1. Gene
  2. BAK1 - BCL2 antagonist/killer 1 Gene

BAK1 - BCL2 antagonist/killer 1 Gene

中文名称:BCL2 拮抗因子/杀手 1

种属: Homo sapiens

同用名: BAK; CDN1; BCL2L7; BAK-LIKE

基因 ID: 578 | 基因类型: protein coding

关于 BAK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,572,552-33,580,276 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 8 paralogues. Ubiquitous expression in duodenum (RPKM 20.6), small intestine (RPKM 16.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 BCL2 蛋白家族。 BCL2 家族成员形成寡聚体或异二聚体,并充当参与多种细胞活动的抗或促凋亡调节剂。这种蛋白质定位于线粒体,并起到诱导细胞凋亡的作用。它与线粒体电压依赖性阴离子通道相互作用并加速开放,导致膜电位损失和细胞色素 c 的释放。在暴露于细胞应激后,该蛋白质还与肿瘤抑制因子 P53 相互作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce Apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

BAK1 基因产物(5)

mRNA Protein Name
NM_001188.4 NP_001179.1 bcl-2 homologous antagonist/killer
XM_047419196.1 XP_047275152.1 bcl-2 homologous antagonist/killer isoform X3
XM_047419194.1 XP_047275150.1 bcl-2 homologous antagonist/killer isoform X2
XM_011514780.2 XP_011513082.1 bcl-2 homologous antagonist/killer isoform X3
XM_011514779.4 XP_011513081.1 bcl-2 homologous antagonist/killer isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10950869 GOA
enables porin activity IDA
IDA: 通过直接分析推断
22006182 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9027312 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
10837489 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
23028632 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
25296756 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
18387192 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
23028632 GOA
involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15901672 GOA
involved in cellular response to UV IMP
IMP: 通过突变表型推断
15901672 GOA
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in establishment or maintenance of transmembrane electrochemical gradient IDA
IDA: 通过直接分析推断
9843949 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
22006182 GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
15901672 GOA
involved in negative regulation of release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
15901672 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17289999 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
9111042 GOA
involved in positive regulation of proteolysis IDA
IDA: 通过直接分析推断
18387192 GOA
involved in regulation of mitochondrial membrane permeability IDA
IDA: 通过直接分析推断
9843949 GOA
involved in regulation of mitochondrial membrane potential IDA
IDA: 通过直接分析推断
9843949 GOA
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
9843949 GOA
involved in release of cytochrome c from mitochondria IGI
IGI: 通过遗传相互作用推断
21041309 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of BAK complex IDA
IDA: 通过直接分析推断
10950869 GOA
part of BAK complex IPI
IPI: 通过物理相互作用推断
32929280 GOA
part of Bcl-2 family protein complex IDA
IDA: 通过直接分析推断
21041309 GOA
part of Bcl-2 family protein complex IPI
IPI: 通过物理相互作用推断
22515821 GOA
is active in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
22006182 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
29531808 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
9843949 GOA
part of pore complex IDA
IDA: 通过直接分析推断
9843949 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BAK1 蛋白结构

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (78 - 177)

  • 0
  • 100
  • 211 a.a.
蛋白主名 其他名称

bcl-2 homologous antagonist/killer

BCL2-like 7 protein

apoptosis regulator BAK

bcl-2-like protein 7

bcl2-L-7

pro-apoptotic protein BAK

BAK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BAK1 Q16611 MCL1 Homo sapiens Q07820
Anti Bait CoIP
17097560
种属内
BAK1 Q16611 MCL1 Homo sapiens Q07820
Anti Tag CoIP
19968986
种属内
BAK1 Q16611 MCL1 Homo sapiens Q07820
Anti Bait CoIP
23680104
种属内
BAK1 Q16611 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
种属内
BAK1 Q16611 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
种属内
BAK1 Q16611 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817-1
FPS
17446862
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817-1
Anti Bait CoIP
15901672
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817-1
HTRF
14596824
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817-1
SPA
14596824
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817-1
Anti Bait CoIP
23680104
种属内
BAK1 Q16611 BAX Homo sapiens Q07812
Anti Tag CoIP
33961781
种属内
BAK1 Q16611 BAX Homo sapiens Q07812
CoIP
16439990
种属内
BAK1 Q16611 BID Homo sapiens P55957
Photoaffinity Labelling
12624108
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Y2H Array
31515488
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
SLC
31467278
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Lumier
32814053
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Complementation
31467278
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Lumier
29997244
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Lumier
37398436
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
BRET
29997244
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Y2H Pooling
16189514
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
Y2H Array
31467278
种属内
BAK1 Q16611 BCL2L1 Homo sapiens Q07817
BRET
37398436
种属间
BAK1 Q16611 Mcl1 Mus musculus P97287
SPR
15901672
种属内
BAK1 Q16611 BCL2L2 Homo sapiens Q92843
Validated Y2H
25416956
种属内
BAK1 Q16611 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
种属内
BAK1 Q16611 BCL2L2 Homo sapiens Q92843
Y2H Array
25416956
种属内
BAK1 Q16611 BCL2 Homo sapiens P10415
FPS
26004684
种属内
BAK1 Q16611 BCL2 Homo sapiens P10415
Anti Bait CoIP
9463381
种属间
BAK1 Q16611 OPG045 vaccinia virus P24356
CoIP
16439990
种属间
BAK1 Q16611 OPG045 vaccinia virus P24356
Pull Down
16439990
种属间
BAK1 Q16611 OPG045 vaccinia virus P24356
Peptide Array
16439990
种属间
BAK1 Q16611 OPG045 vaccinia virus P24356
Competition Binding
16439990
种属间
BAK1 Q16611 Mfn2 Mus musculus Q80U63
FRET
17606912
种属间
BAK1 Q16611 Mfn2 Mus musculus Q80U63
Anti Tag CoIP
17606912
种属间: 跨种属相互作用 种属内: 同种属相互作用

BAK1 抗体

目录号 产品名 应用 反应物种
HY-P80563 Bak Antibody WB, IHC-P, ICC/IF, IP, FC Human, Mouse

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Follicular Lymphoma

Lymphoma, Follicular

Lymphoma Follicular

Brill-Symmers' Disease

Large Cell Follicular Non-Hodgkin Lymphoma

Diffuse Follicle Centre Lymphoma

Diffuse Follicular Lymphoma Nos

Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

Follicular Large Cell Cleaved Or Noncleaved Lymphoma

Large Cell Follicular Noncleaved Lymphoma

Follicular Lymphoma With Or Without Diffuse Areas

Histiocytic Follicular Lymphoma

Histiocytic Nodular Lymphoma

Histiocytic Nodular Malignant Lymphoma

Large Cell Follicular Lymphoma

Large Cell Noncleaved Follicular Lymphoma

Large Cell Noncleaved Follicular Malignant Lymphoma

Nodular Reticulum Cell Sarcoma

Noncleaved Follicular Lymphoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes

Childhood Germ Cell Cancer

Pediatric Germ Cell Tumor

Paediatric Germ Cell Cancer

Paediatric Germ Cell Neoplasm

Pediatric Germ Cell Cancer

Pediatric Germ Cell Neoplasm

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Absolute Glaucoma

Blind Hypertensive Eye

Glaucoma Absolute

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Breast Disease

Breast Diseases

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BAK1 VGNC VGNC:70224
Rattus norvegicus BAK1 RGD RGD:621635
Mus musculus BAK1 MGD MGI:1097161
Felis catus BAK1 VGNC VGNC:102386
Bos taurus BAK1 VGNC VGNC:26416
Canis familiaris BAK1 VGNC VGNC:38375
Others BAK1 NCBI