NINJ2 - ninjurin 2 Gene

中文名称：忍者 2

种属: Homo sapiens

基因 ID: 4815 | 基因类型: protein coding

关于 NINJ2

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:564,296-663,445 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in lung (RPKM 12.3), bone marrow (RPKM 6.0) and 21 other tissues.

功能概要

该基因编码的蛋白质属于 ninjurin (用于诱发神经损伤) 家族。它是一种细胞表面粘附蛋白，在受损神经远端周围的雪旺细胞中上调，并促进神经突生长，因此可能在神经损伤后的神经再生中发挥作用。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

NINJ2 基因产物(4)

mRNA	Protein	Name
NM_001294345.2	NP_001281274.1	ninjurin-2 isoform 2
NM_001294346.2	NP_001281275.1	ninjurin-2 isoform 3
NM_001367996.1	NP_001354925.1	ninjurin-2 isoform 3
NM_016533.6	NP_057617.3	ninjurin-2 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables membrane destabilizing activity	IDA IDA: 通过直接分析推断	33472215	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in cytolysis	IDA IDA: 通过直接分析推断	33472215	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NINJ2 蛋白结构

Ninjurin

0
100
188 a.a.

蛋白主名

其他名称

ninjurin-2

nerve injury-induced protein 2

NINJ2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NINJ2	Q9NZG7	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	IFNGR1	Homo sapiens	P15260	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	IFNGR1	Homo sapiens	P15260	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
种属内	NINJ2	Q9NZG7	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	GJA1	Homo sapiens	P17302	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	GJA1	Homo sapiens	P17302	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	MR1	Homo sapiens	Q95460-2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	MR1	Homo sapiens	Q95460-2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CEACAM3	Homo sapiens	P40198	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CEACAM3	Homo sapiens	P40198	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLC66A1	Homo sapiens	Q6ZP29-3	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	SLC66A1	Homo sapiens	Q6ZP29-3	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
种属内	NINJ2	Q9NZG7	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	EREG	Homo sapiens	O14944	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	EREG	Homo sapiens	O14944	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CHODL	Homo sapiens	Q9H9P2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CHODL	Homo sapiens	Q9H9P2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	PIGP	Homo sapiens	P57054	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	PIGP	Homo sapiens	P57054	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TM4SF20	Homo sapiens	Q53R12	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TM4SF20	Homo sapiens	Q53R12	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	GPR42	Homo sapiens	O15529	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLAMF8	Homo sapiens	Q9P0V8	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	SLAMF8	Homo sapiens	Q9P0V8	Validated Y2H	32296183
种属内	NINJ2	Q9NZG7	SLAMF8	Homo sapiens	Q9P0V8	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	VSIG1	Homo sapiens	Q86XK7	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	VSIG1	Homo sapiens	Q86XK7	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	FCGRT	Homo sapiens	P55899	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	FCGRT	Homo sapiens	P55899	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CD69	Homo sapiens	Q07108	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CD69	Homo sapiens	Q07108	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	M6PR	Homo sapiens	P20645	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	M6PR	Homo sapiens	P20645	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	EBP	Homo sapiens	Q15125	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	PVR	Homo sapiens	P15151	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	CLEC7A	Homo sapiens	Q9BXN2	Y2H Array	25416956
种属内	NINJ2	Q9NZG7	FCRL4	Homo sapiens	Q96PJ5	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	FCRL4	Homo sapiens	Q96PJ5	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
种属内	NINJ2	Q9NZG7	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM9	Homo sapiens	Q9P0T7	Validated Y2H	32296183
种属内	NINJ2	Q9NZG7	TMEM9	Homo sapiens	Q9P0T7	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM9	Homo sapiens	Q9P0T7	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	MGST3	Homo sapiens	O14880	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ICAM3	Homo sapiens	P32942	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ICAM3	Homo sapiens	P32942	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	25416956
种属内	NINJ2	Q9NZG7	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	CD79A	Homo sapiens	P11912	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	NINJ2	Q9NZG7	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
种属内	NINJ2	Q9NZG7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
种属内	NINJ2	Q9NZG7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Inflammatory Bowel Disease 4

IBD4

Idiopathic Peripheral Autonomic Neuropathy

Acrocallosal Syndrome

ACLS	Schinzel Acrocallosal Syndrome
Joubert Syndrome 12	Schinzel Syndrome 1
Acrocallosal Syndrome, Schinzel Type	Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum
Acs	Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly
Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum	JBTS12
Acrocallosal Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09299	NINJ2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NINJ2	VGNC	VGNC:32079
Canis familiaris	NINJ2	VGNC	VGNC:43812
Felis catus	NINJ2	VGNC	VGNC:68496
Mus musculus	NINJ2	MGD	MGI:1352751
Rattus norvegicus	NINJ2	RGD	RGD:620552

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