SLC38A1 - solute carrier family 38 member 1 Gene

中文名称：溶质载体家族 38 成员 1

种属: Homo sapiens

同用名: ATA1; NAT2; SAT1; SNAT1

基因 ID: 81539 | 基因类型: protein coding

关于 SLC38A1

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:46,183,063-46,269,043 (from NCBI)

This gene has 11 transcripts (splice variants), 161 orthologues and 15 paralogues. Broad expression in lymph node (RPKM 24.7), thyroid (RPKM 21.1) and 23 other tissues.

功能概要

氨基酸转运蛋白在营养物质的摄取、能量的产生、化学代谢、解毒和神经递质循环中发挥重要作用。 SLC38A1 是谷氨酰胺的重要转运蛋白，谷氨酰胺是氨解毒和尿素生产的中间体。谷氨酰胺作为突触递质谷氨酸的前体 (Gu et al., 2001 [PubMed 11325958]) 。[OMIM 提供，2008 年 3 月]

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]

SLC38A1 基因产物(6)

mRNA	Protein	Name
NM_001077484.2	NP_001070952.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278387.2	NP_001265316.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278388.2	NP_001265317.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278389.2	NP_001265318.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278390.1	NP_001265319.1	sodium-coupled neutral amino acid symporter 1 isoform 2
NM_030674.4	NP_109599.3	sodium-coupled neutral amino acid symporter 1 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	23137377	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC38A1 蛋白结构

Aa_trans

0
100
200
300
400
487 a.a.

蛋白主名

其他名称

sodium-coupled neutral amino acid symporter 1

sodium-coupled neutral amino acid transporter 1

N-system amino acid transporter 2

SLC38A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLC38A1	Q9H2H9	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	SLC38A1	Q9H2H9	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	SLC13A4	Homo sapiens	Q9UKG4	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	SLC13A4	Homo sapiens	Q9UKG4	Validated Y2H	32296183
Intra	SLC38A1	Q9H2H9	SLC13A4	Homo sapiens	Q9UKG4	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	SLC38A1	Q9H2H9	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	SLC38A1	Q9H2H9	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	SLC38A1	Q9H2H9	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	SLC38A1	Q9H2H9	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	SLC38A1	Q9H2H9	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC38A1	Q9H2H9	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Klatskin'S Tumor

Klatskin Tumor	Hilar Cholangiocarcinoma
Perihilar Cholangiocarcinoma	Hilar Cholangiocellular Carcinoma
Klatskin Tumour	Klatskin'S Tumour
Perihilar Extrahepatic Bile Duct Carcinoma	Hilar Cca
Adenocarcinoma Of Hepatic Duct	Klatskin Tumour Of Biliary Tree

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13217	SLC38A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SLC38A1	VGNC	VGNC:77468
Mus musculus	SLC38A1	MGD	MGI:2145895
Canis familiaris	SLC38A1	VGNC	VGNC:46390
Bos taurus	SLC38A1	VGNC	VGNC:34846
Rattus norvegicus	SLC38A1	RGD	RGD:69645
Felis catus	SLC38A1	VGNC	VGNC:65342
Others	SLC38A1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC38A1 - solute carrier family 38 member 1 Gene

关于 SLC38A1

功能概要

SLC38A1 基因产物(6)

SLC38A1 蛋白结构

SLC38A1 蛋白互作信息

关联疾病

直系同源

热门区域

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SLC38A1 - solute carrier family 38 member 1 Gene

关于 SLC38A1

功能概要

SLC38A1 基因产物(6)

SLC38A1 蛋白结构

SLC38A1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z