1. Gene
  2. WDR24 - WD repeat domain 24 Gene

WDR24 - WD repeat domain 24 Gene

中文名称:WD 重复域 24

种属: Homo sapiens

同用名: JFP7; C16orf21

基因 ID: 84219 | 基因类型: protein coding

关于 WDR24

This gene has 4 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 5.5), spleen (RPKM 3.4) and 25 other tissues.

功能概要

参与细胞对氨基酸饥饿的反应; TOR 信号的正调控;和自噬的调节。位于胞质溶胶和溶酶体膜中。 GATOR2 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of Autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

WDR24 基因产物(1)

mRNA Protein Name
NM_032259.4 NP_115635.1 GATOR complex protein WDR24
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
36528027 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid starvation IMP
IMP: 通过突变表型推断
23723238 GOA
involved in cellular response to nutrient levels IDA
IDA: 通过直接分析推断
35831510 GOA
involved in positive regulation of TOR signaling IMP
IMP: 通过突变表型推断
27166823 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
35831510 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
36577058 GOA
involved in protein K6-linked ubiquitination IDA
IDA: 通过直接分析推断
36528027 GOA
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
27166823 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of GATOR2 complex IDA
IDA: 通过直接分析推断
35831510 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
28199306 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WDR24 蛋白结构

WD40

WD40: WD domain, G-beta repeat (176 - 211)

WD40

WD40: WD domain, G-beta repeat (329 - 366)

WD40

WD40: WD domain, G-beta repeat (422 - 453)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 920 a.a.
蛋白主名 其他名称

GATOR complex protein WDR24

WD repeat-containing protein 24

WDR24 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra WDR24 Q96S15 SZT2 Homo sapiens Q5T011
Anti Bait CoIP
28199315
Intra WDR24 Q96S15 SZT2 Homo sapiens Q5T011
Crosslink
28199315
Intra WDR24 Q96S15 SESN3 Homo sapiens P58005
Anti Tag CoIP
26449471
Intra WDR24 Q96S15 SESN3 Homo sapiens P58005
Anti Tag CoIP
25263562
Intra WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
25263562
Intra WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
28199315
Intra WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Anti Bait CoIP
28199315
Intra WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
GMS
28199315
Intra WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Crosslink
28199315
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
25263562
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
25263562
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
26449471
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
28199315
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
26972053
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
28199315
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26972053
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26586190
Intra WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26449471
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
26449471
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
26586190
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Bait CoIP
25263562
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
28199315
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
25263562
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Bait CoIP
26449471
Intra WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Bait CoIP
26972053
Intra WDR24 Q96S15 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra WDR24 Q96S15 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Mus musculus WDR24 MGD MGI:2446285
Canis familiaris WDR24 VGNC VGNC:48356
Rattus norvegicus WDR24 RGD RGD:1304803
Bos taurus WDR24 VGNC VGNC:36887
Macaca mulatta WDR24 VGNC VGNC:79289
Felis catus WDR24 VGNC VGNC:67021