2. Gene
  3. PRDM6 - PR/SET domain 6 Gene

PRDM6 - PR/SET domain 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PR/SET 域 6

种属: Homo sapiens

同用名: PDA3; KMT8C; PRISM

基因 ID: 93166 | 基因类型: protein coding

关于 PRDM6

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:123,089,241-123,194,266 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 36 paralogues and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 2.3), placenta (RPKM 2.0) and 16 other tissues.

功能概要

该基因编码的蛋白质是转录抑制因子，是 PRDM 家族的成员。家族成员包含一个 PR 结构域和多个锌指结构域。编码的蛋白质参与血管平滑肌细胞 (VSMC) 收缩蛋白的调节。该基因的突变导致动脉导管未闭 3 (PDA3) 。[RefSeq 提供，2017 年 4 月]

The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]

PRDM6 基因产物(1)

mRNA Protein Name
NM_001136239.4 NP_001129711.1 putative histone-lysine N-methyltransferase PRDM6
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16537907 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRDM6 蛋白结构

SET

SET: SET domain (260 - 365)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (473 - 492)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (501 - 523)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (544 - 567)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
蛋白主名 其他名称

putative histone-lysine N-methyltransferase PRDM6

PR domain 6

PRDM6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRDM6 Q9NQX0 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra PRDM6 Q9NQX0 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra PRDM6 Q9NQX0 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra PRDM6 Q9NQX0 FOXD4L1 Homo sapiens Q9NU39
Validated Y2H
32296183
Intra PRDM6 Q9NQX0 TCAF1 Homo sapiens Q9Y4C2-2
Validated Y2H
32296183
Intra PRDM6 Q9NQX0 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra PRDM6 Q9NQX0 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra PRDM6 Q9NQX0 SAMD4A Homo sapiens Q9UPU9-3
Validated Y2H
32296183
Intra PRDM6 Q9NQX0 IL16 Homo sapiens Q14005-2
Y2H Array
32296183
Intra PRDM6 Q9NQX0 FTO Homo sapiens Q9C0B1-2
Y2H Array
32296183
Intra PRDM6 Q9NQX0 FTO Homo sapiens Q9C0B1-2
Y2H Prey Pooling
32296183
Intra PRDM6 Q9NQX0 AHCYL1 Homo sapiens O43865
Y2H Array
32296183
Intra PRDM6 Q9NQX0 AHCYL1 Homo sapiens O43865
Y2H Prey Pooling
32296183
Intra PRDM6 Q9NQX0 CCNL1 Homo sapiens Q9UK58
Validated Y2H
32296183
Intra PRDM6 Q9NQX0 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra PRDM6 Q9NQX0 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra PRDM6 Q9NQX0 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Patent Ductus Arteriosus 3

PDA3
Familial Patent Arterial Duct
Patent Ductus Arteriosus 1

Patent Ductus Arteriosus

PDA1

Pda

Ductus Arteriosus, Patent

Patent Ductus Arteriosus, Susceptibility To

Patent Ductus Botalli

Patency Of The Ductus Arteriosus

Patent Ductus Arteriosus Familial

Ductus Arteriosus Patent

Patent Ductus Arteriosus - Persisting Type
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11070 PRDM6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PRDM6 VGNC VGNC:44950
Rattus norvegicus PRDM6 RGD RGD:1559594
Felis catus PRDM6 VGNC VGNC:69036
Mus musculus PRDM6 MGD MGI:2684938
Bos taurus PRDM6 VGNC VGNC:33298
Macaca mulatta PRDM6 VGNC VGNC:110444
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