2. Gene
  3. SFXN1 - sideroflexin 1 Gene

SFXN1 - sideroflexin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：sideroflexin 1

种属: Homo sapiens

同用名: TCC; SLC56A1

基因 ID: 94081 | 基因类型: protein coding

关于 SFXN1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,478,560-175,529,742 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues and 4 paralogues. Ubiquitous expression in liver (RPKM 20.2), kidney (RPKM 17.3) and 24 other tissues.

功能概要

启用 D-丝氨酸跨膜转运蛋白活性和 L-丝氨酸跨膜转运蛋白活性。参与 D-丝氨酸转运； L-丝氨酸转运；和丝氨酸导入线粒体。位于线粒体中。是线粒体内膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables D-serine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in D-serine transport; L-serine transport; and serine import into mitochondrion. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

SFXN1 基因产物(7)

mRNA Protein Name
NM_001322977.2 NP_001309906.1 sideroflexin-1 isoform 1
NM_001322978.2 NP_001309907.1 sideroflexin-1 isoform 2
NM_001322980.2 NP_001309909.1 sideroflexin-1 isoform 4
NM_001322981.2 NP_001309910.1 sideroflexin-1 isoform 4
NM_001322982.2 NP_001309911.1 sideroflexin-1 isoform 2
NM_001322983.2 NP_001309912.1 sideroflexin-1 isoform 3
NM_022754.7 NP_073591.2 sideroflexin-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-alanine transmembrane transporter activity IDA
IDA: 通过直接分析推断
30442778 GOA
enables L-serine transmembrane transporter activity IDA
IDA: 通过直接分析推断
30442778 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-alanine transport IDA
IDA: 通过直接分析推断
30442778 GOA
involved in L-serine transport IDA
IDA: 通过直接分析推断
30442778 GOA
acts upstream of one-carbon metabolic process IDA
IDA: 通过直接分析推断
30442778 GOA
involved in serine import into mitochondrion IDA
IDA: 通过直接分析推断
30442778 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
27184847 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SFXN1 蛋白结构

Mtc

Mtc: Tricarboxylate carrier (16 - 322)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
蛋白主名 其他名称

sideroflexin-1

tricarboxylate carrier protein

SFXN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SFXN1 Q9H9B4 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra SFXN1 Q9H9B4 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 STOM Homo sapiens P27105
Y2H Array
32296183
Intra SFXN1 Q9H9B4 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra SFXN1 Q9H9B4 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SFXN1 Q9H9B4 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra SFXN1 Q9H9B4 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra SFXN1 Q9H9B4 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 MMD Homo sapiens Q15546
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 MMD Homo sapiens Q15546
Y2H Array
32296183
Intra SFXN1 Q9H9B4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra SFXN1 Q9H9B4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra SFXN1 Q9H9B4 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra SFXN1 Q9H9B4 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra SFXN1 Q9H9B4 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra SFXN1 Q9H9B4 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra SFXN1 Q9H9B4 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra SFXN1 Q9H9B4 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra SFXN1 Q9H9B4 DDI1 Homo sapiens Q8WTU0
Anti Tag CoIP
28514442
Intra SFXN1 Q9H9B4 DDI1 Homo sapiens Q8WTU0
Anti Tag CoIP
33961781
Intra SFXN1 Q9H9B4 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra SFXN1 Q9H9B4 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra SFXN1 Q9H9B4 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra SFXN1 Q9H9B4 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Combined Oxidative Phosphorylation Deficiency 18

Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome

COXPD18

Combined Oxidative Phosphorylation Deficiency, Type 18
Sarcosinemia

Sarcosine Dehydrogenase Complex Deficiency

Sard Deficiency

Sardh Deficiency

SARCOS

Hypersarcosinemia

Sardhd

Demethylation Defect Of N-Methylglycine
Neonatal Anemia

Anemia Neonatal

Anemia, Neonatal

Anaemia Neonatal

Neonatal Anaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12785 SFXN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SFXN1 RGD RGD:1308482
Mus musculus SFXN1 MGD MGI:2137677
Bos taurus SFXN1 VGNC VGNC:34530
Felis catus SFXN1 VGNC VGNC:65069
Canis familiaris SFXN1 VGNC VGNC:46087
Macaca mulatta SFXN1 VGNC VGNC:77244
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