2. Gene
  3. Pmaip1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

Pmaip1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Noxa

基因 ID: 58801 | 基因类型: protein coding

关于 Pmaip1

功能概要

Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and negative regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and response to X-ray. Located in mitochondrion. Is expressed in several structures, including brain; immune system; limb; liver; and reproductive system. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pmaip1 基因产物(1)

mRNA Protein Name
NM_021451.2 NP_067426.1 phorbol-12-myristate-13-acetate-induced protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15694340 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
12952892 MGI
involved in T cell homeostasis IMP
IMP: 通过突变表型推断
18411339 MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
14699081 MGI
acts upstream of fibroblast apoptotic process IMP
IMP: 通过突变表型推断
14500851 MGI
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
14500851 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
12952892 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: 通过直接分析推断
10807576 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
16407291 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
12952892 MGI
involved in negative regulation of mitochondrial membrane potential IDA
IDA: 通过直接分析推断
14699081 MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
14500851 MGI
acts upstream of or within positive regulation of establishment of protein localization to mitochondrion IMP
IMP: 通过突变表型推断
12952892 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IMP
IMP: 通过突变表型推断
14500851 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
15703398 MGI
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
14699081 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
12952892 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
12952892 MGI
acts upstream of or within response to X-ray IMP
IMP: 通过突变表型推断
12952892 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
10807576 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

phorbol-12-myristate-13-acetate-induced protein 1

protein Noxa

Pmaip1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Pmaip1 Q9JM54 MCL1 Homo sapiens Q07820
FPS
16697956
种属内
Pmaip1 Q9JM54 Mcl1 Mus musculus P97287
ITC
17389404
种属内
Pmaip1 Q9JM54 Mcl1 Mus musculus P97287
Anti Bait CoIP
20627101
种属内
Pmaip1 Q9JM54 Mcl1 Mus musculus P97287
Anti Tag CoIP
20627101
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10758 PMAIP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pmaip1 NCBI NCBI:5366
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