2. Gene
  3. SLC25A23 - solute carrier family 25 member 23 Gene

SLC25A23 - solute carrier family 25 member 23 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 25 成员 23

种属: Homo sapiens

同用名: APC2; MCSC2; SCAMC3; SCaMC-3

基因 ID: 79085 | 基因类型: protein coding

关于 SLC25A23

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,436,081-6,459,792 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 49 paralogues. Ubiquitous expression in brain (RPKM 40.2), thyroid (RPKM 28.7) and 23 other tissues.

功能概要

预测可启用 ATP 跨膜转运蛋白活性。参与钙输入线粒体；线粒体钙离子浓度的正向调节；和调节细胞高渗盐度反应。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP transmembrane transporter activity. Involved in calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SLC25A23 基因产物(1)

mRNA Protein Name
NM_024103.3 NP_077008.2 calcium-binding mitochondrial carrier protein SCaMC-3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP:phosphate antiporter activity IDA
IDA: 通过直接分析推断
15123600 GOA
enables ATP:phosphate antiporter activity IDA
IDA: 通过直接分析推断
15123600 GOA
enables adenine nucleotide transmembrane transporter activity IDA
IDA: 通过直接分析推断
15123600 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24430870 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenine nucleotide transport IDA
IDA: 通过直接分析推断
15123600 GOA
involved in calcium import into the mitochondrion IMP
IMP: 通过突变表型推断
24430870 GOA
involved in mitochondrial ATP transmembrane transport IDA
IDA: 通过直接分析推断
15123600 GOA
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
24430870 GOA
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: 通过突变表型推断
26975899 GOA
involved in regulation of cellular hyperosmotic salinity response IMP
IMP: 通过突变表型推断
26975899 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
15054102 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A23 蛋白结构

EF-hand_6

EF-hand_6: EF-hand domain (16 - 41)

EF-hand_7

EF-hand_7: EF-hand domain pair (83 - 139)

Mito_carr

Mito_carr: Mitochondrial carrier protein (185 - 271)

Mito_carr

Mito_carr: Mitochondrial carrier protein (277 - 364)

Mito_carr

Mito_carr: Mitochondrial carrier protein (375 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
蛋白主名 其他名称

calcium-binding mitochondrial carrier protein SCaMC-3

mitochondrial ATP-Mg/Pi carrier protein 2

SLC25A23 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC25A23 Q9BV35 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11

Ichthyosis With Hypotrichosis, Autosomal Recessive

Arih

Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis

Autosomal Recessive Ichthyosis With Hypotrichosis

ARCI11

Ifah

Hypotrichosis-Congenital Ichthyosis Syndrome

Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome

Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome

Ichthyosis-Hypotrichosis Syndrome

Ifah Syndrome

Ihs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13104 SLC25A23 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC25A23 RGD RGD:1588586
Macaca mulatta SLC25A23 VGNC VGNC:107116
Mus musculus SLC25A23 MGD MGI:1914222
Bos taurus SLC25A23 VGNC VGNC:55309
Felis catus SLC25A23 VGNC VGNC:80716
Canis familiaris SLC25A23 VGNC VGNC:106610
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