SLC30A4 - solute carrier family 30 member 4 Gene

中文名称：溶质载体家族 30 成员 4

种属: Homo sapiens

同用名: ZNT4; znT-4

关于 SLC30A4

功能概要

锌是人体中第二丰富的微量金属。它是一种必需元素，既起到结构作用，如在 DNA 结合蛋白中形成锌指，又起到金属酶催化作用，如胰羧肽酶 (如 MIM 114852) 、碱性磷酸酶 (如 MIM 171760) ) 、各种脱氢酶和超氧化物歧化酶 (例如 MIM 147450) 。 SLC30A4 或 ZNT4 属于 ZNT 锌转运蛋白家族。 ZNT 参与将锌转运出细胞质并具有相似的结构，由 6 个跨膜结构域和富含组氨酸的细胞质环组成 (Huang 和 Gitschier，1997 [PubMed 9354792]) 。[OMIM 提供，2008 年 3 月]

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]