2. Gene
  3. PGRMC2 - progesterone receptor membrane component 2 Gene

PGRMC2 - progesterone receptor membrane component 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：孕酮受体膜成分 2

种属: Homo sapiens

同用名: DG6; PMBP

基因 ID: 10424 | 基因类型: protein coding

关于 PGRMC2

Cytogenetic location: 4q28.2 Genomic coordinates (GRCh38): 4:128,269,242-128,287,813 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.

功能概要

启用血红素结合活动。参与脂肪组织发育。位于内质网和核膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PGRMC2 基因产物(1)

mRNA Protein Name
NM_006320.6 NP_006311.3 membrane-associated progesterone receptor component 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heme binding IDA
IDA: 通过直接分析推断
28111073 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27599036 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adipose tissue development IMP
IMP: 通过突变表型推断
28111073 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
27754849 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
25468996 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PGRMC2 蛋白结构

Cyt-b5

Cyt-b5: Cytochrome b5-like Heme/Steroid binding domain (103 - 200)

  • 0
  • 100
  • 200
  • 223 a.a.
蛋白主名 其他名称

membrane-associated progesterone receptor component 2

progesterone membrane binding protein

PGRMC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PGRMC2 O15173 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
Intra PGRMC2 O15173 SLC39A13 Homo sapiens Q96H72
Validated Y2H
32296183
Intra PGRMC2 O15173 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra PGRMC2 O15173 VAPA Homo sapiens Q9P0L0
Anti Tag CoIP
35271311
Intra PGRMC2 O15173 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra PGRMC2 O15173 FA2H Homo sapiens Q7L5A8
Validated Y2H
32296183
Intra PGRMC2 O15173 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM86A Homo sapiens Q8N2M4
Validated Y2H
32296183
Intra PGRMC2 O15173 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra PGRMC2 O15173 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra PGRMC2 O15173 SLC16A13 Homo sapiens Q7RTY0
Validated Y2H
32296183
Intra PGRMC2 O15173 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
Intra PGRMC2 O15173 SMPD2 Homo sapiens O60906
Validated Y2H
32296183
Intra PGRMC2 O15173 DGAT2L6 Homo sapiens Q6ZPD8
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM107 Homo sapiens Q6UX40
Validated Y2H
32296183
Intra PGRMC2 O15173 TAS2R19 Homo sapiens P59542
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM208 Homo sapiens Q9BTX3
Validated Y2H
32296183
Intra PGRMC2 O15173 ST6GAL2 Homo sapiens Q96JF0-2
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM187 Homo sapiens Q14656
Validated Y2H
32296183
Intra PGRMC2 O15173 STX3 Homo sapiens Q13277
Validated Y2H
32296183
Intra PGRMC2 O15173 CYP4F2 Homo sapiens P78329
Validated Y2H
32296183
Intra PGRMC2 O15173 GET3 Homo sapiens O43681
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra PGRMC2 O15173 ITPRIP Homo sapiens Q8IWB1
Anti Tag CoIP
35271311
Intra PGRMC2 O15173 ITPRIP Homo sapiens Q8IWB1
Validated Y2H
32296183
Intra PGRMC2 O15173 ITGAM Homo sapiens P11215
Validated Y2H
32296183
Intra PGRMC2 O15173 COX20 Homo sapiens Q5RI15
Validated Y2H
32296183
Intra PGRMC2 O15173 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
Intra PGRMC2 O15173 ZDHHC21 Homo sapiens Q8IVQ6
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra PGRMC2 O15173 MFHAS1 Homo sapiens Q9Y4C4
Protein Array
29513927
Intra PGRMC2 O15173 GHITM Homo sapiens Q9H3K2
Validated Y2H
32296183
Intra PGRMC2 O15173 TECR Homo sapiens Q9NZ01
Validated Y2H
32296183
Intra PGRMC2 O15173 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra PGRMC2 O15173 BAG4 Homo sapiens O95429
Validated Y2H
32296183
Intra PGRMC2 O15173 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra PGRMC2 O15173 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
Intra PGRMC2 O15173 RNF8 Homo sapiens O76064
Validated Y2H
32296183
Intra PGRMC2 O15173 TSPAN2 Homo sapiens O60636
Validated Y2H
32296183
Intra PGRMC2 O15173 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Intra PGRMC2 O15173 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra PGRMC2 O15173 MFSD5 Homo sapiens Q6N075
Y2H Array
32296183
Intra PGRMC2 O15173 DHRSX Homo sapiens Q8N5I4
Validated Y2H
32296183
Intra PGRMC2 O15173 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra PGRMC2 O15173 TF Homo sapiens P02787
Validated Y2H
32296183
Cross PGRMC2 O15173 Fech Mus musculus P22315
Anti Tag CoIP
27599036
Intra PGRMC2 O15173 ZFPL1 Homo sapiens O95159
Validated Y2H
32296183
Intra PGRMC2 O15173 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra PGRMC2 O15173 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra PGRMC2 O15173 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra PGRMC2 O15173 C5 Homo sapiens P01031
Validated Y2H
32296183
Intra PGRMC2 O15173 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra PGRMC2 O15173 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra PGRMC2 O15173 SLC9B2 Homo sapiens Q86UD5
Validated Y2H
32296183
Intra PGRMC2 O15173 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome

Triple-A Syndrome

Achalasia-Addisonianism-Alacrimia Syndrome

Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder

Triple A Syndrome

Aaa Syndrome

AAAS

Glucocorticoid Deficiency With Achalasia

Glucocorticoid Deficiency And Achalasia

Addisonian-Achalasia Syndrome

Hypoadrenalism With Achalasia

Alacrima-Achalasia-Addisonianism

Aaa

Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima

Achalasia Addisonianism Alacrimia Syndrome

Achalasia Alacrima Syndrome

Addisonian Achalasia Syndrome

Achalasia-Addisonian Syndrome

Achalasia-Alacrima Syndrome

2a Syndrome

3a Syndrome

4a Syndrome

Adrenal Insufficiency-Achalasia-Alacrima Syndrome

Double A Syndrome

Quaternary A Syndrome

Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima

Allgrove'S Syndrome

Adrenal Gland Hypofunction

Adrenal Cortical Hypofunction
Clivus Chordoma

Chordoma Of Clivus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10400 PGRMC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PGRMC2 RGD RGD:1308804
Bos taurus PGRMC2 VGNC VGNC:32802
Canis familiaris PGRMC2 VGNC VGNC:44471
Mus musculus PGRMC2 MGD MGI:1918054
Felis catus PGRMC2 VGNC VGNC:64126
Macaca mulatta PGRMC2 VGNC VGNC:107190
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