1. Gene
  2. RNASEK - ribonuclease K Gene

RNASEK - ribonuclease K Gene

中文名称:核糖核酸酶 K

种属: Homo sapiens

基因 ID: 440400 | 基因类型: protein coding

关于 RNASEK

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,012,624-7,014,532 (from NCBI)

This gene has 10 transcripts (splice variants) and 229 orthologues. Ubiquitous expression in adrenal (RPKM 84.0), kidney (RPKM 67.2) and 25 other tissues.

功能概要

启用核糖核酸内切酶活性。预计参与 RNA 磷酸二酯键水解、核酸内切。预计是膜的组成部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables endoribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNASEK 基因产物(1)

mRNA Protein Name
NM_001004333.5 NP_001004333.3 ribonuclease kappa
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA endonuclease activity IDA
IDA: 通过直接分析推断
17881363 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosomal lumen acidification IPI
IPI: 通过物理相互作用推断
26212330 GOA
involved in proton transmembrane transport IPI
IPI: 通过物理相互作用推断
26212330 GOA
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
26212330 GOA
involved in receptor-mediated endocytosis of virus by host cell IMP
IMP: 通过突变表型推断
26212330 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
33065002 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

ribonuclease kappa

RNase kappa

RNASEK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RNASEK Q6P5S7 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra RNASEK Q6P5S7 ARV1 Homo sapiens Q9H2C2
Validated Y2H
32296183
Intra RNASEK Q6P5S7 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
Intra RNASEK Q6P5S7 ZDHHC21 Homo sapiens Q8IVQ6
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra RNASEK Q6P5S7 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra RNASEK Q6P5S7 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra RNASEK Q6P5S7 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra RNASEK Q6P5S7 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra RNASEK Q6P5S7 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra RNASEK Q6P5S7 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra RNASEK Q6P5S7 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rift Valley Fever

Rfv - [Rift Valley Fever]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RNASEK MGD MGI:106369
Felis catus RNASEK VGNC VGNC:64659
Bos taurus RNASEK VGNC VGNC:34002
Rattus norvegicus RNASEK RGD RGD:1305687
Canis familiaris RNASEK VGNC VGNC:54351