2. Gene
  3. SESN2 - sestrin 2 Gene

SESN2 - sestrin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：sestrin 2

种属: Homo sapiens

同用名: HI95; SES2; SEST2

基因 ID: 83667 | 基因类型: protein coding

关于 SESN2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,259,518-28,282,491 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 189 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), kidney (RPKM 10.3) and 24 other tissues.

功能概要

该基因编码 PA26 相关蛋白的 sestrin 家族成员。编码的蛋白质可能在细胞生长和存活的调节中发挥作用。这种蛋白质可能参与细胞对不同应激条件的反应。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

SESN2 基因产物(1)

mRNA Protein Name
NM_031459.5 NP_113647.1 sestrin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-leucine binding IDA
IDA: 通过直接分析推断
26449471 GOA
enables peroxidase activity IDA
IDA: 通过直接分析推断
26612684 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15105503 GOA
enables protein sequestering activity IDA
IDA: 通过直接分析推断
26586190 GOA
NOT enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
26449471 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
25263562 GOA
NOT enables sulfiredoxin activity IDA
IDA: 通过直接分析推断
19113821 GOA
enables sulfiredoxin activity IDA
IDA: 通过直接分析推断
15105503 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
18692468 GOA
NOT involved in cellular oxidant detoxification IDA
IDA: 通过直接分析推断
19113821 GOA
involved in cellular oxidant detoxification IDA
IDA: 通过直接分析推断
26612684 GOA
involved in cellular oxidant detoxification IMP
IMP: 通过突变表型推断
15105503 GOA
involved in cellular response to L-leucine IDA
IDA: 通过直接分析推断
26449471 GOA
involved in cellular response to L-leucine IMP
IMP: 通过突变表型推断
26586190 GOA
involved in cellular response to amino acid starvation IMP
IMP: 通过突变表型推断
25263562 GOA
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
25457612 GOA
involved in cellular response to glucose starvation IMP
IMP: 通过突变表型推断
25263562 GOA
involved in cellular response to leucine starvation IDA
IDA: 通过直接分析推断
35114100 GOA
involved in cellular response to leucine starvation IMP
IMP: 通过突变表型推断
26449471 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
35114100 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
18692468 GOA
involved in negative regulation of translation in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
24947615 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
26449471 GOA
involved in positive regulation of macroautophagy IMP
IMP: 通过突变表型推断
23274085 GOA
involved in positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
23274085 GOA
involved in reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
26612684 GOA
involved in reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
15105503 GOA
involved in regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
36528027 GOA
involved in regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
25040165 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Atg1/ULK1 kinase complex IPI
IPI: 通过物理相互作用推断
25040165 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15105503 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
15105503 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SESN2 蛋白结构

PA26

PA26: PA26 p53-induced protein (sestrin) (42 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
蛋白主名 其他名称

sestrin-2

hypoxia induced gene 95

SESN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross SESN2 P58004 Rbx1 Mus musculus P62878
Anti Tag CoIP
23274085
Intra SESN2 P58004 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
25263562
Intra SESN2 P58004 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26586190
Intra SESN2 P58004 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
28199315
Intra SESN2 P58004 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
23274085
Intra SESN2 P58004 SQSTM1 Homo sapiens Q13501
Pull Down
25040165
Intra SESN2 P58004 SQSTM1 Homo sapiens Q13501
Anti Bait CoIP
25040165
Intra SESN2 P58004 RBX1 Homo sapiens P62877
Anti Tag CoIP
23274085
Intra SESN2 P58004 RBX1 Homo sapiens P62877
Anti Tag CoIP
29294217
Intra SESN2 P58004 WDR24 Homo sapiens Q96S15
Anti Tag CoIP
26586190
Intra SESN2 P58004 WDR24 Homo sapiens Q96S15
Anti Bait CoIP
28199315
Intra SESN2 P58004 WDR24 Homo sapiens Q96S15
Anti Tag CoIP
25263562
Intra SESN2 P58004 KEAP1 Homo sapiens Q14145
Anti Tag CoIP
23274085
Cross SESN2 P58004 Ulk1 Mus musculus O70405
Anti Tag CoIP
25040165
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pulmonary Emphysema
Nodular Ganglioneuroblastoma

Ganglioneuroblastoma, Nodular
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12735 SESN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SESN2 VGNC VGNC:77286
Bos taurus SESN2 VGNC VGNC:34489
Rattus norvegicus SESN2 RGD RGD:1566319
Canis familiaris SESN2 VGNC VGNC:46048
Felis catus SESN2 VGNC VGNC:65035
Mus musculus SESN2 MGD MGI:2651874
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