2. Gene
  3. PDIA3 - protein disulfide isomerase family A member 3 Gene

PDIA3 - protein disulfide isomerase family A member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白质二硫键异构酶家族 A 成员 3

种属: Homo sapiens

同用名: P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n

基因 ID: 2923 | 基因类型: protein coding

关于 PDIA3

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,746,438-43,773,278 (from NCBI)

This gene has 33 transcripts (splice variants), 222 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 333.0), prostate (RPKM 175.9) and 25 other tissues.

功能概要

该基因编码一种内质网蛋白，该蛋白与凝集素伴侣钙网蛋白和钙连接蛋白相互作用，以调节新合成糖蛋白的折叠。这种蛋白质曾被认为是一种磷脂酶；然而，已经证明该蛋白质实际上具有蛋白质二硫键异构酶活性。据认为，凝集素和这种蛋白质的复合物通过促进其糖蛋白底物中二硫键的形成来介导蛋白质折叠。这种蛋白质还起到分子伴侣的作用，可防止蛋白质聚集体的形成。[RefSeq 提供，2016 年 12 月]

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

PDIA3 基因产物(2)

mRNA Protein Name
NM_005313.5 NP_005304.3 protein disulfide-isomerase A3 precursor
NM_005313.5 NP_005304.3 protein disulfide-isomerase A3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16905107 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15896298 GOA
enables protein-disulfide reductase activity IDA
IDA: 通过直接分析推断
16677074 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptide antigen assembly with MHC class I protein complex IDA
IDA: 通过直接分析推断
17603487 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MHC class I peptide loading complex IDA
IDA: 通过直接分析推断
17947644 GOA
part of Tapasin-ERp57 complex IPI
IPI: 通过物理相互作用推断
19119025 GOA
located in cell surface IDA
IDA: 通过直接分析推断
19995400 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23826168 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
19995400 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDIA3 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (27 - 131)

Thioredoxin_6

Thioredoxin_6: Thioredoxin-like domain (160 - 355)

Thioredoxin

Thioredoxin: Thioredoxin (378 - 482)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

protein disulfide-isomerase A3

58 kDa glucose-regulated protein

58 kDa microsomal protein

ER protein 57

ER protein 60

disulfide isomerase ER-60

endoplasmic reticulum P58

endoplasmic reticulum resident protein 57

endoplasmic reticulum resident protein 60

epididymis secretory protein Li 269

epididymis secretory sperm binding protein Li 93n

glucose regulated protein, 58kDa

phospholipase C-alpha

protein disulfide isomerase-associated 3

PDIA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PDIA3 P30101 PRDX4 Homo sapiens Q13162
Enzymatic Study
21057456
Intra PDIA3 P30101 STIM1 Homo sapiens Q13586
SPR
21941299
Intra PDIA3 P30101 STIM1 Homo sapiens Q13586
IF
21941299
Intra PDIA3 P30101 APP Homo sapiens P05067
Pull Down
15896298
Cross PDIA3 P30101 CANX Canis familiaris P24643
NMR
16905107
Cross PDIA3 P30101 CANX Canis familiaris P24643
ITC
16905107
Cross PDIA3 P30101 Calr Rattus norvegicus P18418
Pull Down
22665516
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Granulomatous Orchitis

Non-Specific Granulomatous Orchitis
Macular Degeneration, Age-Related, 15

Age Related Macular Degeneration 15

ARMD15

Macular Degeneration, Age-Related, 15, Susceptibility To

Macular Degeneration, Age-Related, Type 15
Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease

CJD

Bovine Spongiform Encephalopathy

Vcjd

Inherited Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Familial

Creutzfeldt Jakob Disease

Creutzfeldt-Jacob Disease

Creutzfeldt Jacob Disease

Sporadic Creutzfeldt-Jakob Disease

Encephalopathy, Bovine Spongiform

Creutzfeldt-Jakob Disease, Variant, Resistance To

Creutzfeldt-Jakob Disease, Variant

Creutzfeldt Jacob Syndrome

Jakob-Creutzfeldt Disease

Subacute Spongiform Encephalopathy

Transmissible Virus Dementia

New Variant Of Cjd

Nv-Cjd

Variant Cjd

Variant Creutzfeldt-Jacob Disease

Sporadic Cjd

Inherited Cjd

Acquired Creutzfeldt-Jakob Disease

Variant Mcj

Encephalopathy Bovine Spongiform

Familial Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Syndrome

New Variant Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Sporadic

Acquired Cjd

Scjd - [Sporadic Creutzfeldt-Jakob Disease]

Idiopathic Creutzfeldt-Jakob Disease

Creutzfeld-Jakob Disease Nos

Vcjd - [Variant Creutzfeldt-Jakob Disease]
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0177 Diosgenin Inhibitor 99.35% 否
HY-100432 LOC14 ≥98.0% 否
HY-122895 E64FC26 98.10% 否
HY-122895A (E/Z)-E64FC26 98.09% 否
HY-151286 Antitumor agent-73 Inhibitor / 否
HY-RS10266 PDIA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10267 Pdia3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10268 Pdia3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PDIA3 VGNC VGNC:67483
Mus musculus PDIA3 MGD MGI:95834
Bos taurus PDIA3 VGNC VGNC:32697
Canis familiaris PDIA3 VGNC VGNC:103695
Rattus norvegicus PDIA3 RGD RGD:68430
Macaca mulatta PDIA3 VGNC VGNC:75905
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