SLN - sarcolipin Gene

中文名称：肌磷脂

种属: Homo sapiens

基因 ID: 6588 | 基因类型: protein coding

关于 SLN

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:107,707,378-107,712,056 (from NCBI)

This gene has 3 transcripts (splice variants) and 10 orthologues. Biased expression in heart (RPKM 82.3), esophagus (RPKM 53.1) and 2 other tissues.

功能概要

肌浆网 CA (2+) -ATP 酶是跨膜蛋白，可催化依赖 ATP 的 CA (2+) 从胞质溶胶转运到肌肉细胞的肌浆网腔中。该基因编码一种小蛋白脂，可调节几种肌浆网 CA (2+) -ATP 酶。跨膜蛋白与 CA (2+) -ATP 酶相互作用，减少肌浆网中 CA (2+) 的积累，而不影响 ATP 水解速率。[RefSeq 提供，2008 年 7 月]

Sarcoplasmic reticulum CA(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of CA(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum CA(2+)-ATPases. The transmembrane protein interacts with CA(2+)-ATPases and reduces the accumulation of CA(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

SLN 基因产物(1)

mRNA	Protein	Name
NM_003063.3	NP_003054.1	sarcolipin

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: 通过直接分析推断	28890335	GOA
involved in regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: 通过直接分析推断	11781085	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in sarcoplasmic reticulum	IDA IDA: 通过直接分析推断	9575189	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLN 蛋白结构

Sarcolipin

0
31 a.a.

蛋白主名

其他名称

sarcolipin

SLN 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLN	O00631	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	SLN	O00631	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	SLN	O00631	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	25416956
Intra	SLN	O00631	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	25416956
Intra	SLN	O00631	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	25416956
Intra	SLN	O00631	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	31515488

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Brody Disease

Brody Myopathy	BROD
Sarcoplasmic Reticulum -Ca2+Atpase Deficiency	Myopathy, Brody

Myasthenic Syndrome, Congenital, 8

Congenital Myasthenic Syndrome 8	CMS8
Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects	Cmsppd
Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects	Congenital Myasthenic Syndrome Due To Agrin Deficiency
Myasthenic Syndrome, Congenital, Due To Agrin Deficiency	Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects
Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects

Atrial Fibrillation

A-Fib	Fibrillation, Atrial
Af - [Atrial Fibrillation]	Rapid Atrial Fibrillation
A Fib - [Atrial Fibrillation]

Sciatic Neuropathy

Lesion Of Sciatic Nerve

Nerve Lesion Sciatic

Sciatic Neuropathy

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Mononeuritis Of Lower Limb

Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p	CMD1P
Cardiomyopathy, Dilated 1p	Cardiomyopathy, Dilated, Type 1p

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-147425	Zerlasiran	Inhibitor	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-113217	Cholesteryl oleate		≥99.0%	否
HY-147425A	Zerlasiran sodium	Inhibitor	95.52%	否
HY-113217S	Cholesteryl oleate-d7		/	否
HY-W013122	Cholesteryl n-butyrate		99.75%	否
HY-113217S1	Cholesteryl oleate-d7-1		/	否
HY-147278	Manusiran	Inhibitor	/	否
HY-147278A	Manusiran sodium	Inhibitor	/	否
HY-164390	6′SLN		/	否
HY-RS13381	SLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SLN	RGD	RGD:1305224
Mus musculus	SLN	MGD	MGI:1913652
Macaca fascicularis	SLN	NCBI	NCBI:102131807
Others	SLN	NCBI

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