APPBP2 - amyloid beta precursor protein binding protein 2 Gene

中文名称：淀粉样蛋白前体蛋白结合蛋白 2

种属: Homo sapiens

同用名: PAT1; APP-BP2; HS.84084

基因 ID: 10513 | 基因类型: protein coding

关于 APPBP2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:60,443,158-60,526,242 (from NCBI)

This gene has 6 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 16.4), brain (RPKM 11.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质与微管相互作用，并在功能上与 β-淀粉样蛋白前体蛋白转运和/或加工相关。 β-淀粉样蛋白前体蛋白是一种具有信号转导特性的细胞表面蛋白，被认为在阿尔茨海默病的发病机制中发挥作用。编码的蛋白质可能参与调节细胞死亡。已发现该基因在乳腺癌中高度表达。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

APPBP2 基因产物(2)

mRNA	Protein	Name
NM_001282476.2	NP_001269405.1	amyloid protein-binding protein 2 isoform 2
NM_006380.5	NP_006371.2	amyloid protein-binding protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	26138980	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within intracellular transport	IDA IDA: 通过直接分析推断	9843960	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	26138980	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul2-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	26138980	GOA
located in cytoplasmic vesicle membrane	IDA IDA: 通过直接分析推断	9843960	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APPBP2 蛋白结构

TPR_12

TPR_10

0
100
200
300
400
500
585 a.a.

蛋白主名

其他名称

amyloid protein-binding protein 2

amyloid beta precursor protein (cytoplasmic tail) binding protein 2

APPBP2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	APPBP2	Q92624	HEL-S-72	Homo sapiens	B4DJ51	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ST8SIA5	Homo sapiens	O15466	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ST8SIA5	Homo sapiens	O15466	Validated Y2H	25416956
种属内	APPBP2	Q92624	LUZP4	Homo sapiens	Q9P127	Validated Y2H	32296183
种属内	APPBP2	Q92624	LUZP4	Homo sapiens	Q9P127	Y2H Array	25416956
种属内	APPBP2	Q92624	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	FXYD7	Homo sapiens	P58549	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	FXYD7	Homo sapiens	P58549	Validated Y2H	25416956
种属内	APPBP2	Q92624	SELENOV	Homo sapiens	P59797	Validated Y2H	25416956
种属内	APPBP2	Q92624	SELENOV	Homo sapiens	P59797	Y2H Array	25416956
种属内	APPBP2	Q92624	C6orf226	Homo sapiens	Q5I0X4	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	C6orf226	Homo sapiens	Q5I0X4	Y2H Array	25416956
种属内	APPBP2	Q92624	ARMCX5	Homo sapiens	Q6P1M9	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ANKRD10	Homo sapiens	Q8IUW1	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ANKRD10	Homo sapiens	Q8IUW1	Validated Y2H	25416956
种属内	APPBP2	Q92624	GCSAM	Homo sapiens	Q8N6F7	Validated Y2H	25416956
种属内	APPBP2	Q92624	GCSAM	Homo sapiens	Q8N6F7	Y2H Array	25416956
种属内	APPBP2	Q92624	TAF11	Homo sapiens	Q15544	Validated Y2H	25416956
种属内	APPBP2	Q92624	TAF11	Homo sapiens	Q15544	Y2H Array	25416956
种属内	APPBP2	Q92624	TAFA4	Homo sapiens	Q96LR4	Validated Y2H	25416956
种属内	APPBP2	Q92624	TAFA4	Homo sapiens	Q96LR4	Y2H Array	25416956
种属内	APPBP2	Q92624	PCTK1	Homo sapiens	Q9BRL4	Y2H Array	25416956
种属内	APPBP2	Q92624	C16orf35	Homo sapiens	Q9BTE2	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ANKRD10	Homo sapiens	Q9NXR5	Validated Y2H	25416956
种属内	APPBP2	Q92624	AHCY	Homo sapiens	P23526	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	UGGT2	Homo sapiens	Q9NYU1	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	UGGT2	Homo sapiens	Q9NYU1	Y2H Array	25416956
种属内	APPBP2	Q92624	UGGT2	Homo sapiens	Q9NYU1	Validated Y2H	25416956
种属内	APPBP2	Q92624	SLC7A10	Homo sapiens	Q9NS82	Validated Y2H	32296183
种属内	APPBP2	Q92624	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
种属内	APPBP2	Q92624	SNX5	Homo sapiens	Q9Y5X3-2	Validated Y2H	32296183
种属内	APPBP2	Q92624	MAN2B2	Homo sapiens	Q9Y2E5	Validated Y2H	32296183
种属内	APPBP2	Q92624	SYNRG	Homo sapiens	Q9UMZ2-8	Validated Y2H	32296183
种属内	APPBP2	Q92624	BIN2	Homo sapiens	Q9UBW5	Validated Y2H	32296183
种属内	APPBP2	Q92624	RNF34	Homo sapiens	Q969K3	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	RNF34	Homo sapiens	Q969K3	Y2H Array	25416956
种属内	APPBP2	Q92624	UBE2R2	Homo sapiens	Q712K3	Validated Y2H	25416956
种属内	APPBP2	Q92624	RNF128	Homo sapiens	Q8TEB7	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	FSTL1	Homo sapiens	Q12841	Y2H Array	19060904
种属内	APPBP2	Q92624	FSTL1	Homo sapiens	Q12841	Y2H Pooling	19060904
种属内	APPBP2	Q92624	FSTL1	Homo sapiens	Q12841	Y2H Array	25416956
种属内	APPBP2	Q92624	WFIKKN1	Homo sapiens	Q96NZ8	Validated Y2H	32296183
种属内	APPBP2	Q92624	LANCL2	Homo sapiens	Q9NS86	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	LANCL2	Homo sapiens	Q9NS86	Validated Y2H	32296183
种属内	APPBP2	Q92624	LANCL2	Homo sapiens	Q9NS86	Y2H Array	25416956
种属内	APPBP2	Q92624	CTC1	Homo sapiens	Q2NKJ3	Validated Y2H	25416956
种属内	APPBP2	Q92624	CTC1	Homo sapiens	Q2NKJ3	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ERO1A	Homo sapiens	Q96HE7	Y2H Array	25416956
种属内	APPBP2	Q92624	ERO1A	Homo sapiens	Q96HE7	Validated Y2H	25416956
种属内	APPBP2	Q92624	PRKACB	Homo sapiens	P22694	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	PRKACB	Homo sapiens	P22694	Y2H Array	25416956
种属内	APPBP2	Q92624	LONRF3	Homo sapiens	Q496Y0	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	LONRF3	Homo sapiens	Q496Y0	Y2H Array	25416956
种属内	APPBP2	Q92624	CCNL1	Homo sapiens	Q9UK58	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	CCNL1	Homo sapiens	Q9UK58	Validated Y2H	25416956
种属内	APPBP2	Q92624	C1orf50	Homo sapiens	Q9BV19	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	C1orf50	Homo sapiens	Q9BV19	Validated Y2H	32296183
种属内	APPBP2	Q92624	SLC25A23	Homo sapiens	Q9BV35	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	SLC25A23	Homo sapiens	Q9BV35	Validated Y2H	25416956
种属内	APPBP2	Q92624	WAS	Homo sapiens	P42768	Y2H Array	25416956
种属内	APPBP2	Q92624	WAS	Homo sapiens	P42768	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	25416956
种属内	APPBP2	Q92624	LUC7L2	Homo sapiens	Q9Y383	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
种属内	APPBP2	Q92624	GSTP1	Homo sapiens	P09211	Y2H Array	25416956
种属内	APPBP2	Q92624	GSTP1	Homo sapiens	P09211	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	DHRS2	Homo sapiens	Q13268	Validated Y2H	25416956
种属内	APPBP2	Q92624	HSPA4	Homo sapiens	P34932	Validated Y2H	25416956
种属内	APPBP2	Q92624	HSPA4	Homo sapiens	P34932	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	NFYA	Homo sapiens	P23511	Y2H Pooling	19060904
种属内	APPBP2	Q92624	NFYA	Homo sapiens	P23511	Y2H Array	19060904
种属内	APPBP2	Q92624	AK3	Homo sapiens	Q9UIJ7	Validated Y2H	32296183
种属内	APPBP2	Q92624	AK3	Homo sapiens	Q9UIJ7	Y2H Array	25416956
种属内	APPBP2	Q92624	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
种属内	APPBP2	Q92624	RAB7B	Homo sapiens	Q96AH8	Validated Y2H	32296183
种属内	APPBP2	Q92624	DCD	Homo sapiens	P81605	Y2H Array	25416956
种属内	APPBP2	Q92624	DCD	Homo sapiens	P81605	Validated Y2H	25416956
种属内	APPBP2	Q92624	ZNF747	Homo sapiens	Q9BV97	Validated Y2H	25416956
种属内	APPBP2	Q92624	ZNF747	Homo sapiens	Q9BV97	Y2H Array	25416956
种属内	APPBP2	Q92624	HIPK4	Homo sapiens	Q8NE63	Validated Y2H	25416956
种属内	APPBP2	Q92624	HIPK4	Homo sapiens	Q8NE63	Y2H Array	25416956
种属内	APPBP2	Q92624	SNX5	Homo sapiens	Q9Y5X3	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	TBL3	Homo sapiens	Q12788	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	TBL3	Homo sapiens	Q12788	Y2H Pooling	16189514
种属内	APPBP2	Q92624	PPP1R8	Homo sapiens	Q12972	Validated Y2H	25416956
种属内	APPBP2	Q92624	MCOLN1	Homo sapiens	Q9GZU1	Validated Y2H	32296183
种属内	APPBP2	Q92624	CORO2B	Homo sapiens	Q9UQ03	Validated Y2H	32296183
种属内	APPBP2	Q92624	CORO2B	Homo sapiens	Q9UQ03	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	SYNRG	Homo sapiens	Q9UMZ2	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	MGAT4B	Homo sapiens	Q9UQ53	Validated Y2H	32296183
种属内	APPBP2	Q92624	CDK16	Homo sapiens	Q00536	Validated Y2H	25416956
种属内	APPBP2	Q92624	CDK16	Homo sapiens	Q00536	Y2H Array	25416956
种属内	APPBP2	Q92624	CDK16	Homo sapiens	Q00536	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	ZC3H10	Homo sapiens	Q96K80	Y2H Array	25416956
种属内	APPBP2	Q92624	ZC3H10	Homo sapiens	Q96K80	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Y2H Array	19060904
种属内	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Y2H Pooling	19060904
种属内	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Y2H Pooling	16189514
种属内	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Validated Y2H	32296183
种属内	APPBP2	Q92624	TCF25	Homo sapiens	Q9BQ70	Validated Y2H	25416956
种属内	APPBP2	Q92624	WDR24	Homo sapiens	Q96S15	Y2H Pooling	16189514
种属内	APPBP2	Q92624	WDR24	Homo sapiens	Q96S15	Validated Y2H	25416956
种属内	APPBP2	Q92624	RRS1	Homo sapiens	Q15050	Y2H Pooling	16189514
种属内	APPBP2	Q92624	DPEP1	Homo sapiens	P16444	Y2H Array	25416956
种属内	APPBP2	Q92624	SLC22A6	Homo sapiens	Q4U2R8	Y2H Array	19060904
种属内	APPBP2	Q92624	SLC22A6	Homo sapiens	Q4U2R8	Y2H Pooling	19060904
种属内	APPBP2	Q92624	SELI	Homo sapiens	Q8WU57	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	SELI	Homo sapiens	Q8WU57	Y2H Array	25416956
种属内	APPBP2	Q92624	SYT11	Homo sapiens	Q9BT88	Y2H Pooling	19060904
种属内	APPBP2	Q92624	SYT11	Homo sapiens	Q9BT88	Y2H Pooling	16189514
种属内	APPBP2	Q92624	SYT11	Homo sapiens	Q9BT88	Y2H Array	19060904
种属内	APPBP2	Q92624	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183
种属内	APPBP2	Q92624	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
种属内	APPBP2	Q92624	KLHL35	Homo sapiens	Q6PF15	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	KLF11	Homo sapiens	O14901	Y2H Prey Pooling	25416956
种属内	APPBP2	Q92624	KLF11	Homo sapiens	O14901	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ovarian Clear Cell Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00866	APPBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	APPBP2	VGNC	VGNC:69991
Canis familiaris	APPBP2	VGNC	VGNC:38011
Bos taurus	APPBP2	VGNC	VGNC:26039
Felis catus	APPBP2	VGNC	VGNC:67891
Rattus norvegicus	APPBP2	RGD	RGD:1306488
Mus musculus	APPBP2	MGD	MGI:1914134

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