Mcl1 - myeloid cell leukemia sequence 1 Gene

中文名称：骨髓细胞白血病序列 1

种属: Mus musculus

同用名: Mcl-1

关于 Mcl1

功能概要

该基因编码的蛋白可启动 BH3 域绑定活动。在没有配体的情况下参与外源性凋亡信号通路；细胞凋亡过程的负调控；和氧化应激诱导的神经元内在凋亡信号通路的正调控。作用于凋亡线粒体变化和内在凋亡信号通路的上游或内部，以响应 DNA 损伤。位于几种细胞成分中，包括细胞质；线粒体基质；和核。以多种结构表达，包括消化系统；胚泡;脑;泌尿生殖系统；和淋巴系统腺体。与人类 MCL1 同源（MCL1 细胞凋亡调节因子，BCL2 家族成员）。 [由基因组资源联盟提供，2022 年 4 月]

Enables BH3 domain binding activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; and positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within apoptotic mitochondrial changes and intrinsic apoptotic signaling pathway in response to DNA damage. Located in several cellular components, including cytosol; mitochondrial matrix; and nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human MCL1 (MCL1 Apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Apr 2022]