2. Gene
  3. SLC30A2 - solute carrier family 30 member 2 Gene

SLC30A2 - solute carrier family 30 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 30 成员 2

种属: Homo sapiens

同用名: TNZD; ZNT2; ZnT-2; PP12488

基因 ID: 7780 | 基因类型: protein coding

关于 SLC30A2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,037,252-26,046,118 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 19.5), kidney (RPKM 11.8) and 4 other tissues.

功能概要

该基因编码的蛋白质是一种锌转运蛋白，可作为同型二聚体。编码的蛋白质在将锌分泌到母乳中起作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2015 年 8 月]

The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

SLC30A2 基因产物(2)

mRNA Protein Name
NM_001004434.3 NP_001004434.1 zinc transporter 2 isoform 1
NM_032513.5 NP_115902.1 zinc transporter 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
22733820 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25657003 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
17349999 GOA
enables zinc:proton antiporter activity IDA
IDA: 通过直接分析推断
30893306 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in zinc export across plasma membrane IDA
IDA: 通过直接分析推断
19496757 GOA
involved in zinc ion import into lysosome IDA
IDA: 通过直接分析推断
17349999 GOA
involved in zinc ion import into lysosome IMP
IMP: 通过突变表型推断
25808614 GOA
involved in zinc ion import into organelle IDA
IDA: 通过直接分析推断
21289295 GOA
involved in zinc ion import into organelle IMP
IMP: 通过突变表型推断
22733820 GOA
involved in zinc ion import into secretory vesicle IDA
IDA: 通过直接分析推断
19496757 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17349999 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
19496757 GOA
located in late endosome IDA
IDA: 通过直接分析推断
17349999 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
25808614 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
21289295 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19496757 GOA
located in secretory vesicle IDA
IDA: 通过直接分析推断
19496757 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC30A2 蛋白结构

Cation_efflux

Cation_efflux: Cation efflux family (90 - 311)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

zinc transporter 2

solute carrier family 30 (zinc transporter), member 2

SLC30A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q08AM2
Y2H Array
25416956
Intra SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q08AM2
Y2H Prey Pooling
25416956
Intra SLC30A2 Q9BRI3 CCL4L1 Homo sapiens Q8NHW4
Y2H Prey Pooling
25416956
Intra SLC30A2 Q9BRI3 CCL4L1 Homo sapiens Q8NHW4
Y2H Array
25416956
Intra SLC30A2 Q9BRI3 SLC30A3 Homo sapiens Q99726
IF
25657003
Intra SLC30A2 Q9BRI3 SLC30A3 Homo sapiens Q99726
Anti Tag CoIP
26728129
Intra SLC30A2 Q9BRI3 SLC30A3 Homo sapiens Q99726
BiFC
25657003
Intra SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q9BZ11-2
Validated Y2H
25416956
Intra SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q9BZ11-2
Y2H Array
25416956
Intra SLC30A2 Q9BRI3 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 IL10RA Homo sapiens Q13651
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 IL10RA Homo sapiens Q13651
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC30A1 Homo sapiens Q9Y6M5
BiFC
25657003
Intra SLC30A2 Q9BRI3 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 MS4A13 Homo sapiens Q5J8X5
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SLC30A10 Homo sapiens Q6XR72
Anti Tag CoIP
26728129
Intra SLC30A2 Q9BRI3 SLC30A4 Homo sapiens O14863
BiFC
25657003
Intra SLC30A2 Q9BRI3 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 PCNX2 Homo sapiens A6NKB5-5
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 PCNX2 Homo sapiens A6NKB5-5
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TSPAN31 Homo sapiens Q12999
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TSPAN31 Homo sapiens Q12999
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SELL Homo sapiens P14151-2
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SELL Homo sapiens P14151-2
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 TAS2R5 Homo sapiens Q9NYW4
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TAS2R5 Homo sapiens Q9NYW4
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 TAS2R5 Homo sapiens Q9NYW4
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 PLPPR1 Homo sapiens Q8TBJ4
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 PLPPR1 Homo sapiens Q8TBJ4
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 TNFRSF12A Homo sapiens Q9NP84
Y2H Prey Pooling
25416956
Intra SLC30A2 Q9BRI3 TNFRSF12A Homo sapiens Q9NP84
Validated Y2H
25416956
Intra SLC30A2 Q9BRI3 TNFRSF12A Homo sapiens Q9NP84
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Validated Y2H
25416956
Intra SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Y2H Array
25416956
Intra SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Y2H Array
31515488
Intra SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Y2H Prey Pooling
25416956
Intra SLC30A2 Q9BRI3 KCNN4 Homo sapiens O15554
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 KCNN4 Homo sapiens O15554
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 EMP3 Homo sapiens P54852
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Array
31515488
Intra SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Prey Pooling
25416956
Intra SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Validated Y2H
25416956
Intra SLC30A2 Q9BRI3 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 CREB3 Homo sapiens O43889-2
Validated Y2H
25910212
Intra SLC30A2 Q9BRI3 CREB3 Homo sapiens O43889-2
Y2H Bait-Prey Pool
25910212
Intra SLC30A2 Q9BRI3 CREB3 Homo sapiens O43889-2
Y2H Array
25910212
Intra SLC30A2 Q9BRI3 GPR161 Homo sapiens Q8N6U8
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GPR161 Homo sapiens Q8N6U8
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 NDUFAF1 Homo sapiens Q9Y375
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 NDUFAF1 Homo sapiens Q9Y375
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 NDUFAF1 Homo sapiens Q9Y375
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 F11R Homo sapiens Q9Y624
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 F11R Homo sapiens Q9Y624
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25910212
Intra SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Array
25910212
Intra SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Bait-Prey Pool
25910212
Intra SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra SLC30A2 Q9BRI3 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra SLC30A2 Q9BRI3 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 FDPS Homo sapiens P14324
Y2H Prey Pooling
32296183
Intra SLC30A2 Q9BRI3 FDPS Homo sapiens P14324
Y2H Array
32296183
Cross SLC30A2 Q9BRI3 Tfrc Rattus norvegicus Q99376
Anti Tag CoIP
26728129
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Zinc Deficiency, Transient Neonatal

TNZD

Zinc Deficiency, Neonatal, Due To Low Breast Milk Zinc

Neonatal Zinc Deficiency Due To Low Breast Milk Zinc
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Hypermanganesemia With Dystonia 2

HMNDYT2

Dystonia-Parkinsonism-Hypermanganesemia Syndrome

Hypermanganesemia With Dystonia, Type 2
Hypermanganesemia With Dystonia

Familial Manganese-Induced Neurotoxicity

Hmndyt
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

Scd-Eds

EDSSPD3

Ehlers-Danlos Syndrome Spondylodysplastic Type 3

Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

Slc39a13-Related Speds

Slc39a13-Related Spondylodysplastic Eds

Spondylocheirodysplastic Ehlers-Danlos Syndrome

Speds-Slc39a13

Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Hypermanganesemia With Dystonia 1

Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

HMNDYT1

Hmdpc

Hypermanganesemia With Dystonia Polycythemia And Cirrhosis

Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease

Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Acrodermatitis
Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder
Menkes Disease

Copper Transport Disease

Menkes Syndrome

MNK

Kinky Hair Disease

Steely Hair Disease

Menkes Kinky-Hair Syndrome

Mk

Steely Hair Syndrome

Menkea Syndrome

Md

Menkes Kinky Hair Syndrome

Hypocupremia, Congenital

Kinky Hair Syndrome

X-Linked Copper Deficiency

Menkes Kinky Hair Disease
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13180 SLC30A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC30A2 VGNC VGNC:77452
Rattus norvegicus SLC30A2 RGD RGD:3707
Canis familiaris SLC30A2 VGNC VGNC:46347
Bos taurus SLC30A2 VGNC VGNC:34807
Mus musculus SLC30A2 MGD MGI:106637
Felis catus SLC30A2 VGNC VGNC:107622
Others SLC30A2 NCBI
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