SLC13A4 - solute carrier family 13 member 4 Gene

中文名称：溶质载体家族 13 成员 4

种属: Homo sapiens

同用名: NAS2; SUT1; SUT-1

基因 ID: 26266 | 基因类型: protein coding

关于 SLC13A4

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,681,231-135,728,186 (from NCBI)

This gene has 8 transcripts (splice variants), 214 orthologues and 5 paralogues. Biased expression in placenta (RPKM 28.4) and testis (RPKM 3.0).

功能概要

预计会启用钠：硫酸盐同向转运体活性。预计参与阴离子跨膜转运。预测位于质膜中。预计是质膜的组成部分。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable sodium:sulfate symporter activity. Predicted to be involved in anion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC13A4 基因产物(2)

mRNA	Protein	Name
NM_001318192.2	NP_001305121.1	solute carrier family 13 member 4 isoform 1
NM_012450.4	NP_036582.2	solute carrier family 13 member 4 isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables sodium:sulfate symporter activity	IDA IDA: 通过直接分析推断	10535998	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC13A4 蛋白结构

Na_sulph_symp

0
100
200
300
400
500
626 a.a.

蛋白主名

其他名称

solute carrier family 13 member 4

Na(+)/sulfate cotransporter SUT-1

SLC13A4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLC13A4	Q9UKG4	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	SLC13A4	Q9UKG4	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	SLC13A4	Q9UKG4	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	SLC13A4	Q9UKG4	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	SLC13A4	Q9UKG4	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC13A4	Q9UKG4	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Chondrodysplasia With Joint Dislocations, Gpapp Type

Gpapp Deficiency	Chondrodysplasia With Joint Dislocations Gpapp Type
CDP-GPAPP	Chondrodysplasia, With Joint Dislocations, Gpapp Type

Developmental And Epileptic Encephalopathy 25

Developmental And Epileptic Encephalopathy, 25	Dee25
Developmental And Epileptic Encephalopathy 25, With Amelogenesis Imperfecta	Early Infantile Epileptic Encephalopathy 25
Encephalopathy, Epileptic, Early Infantile, Type 25

Myopathy, Myosin Storage, Autosomal Dominant

MSMA	Myopathy, Hyaline Body, Autosomal Dominant
Myopathy With Lysis Of Type I Myofibrils	Autosomal Dominant Hyaline Body Myopathy
Hyaline Body Myopathy Autosomal Dominant

Achondrogenesis, Type Ib

ACG1B	Achondrogenesis Type Ib
Achondrogenesis Type 1b	Achondrogenesis Ib
Achondrogenesis Fraccaro Type	Achondrogenesis, Fraccaro Type
Achondrogenesis, Parenti-Fraccaro Type	Achondrogenesis 1b
Acg-Ib	Fraccaro Achondrogenesis

Schizophrenia 2

SCZD2	Schizophrenia Susceptibility Locus, Chromosome 11q-Related
Schizophrenia Susceptibility Locus Chromosome 11q-Related

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13008	SLC13A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC13A4	MGD	MGI:2442367
Macaca mulatta	SLC13A4	VGNC	VGNC:77489
Felis catus	SLC13A4	VGNC	VGNC:102703
Canis familiaris	SLC13A4	VGNC	VGNC:46230
Bos taurus	SLC13A4	VGNC	VGNC:34676
Rattus norvegicus	SLC13A4	RGD	RGD:1359715

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