2. Gene
  3. SLC30A10 - solute carrier family 30 member 10 Gene

SLC30A10 - solute carrier family 30 member 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 30 成员 10

种属: Homo sapiens

同用名: ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10; HMNDYT1

基因 ID: 55532 | 基因类型: protein coding

关于 SLC30A10

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:219,910,445-219,959,098 (from NCBI)

This gene has 5 transcripts (splice variants), 171 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 12.8), liver (RPKM 7.9) and 4 other tissues.

功能概要

该基因在肝脏中高度表达，并可被锰诱导。它的蛋白质产物似乎对维持锰水平至关重要，并且对锰的特异性高于锌。功能突变的丧失似乎导致多形性表型，包括肌张力障碍和成人发作的帕金森症。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 3 月]

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

SLC30A10 基因产物(2)

mRNA Protein Name
NM_001376929.1 NP_001363858.1 zinc transporter 10 isoform 2
NM_018713.3 NP_061183.2 zinc transporter 10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium:manganese antiporter activity IDA
IDA: 通过直接分析推断
30755481 GOA
enables manganese ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
25319704 GOA
enables manganese ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
27226609 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26728129 GOA
NOT enables zinc ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
30755481 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
22427991 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to angiotensin IDA
IDA: 通过直接分析推断
22427991 GOA
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
26728129 GOA
NOT involved in intracellular copper ion homeostasis IDA
IDA: 通过直接分析推断
25319704 GOA
involved in intracellular manganese ion homeostasis IDA
IDA: 通过直接分析推断
25319704 GOA
involved in intracellular manganese ion homeostasis IMP
IMP: 通过突变表型推断
22341972 GOA
NOT involved in intracellular zinc ion homeostasis IDA
IDA: 通过直接分析推断
25319704 GOA
involved in intracellular zinc ion homeostasis IDA
IDA: 通过直接分析推断
22427991 GOA
NOT involved in intracellular zinc ion homeostasis IMP
IMP: 通过突变表型推断
27226609 GOA
involved in manganese ion export across plasma membrane IDA
IDA: 通过直接分析推断
25319704 GOA
involved in manganese ion export across plasma membrane IMP
IMP: 通过突变表型推断
27307044 GOA
involved in manganese ion transport IMP
IMP: 通过突变表型推断
22341972 GOA
acts upstream of positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
26728129 GOA
involved in zinc ion import into organelle IDA
IDA: 通过直接分析推断
22427991 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
22706290 GOA
located in early endosome IDA
IDA: 通过直接分析推断
26728129 GOA
located in early endosome membrane IDA
IDA: 通过直接分析推断
22427991 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
25319704 GOA
located in recycling endosome IDA
IDA: 通过直接分析推断
26728129 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
22427991 GOA
NOT located in synaptic vesicle IDA
IDA: 通过直接分析推断
26728129 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC30A10 蛋白结构

Cation_efflux

Cation_efflux: Cation efflux family (11 - 385)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
蛋白主名 其他名称

zinc transporter 10

manganese transporter SLC30A10

SLC30A10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC30A10 Q6XR72 SLC30A3 Homo sapiens Q99726
Crosslink
26728129
种属内
SLC30A10 Q6XR72 SLC30A3 Homo sapiens Q99726
Anti Tag CoIP
26728129
种属内
SLC30A10 Q6XR72 SLC30A2 Homo sapiens Q9BRI3
Confocal
26728129
种属内
SLC30A10 Q6XR72 SLC30A2 Homo sapiens Q9BRI3
Crosslink
26728129
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypermanganesemia With Dystonia 1

Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

HMNDYT1

Hmdpc

Hypermanganesemia With Dystonia Polycythemia And Cirrhosis

Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease

Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia

Familial Manganese-Induced Neurotoxicity

Hmndyt
Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis
Polycythemia

Erythrocythemia

Polycythemia Vera

Polycythaemia Due To High Altitude
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5

Latent Autoimmune Diabetes In Adults

IDDM5

Insulin-Dependent Diabetes Mellitus 5

T1D5

Lada

Type 1.5 Diabetes

Diabetes Mellitus, Insulin-Dependent, Type 5
Pancreatic Cystadenoma

Cystadenoma Of Pancreas
Type 1 Diabetes Mellitus 3

Diabetes Mellitus, Insulin-Dependent, 3

Iddm3

Insulin-Dependent Diabetes Mellitus 3

T1D3
Type 1 Diabetes Mellitus 12

Diabetes Mellitus, Insulin-Dependent, 12

IDDM12

Insulin-Dependent Diabetes Mellitus 12

T1D12

Type 1 Diabetes Mellitus 12, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 12
Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis

KPD

Diabetes Mellitus, Ketosis-Prone, Susceptibility To

Ketosis-Prone Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetic Ketoacidosis Nos

Dka - [Diabetic Ketoacidosis] Nos

Dka - [Diabetic Ketoacidosis] Without Coma

Dka - [Diabetic Ketoacidosis] With Coma
Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications
Type 1 Diabetes Mellitus 15

Diabetes Mellitus, Insulin-Dependent, 15

Iddm15

Insulin-Dependent Diabetes Mellitus 15

T1D15

Insulin-Dependent Diabetes Mellitus-15
Hirata Disease

Insulin Autoimmune Syndrome

Insulin Autoimmune Hypoglycemia
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders
Gastrointestinal System Benign Neoplasm
Autoimmune Disease Of Endocrine System
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13179 SLC30A10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC30A10 MGD MGI:2685058
Rattus norvegicus SLC30A10 RGD RGD:1305098
Bos taurus SLC30A10 VGNC VGNC:34806
Felis catus SLC30A10 VGNC VGNC:65308
Macaca mulatta SLC30A10 VGNC VGNC:106496
Canis familiaris SLC30A10 VGNC VGNC:53131
Others SLC30A10 NCBI
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