VMP1 - vacuole membrane protein 1 Gene

中文名称：液泡膜蛋白 1

种属: Homo sapiens

同用名: EPG3; TANGO5; TMEM49

关于 VMP1

功能概要

该基因编码一种跨膜蛋白，在自噬过程中起着关键的调节作用。即使在营养丰富的条件下，培养细胞中编码蛋白的异位过表达也会引发自噬。该基因在受胰腺炎影响的腺泡细胞中过度表达，其中编码的蛋白质在称为酶噬的过程中介导潜在有害的活化酶原颗粒的隔离和降解。[RefSeq 提供，2016 年 7 月]

This gene encodes a transmembrane protein that plays a key regulatory role in the process of Autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers Autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]