2. Gene
  3. BBC3 - BCL2 binding component 3 Gene

BBC3 - BCL2 binding component 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BCL2 绑定组件 3

种属: Homo sapiens

同用名: JFY1; PUMA; JFY-1

基因 ID: 27113 | 基因类型: protein coding

关于 BBC3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,220,824-47,232,860 (from NCBI)

This gene has 6 transcripts (splice variants) and 56 orthologues. Ubiquitous expression in colon (RPKM 3.5), stomach (RPKM 1.4) and 24 other tissues.

功能概要

该基因编码 Bcl-2 蛋白质家族的成员。该家族成员属于 BH3-only 促凋亡亚类。该蛋白与直接激活蛋白协同作用，诱导线粒体外膜透化和细胞凋亡。它可以与抗凋亡 Bcl-2 家族成员结合，诱导线粒体功能障碍和半胱天冬酶激活。由于其促细胞凋亡作用，该基因是癌症治疗和组织损伤的潜在药物靶点。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the Bcl-2 Family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and Apoptosis. It can bind to anti-apoptotic Bcl-2 Family members to induce mitochondrial dysfunction and Caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for Cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

BBC3 基因产物(4)

mRNA Protein Name
NM_001127240.3 NP_001120712.1 bcl-2-binding component 3 isoform 1
NM_001127241.3 NP_001120713.1 bcl-2-binding component 3 isoform 2
NM_001127242.3 NP_001120714.1 bcl-2-binding component 3 isoform 3
NM_014417.5 NP_055232.1 bcl-2-binding component 3 isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
26212789 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11463391 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
11463392 GOA
involved in apoptotic process IMP
IMP: 通过突变表型推断
26212789 GOA
involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
11463392 GOA
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
20810912 GOA
involved in execution phase of apoptosis IDA
IDA: 通过直接分析推断
11463391 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
17024184 GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
16407291 GOA
involved in negative regulation of growth IMP
IMP: 通过突变表型推断
11463392 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
17289999 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
21041309 GOA
involved in positive regulation of release of cytochrome c from mitochondria IGI
IGI: 通过遗传相互作用推断
21041309 GOA
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
11463392 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
22761832 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with lysosome IDA
IDA: 通过直接分析推断
26212789 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
11463391 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bcl-2-binding component 3

p53 up-regulated modulator of apoptosis

BBC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BBC3 Q96PG8 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
种属内
BBC3 Q96PG8 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
种属内
BBC3 Q96PG8 NDUFAB1 Homo sapiens O14561
Y2H Prey Pooling
32296183
种属内
BBC3 Q96PG8 NDUFAB1 Homo sapiens O14561
Y2H Array
32296183
种属内
BBC3 Q96PG8 UBASH3B Homo sapiens Q8TF42
Y2H Array
32296183
种属内
BBC3 Q96PG8 UBASH3B Homo sapiens Q8TF42
Y2H Prey Pooling
32296183
种属内
BBC3 Q96PG8 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
种属内
BBC3 Q96PG8 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
种属内
BBC3 Q96PG8 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
种属内
BBC3 Q96PG8 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
种属内
BBC3 Q9BXH1 MCL1 Homo sapiens Q07820
Anti Bait CoIP
26431330
种属内
BBC3 Q9BXH1 MCL1 Homo sapiens Q07820
FPS
16697956
种属内
BBC3 Q9BXH1 BCL2L1 Homo sapiens Q07817-1
Anti Tag CoIP
15694340
种属内
BBC3 Q9BXH1 BCL2L1 Homo sapiens Q07817-1
SPR
16151013
种属内
BBC3 Q9BXH1 EGFR Homo sapiens P00533
Anti Bait CoIP
20153921
种属间
BBC3 Q9BXH1 Mcl1 Mus musculus P97287
Anti Bait CoIP
20627101
种属间
BBC3 Q9BXH1 Mcl1 Mus musculus P97287
Anti Tag CoIP
15694340
种属间
BBC3 Q9BXH1 Mcl1 Mus musculus P97287
Anti Tag CoIP
20627101
种属内
BBC3 Q9BXH1 BCL2L2 Homo sapiens Q92843
SPR
15694340
种属内
BBC3 Q9BXH1 BCL2L2 Homo sapiens Q92843
FPS
16697956
种属内
BBC3 Q9BXH1 BCL2 Homo sapiens P10415
Anti Tag CoIP
17289999
种属内
BBC3 Q9BXH1 BCL2 Homo sapiens P10415
Anti Bait CoIP
26431330
种属内
BBC3 Q9BXH1 BCL2 Homo sapiens P10415
Anti Tag CoIP
15694340
种属内
BBC3 Q9BXH1 BCL2 Homo sapiens P10415
FPS
16697956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01381 BBC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus BBC3 MGD MGI:2181667
Rattus norvegicus BBC3 RGD RGD:631434
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