2. Academic Validation
  3. Synthesis and anti-tumor evaluation of new trisulfide derivatives

Synthesis and anti-tumor evaluation of new trisulfide derivatives

  • Bioorg Med Chem Lett. 2006 Sep 15;16(18):4826-9. doi: 10.1016/j.bmcl.2006.06.070.
Haoyun An 1,  Jenny Zhu,  Xiaobo Wang,  Xiao Xu
Affiliations

Affiliation

  • 1 ACEA Biosciences, Inc., 11585 Sorrento Valley Road, Suite 103, San Diego, CA 92121, USA. han@aceabio.com
PMID: 16828553 DOI: 10.1016/j.bmcl.2006.06.070
Abstract

New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z