1. Gene
  2. SLC9B2 - solute carrier family 9 member B2 Gene

SLC9B2 - solute carrier family 9 member B2 Gene

中文名称:溶质载体家族 9 成员 B2

种属: Homo sapiens

同用名: NHA2; NHE10; NHEDC2

基因 ID: 133308 | 基因类型: protein coding

关于 SLC9B2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:103,018,029-103,077,319 (from NCBI)

This gene has 11 transcripts (splice variants), 293 orthologues and 1 paralogue. Broad expression in brain (RPKM 4.9), liver (RPKM 4.7) and 21 other tissues.

功能概要

钠氢反向转运蛋白,如 NHEDC2,将呼吸链或 F1F0 线粒体 ATP 酶建立的质子动力转化为钠梯度,驱动其他需要能量的过程,将环境信号转导为细胞反应,或在药物外排中发挥作用 (Xiang 等人., 2007 [PubMed 18000046]) .[OMIM 提供,2008 年 3 月]

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive Other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

SLC9B2 基因产物(12)

mRNA Protein Name
NM_001300754.2 NP_001287683.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001300756.2 NP_001287685.1 sodium/hydrogen exchanger 9B2 isoform 3
NM_001370199.1 NP_001357128.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_001370200.1 NP_001357129.1 sodium/hydrogen exchanger 9B2 isoform 5
NM_001370201.1 NP_001357130.1 sodium/hydrogen exchanger 9B2 isoform 1
NM_001370202.1 NP_001357131.1 sodium/hydrogen exchanger 9B2 isoform 1
NM_001370203.1 NP_001357132.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001370204.1 NP_001357133.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001370205.1 NP_001357134.1 sodium/hydrogen exchanger 9B2 isoform 3
NM_001370206.1 NP_001357135.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_001370207.1 NP_001357136.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_178833.7 NP_849155.2 sodium/hydrogen exchanger 9B2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
28071645 GOA
enables lithium:proton antiporter activity IDA
IDA: 通过直接分析推断
36177733 GOA
enables lithium:proton antiporter activity IMP
IMP: 通过突变表型推断
18000046 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sodium:proton antiporter activity EXP
EXP: 通过实验结果推断
28154142 GOA
enables sodium:proton antiporter activity IDA
IDA: 通过直接分析推断
36177733 GOA
enables sodium:proton antiporter activity IMP
IMP: 通过突变表型推断
18000046 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lithium ion transport IDA
IDA: 通过直接分析推断
36177733 GOA
involved in sodium ion transport IDA
IDA: 通过直接分析推断
18508966 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
18508966 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18000046 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC9B2 蛋白结构

Na_H_Exchanger

Na_H_Exchanger: Sodium/hydrogen exchanger family (129 - 508)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
蛋白主名 其他名称

sodium/hydrogen exchanger 9B2

NHE domain-containing protein 2

SLC9B2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC9B2 Q86UD5 PGRMC2 Homo sapiens O15173 32296183
种属内
SLC9B2 Q86UD5 PGRMC2 Homo sapiens O15173 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC9B2 RGD RGD:1598112
Macaca mulatta SLC9B2 VGNC VGNC:77773
Felis catus SLC9B2 VGNC VGNC:65440
Canis familiaris SLC9B2 VGNC VGNC:54362
Bos taurus SLC9B2 VGNC VGNC:34948
Mus musculus SLC9B2 MGD MGI:2140077