1. Gene
  2. ERGIC3 - ERGIC and golgi 3 Gene

ERGIC3 - ERGIC and golgi 3 Gene

中文名称:ERGIC 和高尔基体 3

种属: Homo sapiens

同用名: Erv46; CGI-54; C2orf47; PRO0989; C20orf47; NY-BR-84; SDBCAG84; dJ477O4.2

基因 ID: 51614 | 基因类型: protein coding

关于 ERGIC3

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,542,078-35,557,634 (from NCBI)

This gene has 19 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 113.7), testis (RPKM 112.2) and 25 other tissues.

功能概要

预测参与内质网至高尔基体囊泡介导的转运和逆行囊泡介导的转运,高尔基体至内质网。位于膜内。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ERGIC3 基因产物(2)

mRNA Protein Name
NM_015966.3 NP_057050.1 endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform b
NM_198398.2 NP_938408.1 endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15308636 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: 通过直接分析推断
31142615 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: 通过突变表型推断
31142615 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of retrograde transporter complex, Golgi to ER IPI
IPI: 通过物理相互作用推断
31142615 GOA
part of transporter complex IPI
IPI: 通过物理相互作用推断
31142615 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ERGIC3 蛋白结构

ERGIC_N

ERGIC_N: Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) (6 - 101)

COPIIcoated_ERV

COPIIcoated_ERV: Endoplasmic reticulum vesicle transporter (145 - 363)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
蛋白主名 其他名称

endoplasmic reticulum-Golgi intermediate compartment protein 3

endoplasmic reticulum-localized protein ERp43

ERGIC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ERGIC3 Q9Y282 MARCHF2 Homo sapiens Q9P0N8
Anti Tag CoIP
31142615
种属内
ERGIC3 Q9Y282 HP Homo sapiens P00738
Anti Bait CoIP
31142615
种属内
ERGIC3 Q9Y282 SFXN5 Homo sapiens Q8TD22
Anti Tag CoIP
33961781
种属内
ERGIC3 Q9Y282 VMP1 Homo sapiens Q96GC9
Anti Tag CoIP
33961781
种属内
ERGIC3 Q9Y282 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 TMEM222 Homo sapiens Q9H0R3
Y2H Prey Pooling
32296183
种属内
ERGIC3 Q9Y282 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 ERGIC2 Homo sapiens Q96RQ1
Anti Tag CoIP
31142615
种属内
ERGIC3 Q9Y282 ERGIC2 Homo sapiens Q96RQ1
Anti Tag CoIP
33961781
种属内
ERGIC3 Q9Y282 UNC50 Homo sapiens Q53HI1
Y2H Array
32296183
种属内
ERGIC3 Q9Y282 ERGIC1 Homo sapiens Q969X5
Anti Tag CoIP
31142615
种属内
ERGIC3 Q9Y282 ERGIC1 Homo sapiens Q969X5
IF
15308636
种属内
ERGIC3 Q9Y282 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
种属内
ERGIC3 Q9Y282 SERPINA1 Homo sapiens P01009
Anti Bait CoIP
31142615
种属内
ERGIC3 Q9Y282 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1

Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

Atr Syndrome Linked To Chromosome 16

Atr Syndrome, Deletion Type

Atr-16 Syndrome

Alpha Thalassemia-Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy

Bafme

Benign Adult Familial Myoclonic Epilepsy

Fame

Familial Cortical Myoclonic Tremor And Epilepsy

Fcmte

Adcme

Autosomal Dominant Cortical Myoclonus And Epilepsy

Fam

Epilepsy, Myoclonic, Familial Adult

Epilepsy, Myoclonic, Benign Adult Familial, Type 2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ERGIC3 VGNC VGNC:72274
Rattus norvegicus ERGIC3 RGD RGD:1308144
Mus musculus ERGIC3 MGD MGI:1913616
Bos taurus ERGIC3 VGNC VGNC:28580
Canis familiaris ERGIC3 VGNC VGNC:40452
Felis catus ERGIC3 VGNC VGNC:61941