FXYD6 - FXYD domain containing ion transport regulator 6 Gene

中文名称：含 FXYD 域离子传输调节因子 6

种属: Homo sapiens

基因 ID: 53826 | 基因类型: protein coding

关于 FXYD6

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,836,981-117,877,430 (from NCBI)

This gene has 17 transcripts (splice variants), 152 orthologues and 6 paralogues. Broad expression in brain (RPKM 186.7), ovary (RPKM 91.7) and 16 other tissues.

功能概要

该基因编码跨膜蛋白 FXYD 家族的成员。这种特殊的蛋白质编码磷酸化蛋白，它可能影响 Na,K-ATPase 的活性。已经描述了编码相同蛋白质的多个选择性剪接的转录物变体。已在 10 号染色体和 X 号染色体上鉴定出相关假基因。已在该基因座与下游钠/钾转运 ATP 酶亚基伽玛 (FXYD2，GeneID 486) 基因座之间观察到通读转录本。[RefSeq 提供，2011 年 2 月]

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

FXYD6 基因产物(5)

mRNA	Protein	Name
NM_001164831.3	NP_001158303.1	FXYD domain-containing ion transport regulator 6 precursor
NM_001164832.3	NP_001158304.1	FXYD domain-containing ion transport regulator 6 precursor
NM_001164836.3	NP_001158308.1	FXYD domain-containing ion transport regulator 6 precursor
NM_001164837.3	NP_001158309.1	FXYD domain-containing ion transport regulator 6 precursor
NM_022003.4	NP_071286.1	FXYD domain-containing ion transport regulator 6 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FXYD6 蛋白结构

ATP1G1_PLM_MAT8

0
95 a.a.

蛋白主名

其他名称

FXYD domain-containing ion transport regulator 6

phosphohippolin

FXYD6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FXYD6	Q9H0Q3	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	RHBDL1	Homo sapiens	O75783	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	RHBDL1	Homo sapiens	O75783	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM72	Homo sapiens	A0PK05	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TMEM72	Homo sapiens	A0PK05	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SVOP	Homo sapiens	Q8N4V2	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SVOP	Homo sapiens	Q8N4V2	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	SLC47A1	Homo sapiens	Q96FL8	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC47A1	Homo sapiens	Q96FL8	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	APCDD1L	Homo sapiens	Q8NCL9	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	APCDD1L	Homo sapiens	Q8NCL9	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM154	Homo sapiens	Q6P9G4	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TMEM154	Homo sapiens	Q6P9G4	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC35E3	Homo sapiens	Q7Z769	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	RHCG	Homo sapiens	Q9UBD6	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	RHCG	Homo sapiens	Q9UBD6	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	RHCG	Homo sapiens	Q9UBD6	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	ELOVL2	Homo sapiens	Q9NXB9	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	ELOVL2	Homo sapiens	Q9NXB9	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	ELOVL2	Homo sapiens	Q9NXB9	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	FPR2	Homo sapiens	P25090	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	FPR2	Homo sapiens	P25090	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	GJA8	Homo sapiens	P48165	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	LHFPL2	Homo sapiens	Q6ZUX7	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	LHFPL2	Homo sapiens	Q6ZUX7	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	GPR42	Homo sapiens	O15529	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	OCIAD1	Homo sapiens	Q9NX40	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	OCIAD1	Homo sapiens	Q9NX40	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	OCIAD1	Homo sapiens	Q9NX40	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	EBP	Homo sapiens	Q15125	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	PEX12	Homo sapiens	O00623	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	25416956
种属内	FXYD6	Q9H0Q3	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	25416956
种属内	FXYD6	Q9H0Q3	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	25416956
种属内	FXYD6	Q9H0Q3	MGST3	Homo sapiens	O14880	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	FXYD6	Q9H0Q3	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	DERL2	Homo sapiens	Q9GZP9	Y2H Prey Pooling	32296183
种属内	FXYD6	Q9H0Q3	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	32296183
种属内	FXYD6	Q9H0Q3	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypomagnesemia 2, Renal

Renal Hypomagnesemia 2	HOMG2
Magnesium Wasting, Renal	Autosomal Dominant Primary Hypomagnesemia With Hypocalciuria
Magnesium Loss, Isolated Renal	Isolated Autosomal Dominant Hypomagnesemia
Isolated Renal Magnesium Wasting	Renal Hypomagnesemia Type 2
Hypomagnesemia 2	Dominant Renal Hypomagnesemia
Hypomagnesemia With Hypocalciuria	Isolated Renal Magnesium Loss
Renal Magnesium Wasting	Hypomagnesemia-2, Renal
Renal Hypomagnesemia, Dominant	Hypomagnesemia, Type 2, Renal

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05170	FXYD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FXYD6	RGD	RGD:69315
Mus musculus	FXYD6	MGD	MGI:1890226
Bos taurus	FXYD6	VGNC	VGNC:54871
Canis familiaris	FXYD6	VGNC	VGNC:56011

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