2. Apoptosis
  3. Bcl-2 Family
  4. YCW-E11

YCW-E11 是一种 Bcl-2 和 Mcl-1 抑制剂，其 Ki 值分别为 0.83 和 0.33 μM。YCW-E11 通过线粒体途径诱导细胞凋亡，并表现出抗肿瘤活性。YCW-E11 可用于癌症研究。

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YCW-E11 Chemical Structure

YCW-E11 Chemical Structure

CAS No. : 1519043-97-0

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YCW-E11 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YCW-E11 is a Bcl-2, and Mcl-1 inhibitor with Ki values of 0.83 and 0.33 μM, respectively. YCW-E11 induces cell apoptosis through the mitochondrial pathway and exhibits antitumor activity. YCW-E11 can be utilized in cancer research[1].

IC50 & Target

Bcl-2

 

Mcl-1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T IC50
10.7 μM
Compound: YCW-E11
Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 34228434]
HeLa IC50
> 50 μM
Compound: YCW-E11
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 34228434]
HL-60 IC50
6.9 μM
Compound: YCW-E11
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 34228434]
RS4-11 IC50
6.2 μM
Compound: YCW-E11
Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 34228434]
分子量

594.49

Formula

C25H21Cl2N3O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YCW-E11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YCW-E111519043-97-0Bcl-2 FamilyBcl-2Mcl-1apoptosismitochondrial pathwayantitumorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-116532
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