
Anti Bait CoIP
17055437
种属内
TAP1 Q03518 PDIA3 Homo sapiens P30101
Anti Bait CoIP
17055437
种属内
TAP1 Q03518 PDIA3 Homo sapiens P30101
Pull Down
30833792
种属间
TAP1 Q03518 gN Bovine herpesvirus 1.1 Q77CE4
Anti Bait CoIP
18802093
种属间
TAP1 Q03518 gN Bovine herpesvirus 1.1 Q77CE4
Anti Tag CoIP
18802093
种属间
TAP1 Q03518 bnl2a_ebvb9 Epstein-Barr virus P0C739
Anti Bait CoIP
19201886
种属间
TAP1 Q03518 bnl2a_ebvb9 Epstein-Barr virus P0C739
IF
19201886
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Immunodeficiency By Defective Expression Of Mhc Class I

Bare Lymphocyte Syndrome Type 1

Mhc Class I Deficiency
Spondylitis
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications
Diabetes Mellitus

Diabetes
Suppressor Of Tumorigenicity 3

Cervical Carcinoma

ST3

Tumor-Suppressor Gene, Hela Cell Type

Tshl

Cervical Carcinoma, Tumor-Suppressor Gene Involved In

Ccts

Cervix Carcinoma
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P5865 Tap1a Inhibitor / 否
HY-RS14201 TAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TAP1 VGNC VGNC:35598
Mus musculus TAP1 MGD MGI:98483
Rattus norvegicus TAP1 RGD RGD:3817
Canis familiaris TAP1 VGNC VGNC:47105
Others TAP1 NCBI
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