2. Gene
  3. PROM2 - prominin 2 Gene

PROM2 - prominin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：prominin 2

种属: Homo sapiens

同用名: PROML2

基因 ID: 150696 | 基因类型: protein coding

关于 PROM2

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,274,449-95,291,302 (from NCBI)

This gene has 11 transcripts (splice variants), 191 orthologues and 1 paralogue. Biased expression in skin (RPKM 29.4), esophagus (RPKM 22.9) and 11 other tissues.

功能概要

该基因编码 pentaspan 膜糖蛋白的 prominin 家族成员。编码的蛋白质定位于基底上皮细胞，并可能参与质膜微域的组织。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PROM2 基因产物(4)

mRNA Protein Name
NM_001165977.3 NP_001159449.1 prominin-2 isoform 1 precursor
NM_001165978.3 NP_001159450.1 prominin-2 isoform 1 precursor
NM_001321070.2 NP_001307999.1 prominin-2 isoform 2
NM_144707.4 NP_653308.2 prominin-2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of caveolin-mediated endocytosis IDA
IDA: 通过直接分析推断
23583380 GOA
involved in negative regulation of pinocytosis IDA
IDA: 通过直接分析推断
23583380 GOA
involved in positive regulation of cell projection organization IDA
IDA: 通过直接分析推断
23583380 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
23583380 GOA
involved in regulation of GTPase activity IDA
IDA: 通过直接分析推断
23583380 GOA
NOT involved in regulation of clathrin-dependent endocytosis IDA
IDA: 通过直接分析推断
23583380 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell projection IDA
IDA: 通过直接分析推断
23583380 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PROM2 蛋白结构

Prominin

Prominin: Prominin (19 - 816)

  • 0
  • 200
  • 400
  • 600
  • 834 a.a.
蛋白主名 其他名称

prominin-2

prominin-like protein 2

PROM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PROM2 Q8N271 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra PROM2 Q8N271 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra PROM2 Q8N271 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra PROM2 Q8N271 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra PROM2 Q8N271 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Maxillary Cancer

Maxillary Neoplasm

Maxillary Neoplasms

Upper Jaw Bone Cancer
Jaw Cancer

Jaw Neoplasms

Jaw Neoplasm

Neoplasm Of Jaw

Cancer Of Jaw
Retinal Degeneration

Degeneration Of Retina
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11199 PROM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PROM2 MGD MGI:2138997
Macaca mulatta PROM2 VGNC VGNC:106200
Canis familiaris PROM2 VGNC VGNC:45013
Bos taurus PROM2 VGNC VGNC:33365
Felis catus PROM2 VGNC VGNC:64367
Rattus norvegicus PROM2 RGD RGD:621435
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