CCNL1 - cyclin L1 Gene

中文名称：细胞周期蛋白 L1

种属: Homo sapiens

同用名: ANIA6A; BM-001; PRO1073; ania-6a

基因 ID: 57018 | 基因类型: protein coding

关于 CCNL1

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:157,143,121-157,160,147 (from NCBI)

This gene has 26 transcripts (splice variants), 221 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 197.4), appendix (RPKM 28.6) and 17 other tissues.

功能概要

预测可启用细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶调节剂活性。预计参与 RNA 聚合酶 II 的转录调控。位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CCNL1 基因产物(2)

mRNA	Protein	Name
NM_001308185.2	NP_001295114.1	cyclin-L1 isoform 2
NM_020307.4	NP_064703.1	cyclin-L1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23455924	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of RNA splicing	IDA IDA: 通过直接分析推断	12501247	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: 通过物理相互作用推断	18216018	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17494991	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNL1 蛋白结构

Cyclin_N

0
100
200
300
400
526 a.a.

蛋白主名

其他名称

cyclin-L1

cyclin L ania-6a

CCNL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CCNL1	Q9UK58	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	CCNL1	Q9UK58	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	SREK1IP1	Homo sapiens	Q8N9Q2	Y2H Array	32296183
Intra	CCNL1	Q9UK58	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	CCNL1	Q9UK58	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	CCNL1	Q9UK58	CASP8	Homo sapiens	Q6NVI2	Y2H Array	32296183
Intra	CCNL1	Q9UK58	CASP8	Homo sapiens	Q6NVI2	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Array	32296183
Intra	CCNL1	Q9UK58	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	CCNL1	Q9UK58	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	CCNL1	Q9UK58	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	CCNL1	Q9UK58	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956
Intra	CCNL1	Q9UK58	RSRP1	Homo sapiens	Q9BUV0	Y2H Array	32296183
Intra	CCNL1	Q9UK58	RSRP1	Homo sapiens	Q9BUV0	Y2H Prey Pooling	32296183
Intra	CCNL1	Q9UK58	SAP30BP	Homo sapiens	Q9UHR5	Anti Tag CoIP	33961781
Intra	CCNL1	Q9UK58	JMJD6	Homo sapiens	Q6NYC1	Y2H	23455924

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Tarsal Tunnel Syndrome

Neuropathy Of The Posterior Tibial Nerve And Its Branches	Posterior Tibial Nerve Neuralgia
Compression Of Posterior Tibial Nerve In Tarsal Tunnel

Tibial Neuropathy

Posterior Tibial Neuropathy

Alzheimer Disease 6

Ad6	Alzheimer Disease 6, Late-Onset
Alzheimer'S Disease 6	Alzheimer Disease 6, Late Onset

Plantar Fasciitis

Fasciitis, Plantar

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02136	CCNL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CCNL1	VGNC	VGNC:26975
Mus musculus	CCNL1	MGD	MGI:1922664
Macaca mulatta	CCNL1	VGNC	VGNC:70830
Felis catus	CCNL1	VGNC	VGNC:60566
Rattus norvegicus	CCNL1	RGD	RGD:620864

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