2. Gene
  3. HSD17B13 - hydroxysteroid 17-beta dehydrogenase 13 Gene

HSD17B13 - hydroxysteroid 17-beta dehydrogenase 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羟基类固醇 17-β 脱氢酶 13

种属: Homo sapiens

同用名: FLDP; SCDR9; NIIL497; SDR16C3; HMFN0376

基因 ID: 345275 | 基因类型: protein coding

关于 HSD17B13

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,303,794-87,322,882 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 25 paralogues. Biased expression in liver (RPKM 126.6) and fat (RPKM 7.3).

功能概要

预测具有氧化还原酶活性，作用于 CH-OH 基团的供体，NAD 或 NADP 作为受体和类固醇脱氢酶活性。在脂质生物合成过程的上游或正调控中起作用。位于脂滴中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Acts upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]

HSD17B13 基因产物(2)

mRNA Protein Name
NM_001136230.3 NP_001129702.1 17-beta-hydroxysteroid dehydrogenase 13 isoform B
NM_178135.5 NP_835236.2 17-beta-hydroxysteroid dehydrogenase 13 isoform A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of lipid biosynthetic process IDA
IDA: 通过直接分析推断
25028495 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lipid droplet IDA
IDA: 通过直接分析推断
25028495 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSD17B13 蛋白结构

adh_short

adh_short: short chain dehydrogenase (38 - 203)

  • 0
  • 100
  • 200
  • 300 a.a.
蛋白主名 其他名称

17-beta-hydroxysteroid dehydrogenase 13

17-beta hydroxysteroid dehydrogenase

HSD17B13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSD17B13 Q7Z5P4 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SLC25A46 Homo sapiens Q96AG3
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SLC30A3 Homo sapiens Q99726
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 ADGRE2 Homo sapiens Q9UHX3
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 CLDND2 Homo sapiens Q8NHS1
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 ST6GAL2 Homo sapiens Q96JF0-2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 FETUB Homo sapiens Q9UGM5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 BBC3 Homo sapiens Q96PG8
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SCAMP5 Homo sapiens Q8TAC9
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM255B Homo sapiens Q8WV15
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 THSD7A Homo sapiens Q9UPZ6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SFXN2 Homo sapiens Q96NB2
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TBRG4 Homo sapiens Q969Z0
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TSPAN10 Homo sapiens Q9H1Z9
Anti Tag CoIP
33961781
种属内
HSD17B13 Q7Z5P4 TSPAN10 Homo sapiens Q9H1Z9
Anti Tag CoIP
28514442
种属内
HSD17B13 Q7Z5P4 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
种属内
HSD17B13 Q7Z5P4 CCDC167 Homo sapiens Q9P0B6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mucopolysaccharidosis Iii

Sanfilippo Syndrome

Mucopolysaccharidosis Type Iii

Mucopolysaccharidosis Type 3

Mps Iii

Mpsiii

Sanfilippo Disease

Heparan Sulfate Sulfatase Deficiency

Mucopolysaccharidosis, Mps-Iii

N-Sulphoglucosamine Sulphohydrolase Deficiency

Naglu Deficiency

Sanfilippo'S Syndrome

Mucopoly-Saccharidosis Type 3

Mps3

Sanfilippos Syndrome

Mucopolysaccharidosis Type Iiia

Mps Iii B
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Fatty Liver Disease

Alcoholic Fatty Liver

Fatty Liver

Fatty Liver, Alcoholic

Fatty Change Of Liver

Hepatic Lipidosis

Steatosis Of Liver

Fatty Liver Alcoholic

Steatohepatitis

Etoh Fatty Liver

Etoh Fatty Liver Metamorphosis

Fatty Etoh Liver Necrosis
Benign Meningioma

Meningioma, Benign
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (111)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148814 BI-3231 Inhibitor 99.83% 否
HY-W003696 tert-Butyl 5-bromoisoindoline-2-carboxylate 98.89% 否
HY-156735 HSD17B13-IN-2 Inhibitor 99.72% 否
HY-156736 HSD17B13-IN-3 Inhibitor 99.78% 否
HY-161227 HSD17B13-IN-43 Inhibitor 99.68% 否
HY-157627 HSD17B13-IN-9 Inhibitor 99.92% 否
HY-161212 HSD17B13-IN-8 Inhibitor 99.97% 否
HY-128145 HSD17B13-IN-41 Inhibitor / 否
HY-148926 HSD17B13-IN-1 Inhibitor / 否
HY-157601 HSD17B13-IN-4 Inhibitor / 否
HY-157613 HSD17B13-IN-5 Inhibitor / 否
HY-157615 HSD17B13-IN-6 Inhibitor / 否
HY-157630 HSD17B13-IN-10 Inhibitor / 否
HY-157632 HSD17B13-IN-13 Inhibitor / 否
HY-157650 HSD17B13-IN-20 Inhibitor / 否
HY-157653 HSD17B13-IN-22 Inhibitor / 否
HY-157654 HSD17B13-IN-26 Inhibitor / 否
HY-157662 HSD17B13-IN-33 Inhibitor / 否
HY-157663 HSD17B13-IN-36 Inhibitor / 否
HY-157664 HSD17B13-IN-38 Inhibitor / 否
HY-157665 HSD17B13-IN-39 Inhibitor / 否
HY-157667 HSD17B13-IN-44 Inhibitor / 否
HY-157671 HSD17B13-IN-45 Inhibitor / 否
HY-157674 HSD17B13-IN-46 Inhibitor / 否
HY-157676 HSD17B13-IN-47 Inhibitor / 否
HY-157708 HSD17B13-IN-67 Inhibitor / 否
HY-157710 HSD17B13-IN-68 Inhibitor / 否
HY-157717 HSD17B13-IN-70 Inhibitor / 否
HY-157720 HSD17B13-IN-72 Inhibitor / 否
HY-157722 HSD17B13-IN-73 Inhibitor / 否
HY-157723 HSD17B13-IN-74 Inhibitor / 否
HY-157724 HSD17B13-IN-76 Inhibitor / 否
HY-157726 HSD17B13-IN-77 Inhibitor / 否
HY-159651 PTOTAC HSD17B13 degrader 1 / 否
HY-159660 E3 ligase Ligand 31 / 否
HY-159661 E3 Ligase Ligand-linker Conjugate 114 / 否
HY-159662 HSD17B13 degrader 2 / 否
HY-161211 HSD17B13-IN-7 / 否
HY-161213 HSD17B13-IN-11 Inhibitor / 否
HY-161214 HSD17B13-IN-12 Inhibitor / 否
HY-161215 HSD17B13-IN-14 Inhibitor / 否
HY-161216 HSD17B13-IN-15 Inhibitor / 否
HY-161217 HSD17B13-IN-16 Inhibitor / 否
HY-161218 HSD17B13-IN-17 Inhibitor / 否
HY-161219 HSD17B13-IN-18 Inhibitor / 否
HY-161220 HSD17B13-IN-19 Inhibitor / 否
HY-161221 HSD17B13-IN-21 Inhibitor / 否
HY-161222 HSD17B13-IN-23 Inhibitor / 否
HY-161223 HSD17B13-IN-27 Inhibitor / 否
HY-161224 HSD17B13-IN-31 Inhibitor / 否
HY-161225 HSD17B13-IN-40 Inhibitor / 否
HY-161226 HSD17B13-IN-42 Inhibitor / 否
HY-161228 HSD17B13-IN-48 Inhibitor / 否
HY-161229 HSD17B13-IN-69 Inhibitor / 否
HY-161230 HSD17B13-IN-75 Inhibitor / 否
HY-161231 HSD17B13-IN-78 Inhibitor / 否
HY-161232 HSD17B13-IN-79 Inhibitor / 否
HY-161277 HSD17B13-IN-100 Inhibitor / 否
HY-161278 HSD17B13-IN-102 Inhibitor / 否
HY-161979 HSD17B13-IN-103 Inhibitor / 否
HY-162207 HSD17B13-IN-54 Inhibitor / 否
HY-162208 HSD17B13-IN-55 Inhibitor / 否
HY-162209 HSD17B13-IN-63 Inhibitor / 否
HY-162210 HSD17B13-IN-65 Inhibitor / 否
HY-162211 HSD17B13-IN-84 Inhibitor / 否
HY-162212 HSD17B13-IN-85 Inhibitor / 否
HY-162213 HSD17B13-IN-86 Inhibitor / 否
HY-162214 HSD17B13-IN-90 Inhibitor / 否
HY-162215 HSD17B13-IN-88 Inhibitor / 否
HY-162216 HSD17B13-IN-89 Inhibitor / 否
HY-162217 HSD17B13-IN-91 Inhibitor / 否
HY-162219 HSD17B13-IN-93 Inhibitor / 否
HY-162220 HSD17B13-IN-94 Inhibitor / 否
HY-162221 HSD17B13-IN-95 Inhibitor / 否
HY-162222 HSD17B13-IN-96 Inhibitor / 否
HY-162223 HSD17B13-IN-97 Inhibitor / 否
HY-162224 HSD17B13-IN-98 Inhibitor / 否
HY-162225 HSD17B13-IN-99 Inhibitor / 否
HY-162278 HSD17B13-IN-101 Inhibitor / 否
HY-163240 HSD17B13-IN-24 Inhibitor / 否
HY-163241 HSD17B13-IN-25 Inhibitor / 否
HY-163242 HSD17B13-IN-28 Inhibitor / 否
HY-163243 HSD17B13-IN-29 Inhibitor / 否
HY-163244 HSD17B13-IN-30 Inhibitor / 否
HY-163245 HSD17B13-IN-32 Inhibitor / 否
HY-163246 HSD17B13-IN-34 Inhibitor / 否
HY-163247 HSD17B13-IN-35 Inhibitor / 否
HY-163248 HSD17B13-IN-37 Inhibitor / 否
HY-163249 HSD17B13-IN-49 Inhibitor / 否
HY-163250 HSD17B13-IN-51 Inhibitor / 否
HY-163251 HSD17B13-IN-52 Inhibitor / 否
HY-163252 HSD17B13-IN-53 Inhibitor / 否
HY-163253 HSD17B13-IN-56 Inhibitor / 否
HY-163253S HSD17B13-IN-56-d3 Inhibitor / 否
HY-163254 HSD17B13-IN-57 Inhibitor / 否
HY-163255 HSD17B13-IN-58 Inhibitor / 否
HY-163256 HSD17B13-IN-59 Inhibitor / 否
HY-163257 HSD17B13-IN-60 Inhibitor / 否
HY-163258 HSD17B13-IN-61 Inhibitor / 否
HY-163259 HSD17B13-IN-62 Inhibitor / 否
HY-163259S HSD17B13-IN-62-d3 Inhibitor / 否
HY-163260 HSD17B13-IN-64 Inhibitor / 否
HY-163261 HSD17B13-IN-66 Inhibitor / 否
HY-163262 HSD17B13-IN-71 Inhibitor / 否
HY-163263 HSD17B13-IN-80 Inhibitor / 否
HY-163263S HSD17B13-IN-80-d3 Inhibitor / 否
HY-163263S1 HSD17B13-IN-80-d2 Inhibitor / 否
HY-163264 HSD17B13-IN-81 Inhibitor / 否
HY-163265 HSD17B13-IN-82 Inhibitor / 否
HY-163266 HSD17B13-IN-83 Inhibitor / 否
HY-RS06393 HSD17B13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HSD17B13 MGD MGI:2140804
Macaca mulatta HSD17B13 VGNC VGNC:73417
Canis familiaris HSD17B13 VGNC VGNC:41803
Rattus norvegicus HSD17B13 RGD RGD:1359553
Felis catus HSD17B13 VGNC VGNC:62848
Bos taurus HSD17B13 VGNC VGNC:29971
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