GCSAM - germinal center associated signaling and motility Gene

中文名称：生发中心相关信号和运动

种属: Homo sapiens

同用名: HGAL; GCAT2; GCET2

基因 ID: 257144 | 基因类型: protein coding

关于 GCSAM

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,120,839-112,133,248 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 77 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 14.9), skin (RPKM 5.8) and 13 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质可能在信号转导通路中起作用，其表达在生发细胞淋巴瘤中升高。它包含一个推定的 PDZ 相互作用结构域、一个基于免疫受体酪氨酸的激活基序 (ITAM) 和两个推定的 SH2 结合位点。在 B 细胞中，它的表达是由白细胞介素 4 特异性诱导的。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GCSAM 基因产物(3)

mRNA	Protein	Name
NM_001190259.2	NP_001177188.1	germinal center-associated signaling and motility protein isoform 3
NM_001190260.2	NP_001177189.1	germinal center-associated signaling and motility protein isoform 4
NM_152785.5	NP_689998.1	germinal center-associated signaling and motility protein isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IPI IPI: 通过物理相互作用推断	17823310	GOA
enables myosin II binding	IPI IPI: 通过物理相互作用推断	17823310	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20844236	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	23299888	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of lymphocyte migration	IMP IMP: 通过突变表型推断	17823310	GOA
involved in regulation of B cell receptor signaling pathway	IMP IMP: 通过突变表型推断	23299888	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

germinal center-associated signaling and motility protein

germinal center B-cell-expressed transcript 2 protein

GCSAM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GCSAM	Q8N6F7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属内	GCSAM	Q8N6F7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	GCSAM	Q8N6F7	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
种属内	GCSAM	Q8N6F7	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
种属内	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
种属内	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
种属内	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
种属内	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

GCSAM 抗体

目录号	产品名	应用	反应物种
HY-P81387	GCET2 Antibody (YA1132)	IHC-P	Human

关联疾病

疾病名称

别名

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis	Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Alzheimer Disease 17

AD17	Alzheimer'S Disease 17
Alzheimer Disease 17, Late-Onset	Alzheimer Disease 17, Late Onset

Retroperitoneal Lymphoma

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05343	GCSAM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GCSAM	VGNC	VGNC:29293
Mus musculus	GCSAM	MGD	MGI:102969
Felis catus	GCSAM	VGNC	VGNC:102727
Rattus norvegicus	GCSAM	RGD	RGD:1591321
Macaca mulatta	GCSAM	VGNC	VGNC:72752
Canis familiaris	GCSAM	VGNC	VGNC:41152

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