1. Gene
  2. SLC9B2 - solute carrier family 9 member B2 Gene

SLC9B2 - solute carrier family 9 member B2 Gene

中文名称:溶质载体家族 9 成员 B2

种属: Homo sapiens

同用名: NHA2; NHE10; NHEDC2

基因 ID: 133308 | 基因类型: protein coding

关于 SLC9B2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:103,018,029-103,077,319 (from NCBI)

This gene has 11 transcripts (splice variants), 293 orthologues and 1 paralogue. Broad expression in brain (RPKM 4.9), liver (RPKM 4.7) and 21 other tissues.

功能概要

钠氢反向转运蛋白,如 NHEDC2,将呼吸链或 F1F0 线粒体 ATP 酶建立的质子动力转化为钠梯度,驱动其他需要能量的过程,将环境信号转导为细胞反应,或在药物外排中发挥作用 (Xiang 等人., 2007 [PubMed 18000046]) .[OMIM 提供,2008 年 3 月]

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

SLC9B2 基因产物(12)

mRNA Protein Name
NM_001300754.2 NP_001287683.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001300756.2 NP_001287685.1 sodium/hydrogen exchanger 9B2 isoform 3
NM_001370199.1 NP_001357128.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_001370200.1 NP_001357129.1 sodium/hydrogen exchanger 9B2 isoform 5
NM_001370201.1 NP_001357130.1 sodium/hydrogen exchanger 9B2 isoform 1
NM_001370202.1 NP_001357131.1 sodium/hydrogen exchanger 9B2 isoform 1
NM_001370203.1 NP_001357132.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001370204.1 NP_001357133.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001370205.1 NP_001357134.1 sodium/hydrogen exchanger 9B2 isoform 3
NM_001370206.1 NP_001357135.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_001370207.1 NP_001357136.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_178833.7 NP_849155.2 sodium/hydrogen exchanger 9B2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
28071645 GOA
enables lithium:proton antiporter activity IDA
IDA: 通过直接分析推断
36177733 GOA
enables lithium:proton antiporter activity IMP
IMP: 通过突变表型推断
18000046 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sodium:proton antiporter activity EXP
EXP: 通过实验结果推断
28154142 GOA
enables sodium:proton antiporter activity IDA
IDA: 通过直接分析推断
36177733 GOA
enables sodium:proton antiporter activity IMP
IMP: 通过突变表型推断
18000046 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lithium ion transport IDA
IDA: 通过直接分析推断
36177733 GOA
involved in sodium ion transport IDA
IDA: 通过直接分析推断
18508966 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
18508966 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18000046 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC9B2 蛋白结构

Na_H_Exchanger

Na_H_Exchanger: Sodium/hydrogen exchanger family (129 - 508)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
蛋白主名 其他名称

sodium/hydrogen exchanger 9B2

NHE domain-containing protein 2

SLC9B2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC9B2 Q86UD5 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra SLC9B2 Q86UD5 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC9B2 RGD RGD:1598112
Macaca mulatta SLC9B2 VGNC VGNC:77773
Felis catus SLC9B2 VGNC VGNC:65440
Canis familiaris SLC9B2 VGNC VGNC:54362
Bos taurus SLC9B2 VGNC VGNC:34948
Mus musculus SLC9B2 MGD MGI:2140077