1. Gene
  2. AHCYL1 - adenosylhomocysteinase like 1 Gene

AHCYL1 - adenosylhomocysteinase like 1 Gene

中文名称:腺苷同型半胱氨酸酶样 1

种属: Homo sapiens

同用名: DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA

基因 ID: 10768 | 基因类型: protein coding

关于 AHCYL1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,984,765-110,023,742 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 81.1), duodenum (RPKM 50.1) and 25 other tissues.

功能概要

该基因编码的蛋白质与 1 型肌醇 1,4,5-三磷酸受体相互作用,可能参与 S-腺苷-L-高半胱氨酸向 L-高半胱氨酸和腺苷的转化。已发现该基因编码两种不同亚型的几种转录变体。[RefSeq 提供,2011 年 6 月]

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AHCYL1 基因产物(5)

mRNA Protein Name
NM_001242673.2 NP_001229602.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242674.2 NP_001229603.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242675.2 NP_001229604.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242676.2 NP_001229605.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_006621.7 NP_006612.2 S-adenosylhomocysteine hydrolase-like protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16769890 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiotensin-activated signaling pathway IDA
IDA: 通过直接分析推断
20584908 GOA
involved in apoptotic process IMP
IMP: 通过突变表型推断
27995898 GOA
involved in mitochondrion-endoplasmic reticulum membrane tethering IMP
IMP: 通过突变表型推断
27995898 GOA
involved in positive regulation of sodium ion transport IMP
IMP: 通过突变表型推断
16769890 GOA
involved in regulation of mRNA 3'-end processing IDA
IDA: 通过直接分析推断
19224921 GOA
involved in regulation of monoatomic ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
16769890 GOA
involved in response to calcium ion IDA
IDA: 通过直接分析推断
18829453 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
27995898 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AHCYL1 蛋白结构

AdoHcyase

AdoHcyase: S-adenosyl-L-homocysteine hydrolase (104 - 529)

AdoHcyase_NAD

AdoHcyase_NAD: S-adenosyl-L-homocysteine hydrolase, NAD binding domain (289 - 449)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 530 a.a.
蛋白主名 其他名称

S-adenosylhomocysteine hydrolase-like protein 1

DC-expressed AHCY-like molecule

AHCYL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AHCYL1 O43865 ZNF165 Homo sapiens Q53Z40
Validated Y2H
25416956
种属内
AHCYL1 O43865 ZNF165 Homo sapiens Q53Z40
Y2H Prey Pooling
25416956
种属内
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2
Validated Y2H
25416956
种属内
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2
Y2H Prey Pooling
32296183
种属内
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2
Validated Y2H
32296183
种属内
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2
Y2H Array
25416956
种属内
AHCYL1 O43865 DACH1 Homo sapiens Q9UI36-2
Y2H Array
32296183
种属内
AHCYL1 O43865 HBQ1 Homo sapiens P09105
Y2H Prey Pooling
32296183
种属内
AHCYL1 O43865 HBQ1 Homo sapiens P09105
Y2H Array
32296183
种属内
AHCYL1 O43865 HBQ1 Homo sapiens P09105
Validated Y2H
32296183
种属内
AHCYL1 O43865 HBQ1 Homo sapiens P09105
MAPPIT
32296183
种属内
AHCYL1 O43865 BID Homo sapiens P55957-2
Validated Y2H
25416956
种属内
AHCYL1 O43865 BID Homo sapiens P55957-2
Y2H Array
25416956
种属内
AHCYL1 O43865 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
种属内
AHCYL1 O43865 PLEKHG5 Homo sapiens O94827-4
Validated Y2H
32296183
种属内
AHCYL1 O43865 SLC23A1 Homo sapiens Q9UHI7-3
Validated Y2H
32296183
种属内
AHCYL1 O43865 JOSD2 Homo sapiens Q8TAC2
Validated Y2H
32296183
种属内
AHCYL1 O43865 JOSD2 Homo sapiens Q8TAC2
Y2H Prey Pooling
32296183
种属内
AHCYL1 O43865 JOSD2 Homo sapiens Q8TAC2
Y2H Array
32296183
种属内
AHCYL1 O43865 SLC23A1 Homo sapiens Q9UHI7
Y2H Prey Pooling
25416956
种属内
AHCYL1 O43865 BCL2L10 Homo sapiens Q9HD36
Anti Bait CoIP
27995898
种属内
AHCYL1 O43865 BCL2L10 Homo sapiens Q9HD36
Anti Tag CoIP
27995898
种属内
AHCYL1 O43865 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
32296183
种属内
AHCYL1 O43865 CDKN2C Homo sapiens P42773
Y2H Array
31515488
种属内
AHCYL1 O43865 CDKN2C Homo sapiens P42773
Y2H Prey Pooling
25416956
种属内
AHCYL1 O43865 CDKN2C Homo sapiens P42773
Validated Y2H
25416956
种属内
AHCYL1 O43865 CDKN2C Homo sapiens P42773
Validated Y2H
32296183
种属内
AHCYL1 O43865 UACA Homo sapiens Q9BZF9
Validated Y2H
32296183
种属内
AHCYL1 O43865 HSPA6 Homo sapiens P17066
Validated Y2H
32296183
种属内
AHCYL1 O43865 HSPA6 Homo sapiens P17066
Y2H Array
32296183
种属内
AHCYL1 O43865 HSPA6 Homo sapiens P17066
Y2H Prey Pooling
32296183
种属内
AHCYL1 O43865 PPL Homo sapiens O60437
Y2H Array
25416956
种属内
AHCYL1 O43865 PPL Homo sapiens O60437
Validated Y2H
25416956
种属内
AHCYL1 O43865 BID Homo sapiens P55957
Validated Y2H
25416956
种属内
AHCYL1 O43865 BID Homo sapiens P55957
Y2H Array
25416956
种属内
AHCYL1 O43865 BID Homo sapiens P55957
Y2H Prey Pooling
25416956
种属内
AHCYL1 O43865 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
种属内
AHCYL1 O43865 MAGEA2 Homo sapiens P43356
Y2H Array
32814053
种属内
AHCYL1 O43865 MAGEA2 Homo sapiens P43356
Y2H Pooling
32814053
种属内
AHCYL1 O43865 MAGEA2 Homo sapiens P43356
Validated Y2H
32814053
种属内
AHCYL1 O43865 ZNF165 Homo sapiens P49910
Validated Y2H
32296183
种属内
AHCYL1 O43865 ZNF165 Homo sapiens P49910
Y2H Prey Pooling
32296183
种属内
AHCYL1 O43865 ZNF165 Homo sapiens P49910
Y2H Array
32296183
种属内
AHCYL1 O43865 SOX30 Homo sapiens O94993
Y2H Array
25416956
种属内
AHCYL1 O43865 GEM Homo sapiens P55040
Validated Y2H
32296183
种属内
AHCYL1 O43865 GEM Homo sapiens P55040
Y2H Array
25416956
种属内
AHCYL1 O43865 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属内
AHCYL1 O43865 MEOX2 Homo sapiens P50222
Y2H Array
25416956
种属内
AHCYL1 O43865 PSMD9 Homo sapiens O00233
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intestinal Impaction
Spinocerebellar Ataxia 29

Spinocerebellar Ataxia Type 29

SCA29

Cnpca

Cerebellar Vermis Aplasia

Aplasia Of Cerebellar Vermis

Acv

Cerebellar Ataxia, Congenital Nonprogressive, Autosomal Dominant

Spinocerebellar Ataxia 29, Congenital Nonprogressive

Congenital Nonprogressive Spinocerebellar Ataxia

Autosomal Dominant Congenital Nonprogressive Cerebellar Ataxia

Ataxia, Spinocerebellar, Type 29, Congenital Nonprogressive

Familial Aplasia Of The Vermis

Cerebral Palsy, Ataxic, Autosomal Recessive

Ataxic Cerebral Palsy

Acp

Hypotonic Cerebral Palsy

Cerebral Palsy Ataxic

Cerebral Palsy, Atonic

Congenital Cerebral Palsy With Ataxia

Ataxic Cerebral Paralysis

Ataxia With Cerebral Palsy

Cerebral Infantile Diataxia

Spinocerebellar Ataxia, Autosomal Recessive 13

Autosomal Recessive Spinocerebellar Ataxia 13

SCAR13

Autosomal Recessive Congenital Cerebellar Ataxia Due To Mglur1 Deficiency

Autosomal Recessive Congenital Cerebellar Ataxia Due To Metabotropic Glutamate Receptor 1 Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 13

Spinocerebellar Ataxia, Autosomal Recessive, 13

Ataxia, Spinocerebellar, Autosomal Recessive, Type 13

Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6

Kallmann Syndrome 6

Kal6

Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia

Gillespie Syndrome

GLSP

Aniridia, Cerebellar Ataxia And Mental Deficiency

Aniridia Cerebellar Ataxia Mental Deficiency

Aniridia, Cerebellar Ataxia, And Mental Retardation

Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome

Aniridia-Cerebellar Ataxia-Intellectual Disability

Aniridia-Cerebellar Ataxia-Mental Deficiency

Partial Aniridia-Cerebellar Ataxia-Oligophrenia

Aniridia, Cerebellar Ataxia, And Intellectual Disability

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AHCYL1 VGNC VGNC:37725
Felis catus AHCYL1 VGNC VGNC:80130
Rattus norvegicus AHCYL1 RGD RGD:1309768
Mus musculus AHCYL1 MGD MGI:2385184
Macaca mulatta AHCYL1 VGNC VGNC:81350
Bos taurus AHCYL1 VGNC VGNC:25751