2. Gene
  3. AMIGO1 - adhesion molecule with Ig like domain 1 Gene

AMIGO1 - adhesion molecule with Ig like domain 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 Ig 样结构域 1 的粘附分子

种属: Homo sapiens

同用名: ALI2; AMIGO; AMIGO-1

基因 ID: 57463 | 基因类型: protein coding

关于 AMIGO1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,504,178-109,509,727 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 9.3), adrenal (RPKM 6.7) and 24 other tissues.

功能概要

预测可启用钾通道调节剂活性。预计参与多个过程，包括通过质膜细胞粘附分子的异嗜性细胞间粘附；通过质膜粘附分子的嗜同细胞粘附；和神经系统发育。预计在突触组装的正调节上游或正调节内起作用。预测位于树突和神经细胞体膜上。预计是膜的组成部分。预测与电压门控钾通道复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Potassium Channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in dendrite and neuronal cell body membrane. Predicted to be integral component of membrane. Predicted to colocalize with voltage-gated Potassium Channel complex. [provided by Alliance of Genome Resources, Apr 2022]

AMIGO1 基因产物(1)

mRNA Protein Name
NM_020703.4 NP_065754.2 amphoterin-induced protein 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AMIGO1 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (110 - 170)

LRR_1

LRR_1: Leucine Rich Repeat (186 - 208)

V-set

V-set: Immunoglobulin V-set domain (285 - 357)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

amphoterin-induced protein 1

alivin-2

AMIGO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AMIGO1 Q86WK6 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 PROM2 Homo sapiens Q8N271
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 FAM3C Homo sapiens Q92520
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 HHATL Homo sapiens Q9HCP6
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 TMEM79 Homo sapiens Q9BSE2
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra AMIGO1 Q86WK6 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tungiasis

Tunga Penetrans Infestation

Chigger Flea

S Penetrans

Sarcopsylla Penetrans

T Penetrans

Tunga Penetrans

Sand-Flea Infestation

Jiggers Infestation

Chigoe Infestation

Jigger Disease
Developmental And Epileptic Encephalopathy 26

DEE26

Epileptic Encephalopathy, Early Infantile, 26

Eiee26

Early Infantile Epileptic Encephalopathy 26

Developmental And Epileptic Encephalopathy, 26

Encephalopathy, Epileptic, Early Infantile, Type 26
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00657 AMIGO1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus AMIGO1 MGD MGI:2653612
Felis catus AMIGO1 VGNC VGNC:59765
Rattus norvegicus AMIGO1 RGD RGD:1303079
Bos taurus AMIGO1 VGNC VGNC:25865
Canis familiaris AMIGO1 VGNC VGNC:37831
Macaca mulatta AMIGO1 VGNC VGNC:69653
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