1. Gene
  2. BCL2L11 - BCL2 like 11 Gene

BCL2L11 - BCL2 like 11 Gene

中文名称:BCL2 样 11

种属: Homo sapiens

同用名: BAM; BIM; BOD

基因 ID: 10018 | 基因类型: protein coding

关于 BCL2L11

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,120,914-111,168,445 (from NCBI)

This gene has 23 transcripts (splice variants), 116 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.9), thyroid (RPKM 7.1) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 Bcl-2 蛋白家族。 Bcl-2 家族成员形成异二聚体或同二聚体,并作为参与多种细胞活动的抗或促凋亡调节剂。该基因编码的蛋白质含有 Bcl-2 同源结构域 3 (BH3) 。它已被证明与 Bcl-2 蛋白家族的其他成员相互作用,并充当细胞凋亡激活剂。该基因的表达可由神经生长因子 (NGF) 以及叉头转录因子 FKHR-L1 诱导,这表明该基因在神经元和淋巴细胞凋亡中的作用。小鼠对应物的转基因研究表明,该基因在胸腺细胞阴性选择中作为细胞凋亡的重要启动子发挥作用。已经鉴定了该基因的几种可变剪接的转录物变体。[RefSeq 提供,2013 年 6 月]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte Apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of Apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

BCL2L11 基因产物(33)

mRNA Protein Name
XM_005263556.4 XP_005263613.1 bcl-2-like protein 11 isoform X8
XM_017003101.3 XP_016858590.1 bcl-2-like protein 11 isoform X12
NM_001204109.2 NP_001191038.1 bcl-2-like protein 11 isoform 14
XM_047442101.1 XP_047298057.1 bcl-2-like protein 11 isoform X5
XM_047442102.1 XP_047298058.1 bcl-2-like protein 11 isoform X6
NM_138627.4 NP_619533.1 bcl-2-like protein 11 isoform 8
NM_138626.4 NP_619532.1 bcl-2-like protein 11 isoform 7
NM_138623.4 NP_619529.1 bcl-2-like protein 11 isoform 3
NM_138624.4 NP_619530.1 bcl-2-like protein 11 isoform 4
XM_047442104.1 XP_047298060.1 bcl-2-like protein 11 isoform X11
NM_207003.3 NP_996886.1 bcl-2-like protein 11 isoform 10
NM_138621.5 NP_619527.1 bcl-2-like protein 11 isoform 1
XM_005263555.5 XP_005263612.2 bcl-2-like protein 11 isoform X7
XM_005263557.5 XP_005263614.1 bcl-2-like protein 11 isoform X8
XM_005263553.4 XP_005263610.1 bcl-2-like protein 11 isoform X4
NM_006538.5 NP_006529.1 bcl-2-like protein 11 isoform 6
XM_005263559.4 XP_005263616.2 bcl-2-like protein 11 isoform X10
XR_007068187.1
NM_138625.4 NP_619531.1 bcl-2-like protein 11 isoform 5
NM_001204112.2 NP_001191041.1 bcl-2-like protein 11 isoform 17
XR_007068189.1
XM_011510464.4 XP_011508766.1 bcl-2-like protein 11 isoform X9
NM_207002.3 NP_996885.1 bcl-2-like protein 11 isoform 9
XM_047442099.1 XP_047298055.1 bcl-2-like protein 11 isoform X2
NM_138622.4 NP_619528.1 bcl-2-like protein 11 isoform 2
NM_001204113.1 NP_001191042.1 bcl-2-like protein 11 isoform 18
NM_001204107.1 NP_001191036.1 bcl-2-like protein 11 isoform 12
NM_001204110.2 NP_001191039.1 bcl-2-like protein 11 isoform 15
NM_001204108.1 NP_001191037.1 bcl-2-like protein 11 isoform 13
XM_005263552.5 XP_005263609.1 bcl-2-like protein 11 isoform X3
NM_001204111.2 NP_001191040.1 bcl-2-like protein 11 isoform 16
XM_011510461.4 XP_011508763.2 bcl-2-like protein 11 isoform X1
NM_001204106.2 NP_001191035.1 bcl-2-like protein 11 isoform 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to microtubule binding IDA
IDA: 通过直接分析推断
21671007 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14596824 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of BIM-BCL-2 complex IDA
IDA: 通过直接分析推断
21671007 GOA
part of BIM-BCL-xl complex IDA
IDA: 通过直接分析推断
21671007 GOA
part of Bcl-2 family protein complex IPI
IPI: 通过物理相互作用推断
20066663 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21671007 GOA
colocalizes with microtubule IDA
IDA: 通过直接分析推断
21671007 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BCL2L11 蛋白结构

Bim_N

Bim_N: Bim protein N-terminus (4 - 40)

Bclx_interact

Bclx_interact: Bcl-x interacting, BH3 domain (131 - 166)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

bcl-2-like protein 11

BCL2-like 11 (apoptosis facilitator)

bcl-2 interacting mediator of cell death

bcl-2 interacting protein Bim

bcl-2-related ovarian death agonist

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

Interleukin-7 Receptor Alpha Deficiency

Il-7r

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Buruli Ulcer

Buruli Ulcer, Susceptibility To

Buruli Ulcer Disease

Mycobacterium Ulcerans

Mycobacterium Ulcerans, Susceptibility To

Bairnsdale Ulcer

Daintree Ulcer

Mossman Ulcer

Searl Ulcer

Searle'S Ulcer

Bud

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD

Autoimmune Lymphoproliferative Syndrome Type 4

Alps4

Autoimmune Lymphoproliferative Syndrome, Type Iv

Ras-Associated Autoimmune Leukoproliferative Disease

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic

Alps Type 4

Alps Type Iv

Autoimmune Lymphoproliferative Syndrome Type Iv

Autoimmune Lymphoproliferative Syndrome 4

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm

Neoplasm Of Mature B-Cells

Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Myasthenic Syndrome, Congenital, 3a, Slow-Channel

Congenital Myasthenic Syndrome 3a

CMS3A

Congenital Myasthenic Syndrome 3a, Slow-Channel

Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus BCL2L11 MGD MGI:1197519
Felis catus BCL2L11 VGNC VGNC:99046
Macaca mulatta BCL2L11 VGNC VGNC:97737
Rattus norvegicus BCL2L11 RGD RGD:628774
Canis familiaris BCL2L11 VGNC VGNC:54922
Bos taurus BCL2L11 VGNC VGNC:50256