2. Gene
  3. LONRF3 - LON peptidase N-terminal domain and ring finger 3 Gene

LONRF3 - LON peptidase N-terminal domain and ring finger 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LON 肽酶 N 末端结构域和无名指 3

种属: Homo sapiens

同用名: RNF127

基因 ID: 79836 | 基因类型: protein coding

关于 LONRF3

This gene has 6 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 3.2), liver (RPKM 3.1) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个环指结构域，该结构域存在于多种功能不同的蛋白质中，已知参与蛋白质-蛋白质和蛋白质-DNA 相互作用。已经提出了多个选择性剪接的转录本变体，但它们的全长性质尚不清楚。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

LONRF3 基因产物(3)

mRNA Protein Name
NM_001031855.3 NP_001027026.1 LON peptidase N-terminal domain and RING finger protein 3 isoform 1
NM_001289109.1 NP_001276038.1 LON peptidase N-terminal domain and RING finger protein 3 isoform 3
NM_024778.5 NP_079054.3 LON peptidase N-terminal domain and RING finger protein 3 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20195357 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LONRF3 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (158 - 195)

TPR_11

TPR_11: TPR repeat (242 - 308)

TPR_2

TPR_2: Tetratricopeptide repeat (312 - 344)

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (467 - 504)

LON_substr_bdg

LON_substr_bdg: ATP-dependent protease La (LON) substrate-binding domain (555 - 746)

  • 0
  • 200
  • 400
  • 600
  • 759 a.a.
蛋白主名 其他名称

LON peptidase N-terminal domain and RING finger protein 3

ring finger protein 127

LONRF3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LONRF3 Q496Y0 DES Homo sapiens P17661
Y2H Array
32296183
种属内
LONRF3 Q496Y0 DES Homo sapiens P17661
Y2H Prey Pooling
32296183
种属内
LONRF3 Q496Y0 CTAG1A Homo sapiens P78358
Y2H Array
32296183
种属内
LONRF3 Q496Y0 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
种属内
LONRF3 Q496Y0 PHB1 Homo sapiens P35232
TAP
20195357
种属内
LONRF3 Q496Y0 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
种属内
LONRF3 Q496Y0 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
种属内
LONRF3 Q496Y0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
LONRF3 Q496Y0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
LONRF3 Q496Y0 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cleft Palate With Or Without Ankyloglossia, X-Linked

Cleft Palate With Ankyloglossia

CPX

X-Linked Cleft Palate And Ankyloglossia

X-Linked Cleft Palate With Or Without Ankyloglossia

X-Linked Cleft Palate

X-Linked Cleft Palate With Ankyloglossia

Cleft Palate, With/Without Ankyloglossia, X-Linked
Ankyloglossia With Or Without Tooth Anomalies

Ankyloglossia

ANKG

'Tongue-Tie'

Tongue-Tie

Tongue Tie

Aberrant Insertion Of Labial Frenulum

Aberrant Insertion Of Frenum Of Tongue

Short Frenulum Linguae

Short Frenulum Of Tongue
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07737 LONRF3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LONRF3 VGNC VGNC:74327
Canis familiaris LONRF3 VGNC VGNC:42736
Bos taurus LONRF3 VGNC VGNC:30950
Rattus norvegicus LONRF3 RGD RGD:1565451
Mus musculus LONRF3 MGD MGI:1921615
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z