SELENOK - selenoprotein K Gene

中文名称：硒蛋白 K

种属: Homo sapiens

同用名: SELK; HSPC030; HSPC297

关于 SELENOK

功能概要

该基因编码的蛋白质属于硒蛋白 K 家族。它是一种跨膜蛋白，位于内质网 (ER) 中，参与错误折叠的糖基化蛋白的 ER 相关降解 (ERAD) 。它还具有保护细胞免受 ER 应激诱导的细胞凋亡的作用。小鼠基因敲除研究表明该基因在促进免疫细胞中 CA (2+) 通量和建立有效免疫反应方面的重要性。这种蛋白质是一种硒蛋白，含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。已在 6 号和 19 号染色体上鉴定出该基因座的假基因。[RefSeq 提供，2017 年 8 月]

The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced Apoptosis. Knockout studies in mice show the importance of this gene in promoting CA(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]