KASH5 - KASH domain containing 5 Gene

中文名称：含 KASH 域 5

种属: Homo sapiens

同用名: CCDC155

基因 ID: 147872 | 基因类型: protein coding

关于 KASH5

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,388,249-49,417,990 (from NCBI)

This gene has 15 transcripts (splice variants), 91 orthologues and 30 paralogues. Restricted expression toward testis (RPKM 13.2).

功能概要

预测启用动力蛋白复合物结合活性。预计参与多个过程，包括细胞骨架组织；同源染色体分离；和主轴定位。预计通过同源重组作用于双链断裂修复的上游或内部；卵子发生；和精子发生。预计是膜的组成部分。预计是减数分裂核膜微管束缚复合体的一部分。预测在染色体上有活性；减数分裂纺锤体极；和核外膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable dynein complex binding activity. Predicted to be involved in several processes, including Cytoskeleton organization; homologous chromosome segregation; and spindle localization. Predicted to act upstream of or within double-strand break repair via homologous recombination; oogenesis; and spermatogenesis. Predicted to be integral component of membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in chromosome; meiotic spindle pole; and nuclear outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

KASH5 基因产物(1)

mRNA	Protein	Name
NM_144688.5	NP_653289.3	protein KASH5

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KASH5 蛋白结构

EF-hand_9

KASH_CCD

0
100
200
300
400
500
562 a.a.

蛋白主名

其他名称

protein KASH5

KASH domain-containing protein 5

KASH5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KASH5	Q8N6L0	ADIPOQ	Homo sapiens	A8K660	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	ADIPOQ	Homo sapiens	A8K660	Y2H Array	25416956
种属内	KASH5	Q8N6L0	b2r9h7_human	Homo sapiens	B2R9H7	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	GPR25	Homo sapiens	O00155	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	GPR25	Homo sapiens	O00155	Y2H Array	25416956
种属内	KASH5	Q8N6L0	UPK2	Homo sapiens	O00526	Y2H Array	25416956
种属内	KASH5	Q8N6L0	SLN	Homo sapiens	O00631	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	SLN	Homo sapiens	O00631	Y2H Array	25416956
种属内	KASH5	Q8N6L0	SLN	Homo sapiens	O00631	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	VAMP4	Homo sapiens	O75379-2	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	FTCD	Homo sapiens	O95954	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	VAMP1	Homo sapiens	P23763	Y2H Array	25416956
种属内	KASH5	Q8N6L0	CRABP2	Homo sapiens	P29373	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	CRABP2	Homo sapiens	P29373	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	CLDN8	Homo sapiens	P56748	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	CLDN8	Homo sapiens	P56748	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	CLDN8	Homo sapiens	P56748	Y2H Array	25416956
种属内	KASH5	Q8N6L0	GALNT2	Homo sapiens	Q10471	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	GALNT2	Homo sapiens	Q10471	Y2H Array	25416956
种属内	KASH5	Q8N6L0	GALNT2	Homo sapiens	Q10471	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	BET1	Homo sapiens	Q53XK0	Y2H Array	25416956
种属内	KASH5	Q8N6L0	RTP2	Homo sapiens	Q5QGT7	Y2H Array	25416956
种属内	KASH5	Q8N6L0	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	RIPPLY2	Homo sapiens	Q5TAB7	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	RSRC2	Homo sapiens	Q7L4I2-2	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	TMEM199	Homo sapiens	Q8N511	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TMEM199	Homo sapiens	Q8N511	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	TMEM41A	Homo sapiens	Q96HV5	Y2H Array	25416956
种属内	KASH5	Q8N6L0	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	CIB3	Homo sapiens	Q96Q77	Y2H Array	25416956
种属内	KASH5	Q8N6L0	ABHD1	Homo sapiens	Q96SE0	Y2H Array	25416956
种属内	KASH5	Q8N6L0	NRIP3	Homo sapiens	Q9NQ35	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	NRIP3	Homo sapiens	Q9NQ35	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	NRIP3	Homo sapiens	Q9NQ35	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TMPRSS4	Homo sapiens	Q9NRS4-3	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TMPRSS4	Homo sapiens	Q9NRS4	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TMPRSS4	Homo sapiens	Q9NRS4	Y2H Array	25416956
种属内	KASH5	Q8N6L0	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	LARP1	Homo sapiens	Q6PKG0	Y2H Array	25416956
种属内	KASH5	Q8N6L0	LARP1	Homo sapiens	Q6PKG0	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	LARP1	Homo sapiens	Q6PKG0	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	PIGU	Homo sapiens	Q9H490	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	RNF146	Homo sapiens	Q9NTX7-2	Validated Y2H	27107012
种属内	KASH5	Q8N6L0	RNF146	Homo sapiens	Q9NTX7-2	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	SLC5A4	Homo sapiens	Q9NY91	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	GPATCH4	Homo sapiens	Q5T3I0	Y2H Array	25416956
种属内	KASH5	Q8N6L0	GPATCH4	Homo sapiens	Q5T3I0	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	PPP1R18	Homo sapiens	Q6NYC8	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	OLFM4	Homo sapiens	Q6UX06	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	MS4A1	Homo sapiens	P11836	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	MS4A1	Homo sapiens	P11836	Y2H Array	25416956
种属内	KASH5	Q8N6L0	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	PDGFRA	Homo sapiens	P16234	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	ITM2B	Homo sapiens	Q9Y287	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	ITM2B	Homo sapiens	Q9Y287	Y2H Array	25416956
种属内	KASH5	Q8N6L0	STBD1	Homo sapiens	O95210	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	STBD1	Homo sapiens	O95210	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	SGTA	Homo sapiens	O43765	Validated Y2H	27107012
种属内	KASH5	Q8N6L0	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	BAG5	Homo sapiens	Q9UL15	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	BAG5	Homo sapiens	Q9UL15	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	BAG5	Homo sapiens	Q9UL15	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	CXCL9	Homo sapiens	Q07325	Y2H Array	25416956
种属内	KASH5	Q8N6L0	CDKL3	Homo sapiens	Q8IVW4	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	MFSD5	Homo sapiens	Q6N075	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	MFSD5	Homo sapiens	Q6N075	Y2H Array	25416956
种属内	KASH5	Q8N6L0	DERL1	Homo sapiens	Q9BUN8	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	GOSR2	Homo sapiens	O14653	Y2H Array	25416956
种属内	KASH5	Q8N6L0	EMD	Homo sapiens	P50402	Validated Y2H	27107012
种属内	KASH5	Q8N6L0	PLP2	Homo sapiens	Q04941	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	PLP2	Homo sapiens	Q04941	Y2H Array	25416956
种属内	KASH5	Q8N6L0	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	NSG1	Homo sapiens	P42857	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	NSG1	Homo sapiens	P42857	Y2H Array	25416956
种属内	KASH5	Q8N6L0	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
种属内	KASH5	Q8N6L0	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	BCL2L2	Homo sapiens	Q92843	Validated Y2H	27107012
种属内	KASH5	Q8N6L0	BCL2L2	Homo sapiens	Q92843	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	BCL2L2	Homo sapiens	Q92843	Y2H Array	25416956
种属内	KASH5	Q8N6L0	BCL2L2	Homo sapiens	Q92843	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	FRA10AC1	Homo sapiens	Q70Z53	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	FRA10AC1	Homo sapiens	Q70Z53	Y2H Array	25416956
种属内	KASH5	Q8N6L0	STX5	Homo sapiens	Q13190	Y2H Array	25416956
种属内	KASH5	Q8N6L0	STX5	Homo sapiens	Q13190	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	SENP2	Homo sapiens	Q9HC62	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
种属内	KASH5	Q8N6L0	GABARAPL2	Homo sapiens	P60520	Y2H Array	25416956
种属内	KASH5	Q8N6L0	GABARAPL2	Homo sapiens	P60520	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	RNF146	Homo sapiens	Q9NTX7	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	RNF146	Homo sapiens	Q9NTX7	Y2H Array	25416956
种属内	KASH5	Q8N6L0	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	TMEM11	Homo sapiens	P17152	Validated Y2H	27107012
种属内	KASH5	Q8N6L0	LENG1	Homo sapiens	Q96BZ8	Y2H Array	25416956
种属内	KASH5	Q8N6L0	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	MTX2	Homo sapiens	O75431	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	MTX2	Homo sapiens	O75431	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
种属内	KASH5	Q8N6L0	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	VAMP4	Homo sapiens	O75379	Y2H Array	25416956
种属内	KASH5	Q8N6L0	VAMP4	Homo sapiens	O75379	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	TCF25	Homo sapiens	Q9BQ70	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	SERP2	Homo sapiens	Q8N6R1	Y2H Array	25416956
种属内	KASH5	Q8N6L0	SERP2	Homo sapiens	Q8N6R1	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	MALL	Homo sapiens	Q13021	Y2H Array	25416956
种属内	KASH5	Q8N6L0	ATF7	Homo sapiens	P17544	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	ATF7	Homo sapiens	P17544	Y2H Array	25416956
种属内	KASH5	Q8N6L0	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Array	25416956
种属内	KASH5	Q8N6L0	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	SMCO4	Homo sapiens	Q9NRQ5	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
种属内	KASH5	Q8N6L0	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TSHZ3	Homo sapiens	Q63HK5	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	TSHZ3	Homo sapiens	Q63HK5	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	TSHZ3	Homo sapiens	Q63HK5	Y2H Array	25416956
种属内	KASH5	Q8N6L0	CDC73	Homo sapiens	Q6P1J9	Y2H Array	25416956
种属内	KASH5	Q8N6L0	MMP14	Homo sapiens	P50281	Y2H Prey Pooling	25416956
种属内	KASH5	Q8N6L0	MMP14	Homo sapiens	P50281	Validated Y2H	25416956
种属内	KASH5	Q8N6L0	MMP14	Homo sapiens	P50281	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Genetic Non-Acquired Premature Ovarian Failure

Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy	Congenital Muscular Dystrophy Due To Lmna Mutation
MDCL	L-Cmd
Lmna-Related Congenital Muscular Dystrophy	Muscular Dystrophy, Congenital
Congenital Muscular Dystrophy Lmna-Related	Lmna-Related Cmd
Cmd	Mdc
Muscular Dystrophy Congenital Lmna-Related	Dystrophy, Muscular, Congenital, Lmna-Related
Dystrophy, Muscular, Congenital	Hereditary Muscular Dystrophy
Congenital Hereditary Muscular Dystrophy	Congenital Progressive Muscular Dystrophy
Hereditary Progressive Muscular Dystrophy

Emery-Dreifuss Muscular Dystrophy

Edmd	Emery-Dreifuss Syndrome
Muscular Dystrophy, Emery-Dreifuss	Humeroperoneal Neuromuscular Disease
Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures	Scapuloperoneal Syndrome, X-Linked
Benign Scapuloperoneal Muscular Dystrophy With Early Contractures	Muscular Dystrophy, Emery-Dreifuss Type
Muscular Dystrophy Emery-Dreifuss	Dystrophy, Muscular, Emery-Dreifuss
Emd - [Emery-Dreifuss Muscular Dystrophy]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07072	KASH5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KASH5	VGNC	VGNC:38805
Mus musculus	KASH5	MGD	MGI:2687329
Bos taurus	KASH5	VGNC	VGNC:26860
Rattus norvegicus	KASH5	RGD	RGD:1561972
Macaca mulatta	KASH5	VGNC	VGNC:70871
Felis catus	KASH5	VGNC	VGNC:60471

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