RNF34 - ring finger protein 34 Gene

中文名称：无名指蛋白 34

种属: Homo sapiens

同用名: RFI; RIF; RIFF; hRFI; CARP1; CARP-1

关于 RNF34

功能概要

由该基因编码的蛋白质包含一个 RINF 指，这是一种已知参与蛋白质-蛋白质和蛋白质-DNA 相互作用的基序。该蛋白与 DNAJA3/hTid-1 相互作用，后者是一种据报道可作为细胞凋亡调节剂发挥作用的 DnaJ 蛋白。该基因在 Hela 细胞中的过度表达显示赋予对 TNF-α 诱导的细胞凋亡的抗性，表明该蛋白质的抗细胞凋亡功能。在诱导细胞凋亡过程中，该蛋白可被 Caspase-3 切割。该蛋白质还靶向 p53 和磷酸化 p53 进行降解。选择性剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of Apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced Apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by Caspase-3 during the induction of Apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]