1. Gene
  2. TCF25 - transcription factor 25 Gene

TCF25 - transcription factor 25 Gene

中文名称:转录因子 25

种属: Homo sapiens

同用名: Hulp1; NULP1; FKSG26; PRO2620; hKIAA1049

基因 ID: 22980 | 基因类型: protein coding

关于 TCF25

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,873,592-89,911,379 (from NCBI)

This gene has 26 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 33.1), testis (RPKM 28.8) and 25 other tissues.

功能概要

TCF25 是基本螺旋-环-螺旋 (bHLH) 转录因子家族的成员,对胚胎发育很重要 (Steen 和 Lindholm,2008 [PubMed 18068114]) 。[OMIM 提供,2008 年 9 月]

TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

TCF25 基因产物(1)

mRNA Protein Name
NM_014972.3 NP_055787.1 transcription factor 25
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
16574069 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16574069 GOA
involved in regulation of protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
30244831 GOA
involved in rescue of stalled ribosome IDA
IDA: 通过直接分析推断
30244831 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RQC complex IDA
IDA: 通过直接分析推断
30244831 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
16574069 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TCF25 蛋白结构

Tcf25

Tcf25: Transcriptional repressor TCF25 (247 - 588)

  • 0
  • 200
  • 400
  • 600
  • 676 a.a.
蛋白主名 其他名称

transcription factor 25

TCF-25

TCF25 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TCF25 Q9BQ70 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
TCF25 Q9BQ70 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
TCF25 Q9BQ70 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
种属内
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
种属内
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Anti Tag CoIP
33961781
种属内
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Anti Tag CoIP
28514442
种属内
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Anti Tag CoIP
35271311
种属内
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
25416956
种属内
TCF25 Q9BQ70 LRRK2 Homo sapiens Q5S007
Protein Array
24947832
种属内
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H
21516116
种属内
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Array
25416956
种属内
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Pooling
19060904
种属内
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Array
32296183
种属内
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
种属内
TCF25 Q9BQ70 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
TCF25 Q9BQ70 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
TCF25 Q9BQ70 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
TCF25 Q9BQ70 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
种属内
TCF25 Q9BQ70 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
种属内
TCF25 Q9BQ70 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
种属内
TCF25 Q9BQ70 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
种属内
TCF25 Q9BQ70 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
种属内
TCF25 Q9BQ70 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
种属内
TCF25 Q9BQ70 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
种属内
TCF25 Q9BQ70 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Vulvovaginitis

Vulvo-Vaginitis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TCF25 VGNC VGNC:66025
Mus musculus TCF25 MGD MGI:1914105
Macaca mulatta TCF25 VGNC VGNC:99607
Bos taurus TCF25 VGNC VGNC:35692
Canis familiaris TCF25 VGNC VGNC:47196
Rattus norvegicus TCF25 RGD RGD:1309054