2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. A-1208746

A-1208746 是 MCL-1 的抑制剂，Ki 为 0.454 nM。A-1208746 可激活 caspase-3/-7、诱导细胞 H929 细胞凋亡 (apoptosis)，并降低线粒体膜电位。A-1208746 与 Navitoclax (HY-10087) 发挥协同作用，可用于癌症研究。

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A-1208746 Chemical Structure

A-1208746 Chemical Structure

CAS No. : 1668553-23-8

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A-1208746 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-1208746 is an inhibitor for MCL-1, with a Ki of 0.454 nM. A-1208746 activates caspase-3/-7, induces apoptosis in cell H929, and decreases mitochondrial membrane potential. A-1208746 synergies with Navitoclax (HY-10087), and can be used in cancer research[1].

IC50 & Target

Ki: 0.454 nM (MCL-1)
分子量

821.00

Formula

C45H52N6O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-1208746 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-12087461668553-23-8A1208746A 1208746Bcl-2 FamilyApoptosisH929H1299multiple myelomanavitoclaxInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-W689801
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