2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Dibenzyl trisulfide

Dibenzyl trisulfide  (Synonyms: DTS)

目录号: HY-129461
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摩尔计算器

Dibenzyl trisulfide (DTS) 是 Petiveria alliacea L. 分离得到的一种活性成分。Dibenzyl trisulfide 抑制细胞增殖和迁移。Dibenzyl trisulfide 降低了 BAK-1 和 LTA 的 mRNA 和蛋白质表达。Dibenzyl trisulfide 诱导溶酶体膜通透性和组织蛋白酶 B 释放。

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Dibenzyl trisulfide Chemical Structure

Dibenzyl trisulfide Chemical Structure

CAS No. : 6493-73-8

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Dibenzyl trisulfide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release[1].

体外研究
(In Vitro)

Dibenzyl trisulfide (0.1-50 µM; 2 weeks) 抑制 CRL-2335 细胞增殖和迁移[1]。
Dibenzyl trisulfide (10, 50 µM) 以剂量依赖性方式降低 BAK-1 和 LTA 的 mRNA 和蛋白表达[1]。
Dibenzyl trisulfide (10 µM; 48 h) 诱导 CRL-2335 细胞中溶酶体膜通透性和组织蛋白酶 B 释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dibenzyl trisulfide 相关抗体:

Cell Proliferation Assay[1]

Cell Line: CRL-2335 cells
Concentration: 0.1, 0.5, 1, 10, 50 µM
Incubation Time: 2 weeks
Result: Inhibited proliferation and migration of CRL-2335 cell in a dose-dependent manner.

RT-PCR[1]

Cell Line: CRL-2335 cells
Concentration: 0, 10, 50 µM
Incubation Time: 48 h
Result: Decreased the mRNA expression of BAK-1, GADD45a, and LTA in a dose-dependent manner.

Immunofluorescence[1]

Cell Line: CRL-2335 cells
Concentration: 0, 10, 50 µM
Incubation Time: 48 h
Result: Decreased the protein expression of BAK-1 and LTA but not GADD45a.
分子量

278.46

Formula

C14H14S3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dibenzyl trisulfide 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dibenzyl trisulfide6493-73-8DTSCathepsinRL-2335 cellsBAK-1LTAcathepsin BInhibitorinhibitorinhibit

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