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  2. BCL2L10 - BCL2 like 10 Gene

BCL2L10 - BCL2 like 10 Gene

中文名称:BCL2 样 10

种属: Homo sapiens

同用名: Boo; Diva; BCL-B; bcl2-L-10

基因 ID: 10017 | 基因类型: protein coding

关于 BCL2L10

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,109,263-52,112,775 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 8 paralogues. Broad expression in skin (RPKM 2.0), kidney (RPKM 1.9) and 15 other tissues.

功能概要

该基因编码的蛋白质属于 Bcl-2 蛋白家族。 Bcl-2 家族成员形成异二聚体或同二聚体,并作为参与多种细胞活动的抗或促凋亡调节剂。该基因编码的蛋白质包含保守的 BH4、BH1 和 BH2 结构域。该蛋白可以与 Bcl-2 蛋白家族的其他成员相互作用,包括 BCL2、BCL2L1/BCL-X (L) 和 Bax。该基因的过表达已被证明可能通过阻止细胞色素 C 从线粒体中释放来抑制细胞凋亡,从而激活 Caspase-3 激活。发现该蛋白质的小鼠对应物与 Apaf1 相互作用并与 Caspase 9 形成蛋白质复合物,这表明该蛋白质参与 APAF1 和 Caspase 9 相关的细胞凋亡途径。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of Bcl-2 protein family including BCL2, BCL2L1/BCL-X(L), and Bax. Overexpression of this gene has been shown to suppress cell Apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating Caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and Caspase 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

BCL2L10 基因产物(2)

mRNA Protein Name
NM_001306168.1 NP_001293097.1 bcl-2-like protein 10 isoform 1
NM_020396.4 NP_065129.1 bcl-2-like protein 10 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IMP
IMP: 通过突变表型推断
21705382 GOA
enables caspase binding IPI
IPI: 通过物理相互作用推断
19255499 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11278245 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic process IMP
IMP: 通过突变表型推断
27995898 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
11278245 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11278245 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
22498477 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
27995898 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
11278245 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BCL2L10 蛋白结构

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (49 - 163)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

bcl-2-like protein 10

BCL2-like 10 (apoptosis facilitator)

anti-apoptotic protein Boo

anti-apoptotic protein NrH

apoptosis regulator Bcl-B

death inducer binding to vBcl-2 and Apaf-1

BCL2L10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BCL2L10 Q9HD36 SAMD4B Homo sapiens Q5PRF9
Y2H Prey Pooling
32296183
Intra BCL2L10 Q9HD36 SAMD4B Homo sapiens Q5PRF9
Y2H Array
32296183
Intra BCL2L10 Q9HD36 MGST2 Homo sapiens Q99735
Y2H Prey Pooling
32296183
Intra BCL2L10 Q9HD36 MGST2 Homo sapiens Q99735
Y2H Array
32296183
Intra BCL2L10 Q9HD36 TMEM200A Homo sapiens Q86VY9
Y2H Prey Pooling
32296183
Intra BCL2L10 Q9HD36 TMEM200A Homo sapiens Q86VY9
Y2H Array
32296183
Intra BCL2L10 Q9HD36 AHCYL1 Homo sapiens O43865
BN-PAGE
27995898
Intra BCL2L10 Q9HD36 BMF Homo sapiens Q96LC9
Y2H Prey Pooling
32296183
Intra BCL2L10 Q9HD36 BMF Homo sapiens Q96LC9
Y2H Array
32296183
Intra BCL2L10 Q9HD36 ITPR1 Homo sapiens Q14643
BN-PAGE
27995898
Intra BCL2L10 Q9HD36 BAX Homo sapiens Q07812
Anti Tag CoIP
23235460
Intra BCL2L10 Q9HD36 BAX Homo sapiens Q07812
Anti Tag CoIP
33961781
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
Y2H Array
32296183
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
SPR
23235460
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
DLS
23235460
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
Anti Tag CoIP
33961781
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
Y2H Prey Pooling
32296183
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
CD
23235460
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
X-Ray Diffraction
23235460
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
GMS
23235460
Intra BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521-1
Anti Tag CoIP
23235460
Intra BCL2L10 Q9HD36 BIK Homo sapiens Q13323
Anti Tag CoIP
23235460
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BCL2L10 VGNC VGNC:84313
Mus musculus BCL2L10 MGD MGI:1330841
Rattus norvegicus BCL2L10 RGD RGD:621015