2. Gene
  3. PMAIP1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

PMAIP1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：phorbol-12-myristate-13-acetate 诱导蛋白 1

种属: Homo sapiens

同用名: APR; NOXA

基因 ID: 5366 | 基因类型: protein coding

关于 PMAIP1

Cytogenetic location: 18q21.32 Genomic coordinates (GRCh38): 18:59,899,996-59,904,305 (from NCBI)

This gene has 3 transcripts (splice variants) and 50 orthologues. Biased expression in bone marrow (RPKM 33.1), placenta (RPKM 8.9) and 12 other tissues.

功能概要

该基因属于 Bcl-2 蛋白家族中的促凋亡亚家族，称为 Bcl-2 同源结构域 3 (BH3) -only 亚家族，它决定细胞是否会发生凋亡。响应死亡诱导刺激，BH3-only 成员抑制抗凋亡 Bcl-2 家族成员，其在稳态条件下保持多 BH 结构域蛋白 Bax 和 Bak 处于非活性状态。[RefSeq 提供，2020 年 8 月]

This gene belongs to a pro-apoptotic subfamily within the Bcl-2 protein family, referred to as the Bcl-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to Apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic Bcl-2 Family members, which under steady-state conditions keep the multi-BH domain proteins Bax and Bak, in an inactive state. [provided by RefSeq, Aug 2020]

PMAIP1 基因产物(6)

mRNA Protein Name
NM_001382615.1 NP_001369544.1 phorbol-12-myristate-13-acetate-induced protein 1 isoform 5
NM_001382616.1 NP_001369545.1 phorbol-12-myristate-13-acetate-induced protein 1 isoform 1
NM_001382617.1 NP_001369546.1 phorbol-12-myristate-13-acetate-induced protein 1 isoform 3
NM_001382618.1 NP_001369547.1 phorbol-12-myristate-13-acetate-induced protein 1 isoform 2
NM_001382623.1 NP_001369552.1 phorbol-12-myristate-13-acetate-induced protein 1 isoform 4
NM_021127.3 NP_066950.1 phorbol-12-myristate-13-acetate-induced protein 1 isoform 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15705586 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
17599062 GOA
involved in cellular response to glucose starvation IMP
IMP: 通过突变表型推断
21145489 GOA
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
14699081 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
15705586 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
14500711 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
15102863 GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
15102863 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
21132008 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17289999 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
14699081 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
15705586 GOA
involved in positive regulation of glucose metabolic process IDA
IDA: 通过直接分析推断
21145489 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
21454712 GOA
involved in positive regulation of release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
14500711 GOA
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
15705586 GOA
involved in proteasomal protein catabolic process IDA
IDA: 通过直接分析推断
15901672 GOA
involved in reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
14699081 GOA
involved in regulation of mitochondrial membrane permeability IDA
IDA: 通过直接分析推断
14500711 GOA
involved in response to dsRNA IDA
IDA: 通过直接分析推断
15705586 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Bcl-2 family protein complex IPI
IPI: 通过物理相互作用推断
21132008 GOA
located in cytosol IDA
IDA: 通过直接分析推断
15705586 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
14500711 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12879012 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PMAIP1 蛋白结构

PMAIP1

PMAIP1: Phorbol-12-myristate-13-acetate-induced (1 - 54)

  • 0
  • 54 a.a.
蛋白主名 其他名称

phorbol-12-myristate-13-acetate-induced protein 1

PMA-induced protein 1

PMAIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PMAIP1 Q13794 BCL2 Homo sapiens P10415-1
Pull Down
21454712
种属内
PMAIP1 Q13794 BCL2 Homo sapiens P10415
Pull Down
21454712
种属内
PMAIP1 Q13794 BCL2 Homo sapiens P10415
Anti Bait CoIP
21454712
种属间: 跨种属相互作用 种属内: 同种属相互作用

PMAIP1 抗体

目录号 产品名 应用 反应物种
HY-P82808 NOXA Antibody (YA2553) WB Human

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Rhabdomyosarcoma
Pyriform Sinus Cancer

Malignant Neoplasm Of Pyriform Fossa

Malignant Neoplasm Of The Pyriform Fossa

Malignant Tumor Of Pyriform Fossa
Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Familial Hyperinsulinemic Hypoglycemia 1

Congenital Hyperinsulinism

Phhi

Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Of Infancy

Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

Nesidioblastosis Of Pancreas

Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

Hyperinsulinism, Congenital

Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Familial, Type 1
Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni

Sbla Syndrome

LFS

Li-Fraumeni Familiar Cancer Susceptibility Syndrome

Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome

Lfs1

Li Fraumeni Syndrome

Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome

Lfl

Sbla Syndrome Li-Fraumeni-Like Syndrome

Li-Fraumeni Syndrome 1
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10758 PMAIP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PMAIP1 VGNC VGNC:53752
Bos taurus PMAIP1 VGNC VGNC:106870
Mus musculus PMAIP1 MGD MGI:1930146
Rattus norvegicus PMAIP1 RGD RGD:1359266
Felis catus PMAIP1 VGNC VGNC:107717
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